Effects of acetaminophen rectal: A Synthesis of Findings from 13 Studies

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Original Abstract of the Article

Main Research Findings

Acetaminophen rectal can be effective in reducing post-operative pain in children. Studies have shown that acetaminophen rectal can reduce pain scores compared to placebo or other analgesics. 7 , 4 , 10 , 9 , 2 Some studies suggest that acetaminophen rectal can even further reduce pain when used in combination with ropivacaine or other analgesics. 8 , 11 However, acetaminophen rectal may not always be effective. 1 Some studies have shown that acetaminophen rectal can be less effective than other analgesics in reducing pain. 5 Additionally, acetaminophen rectal has been shown to have a longer duration of analgesic effect compared to oral or intravenous administration. 10 , 2

Benefits and Risks

Benefit Summary

Acetaminophen rectal can be a helpful tool for reducing post-operative pain in children. Acetaminophen rectal has been shown to reduce pain scores compared to placebo or other analgesics. Additionally, acetaminophen rectal has been shown to have a longer duration of analgesic effect compared to oral or intravenous administration. Furthermore, acetaminophen rectal may even further reduce pain when used in combination with ropivacaine or other analgesics.

Risk Summary

While acetaminophen rectal can be helpful for reducing post-operative pain in children, it is not without risk. Some studies have shown that acetaminophen rectal can be less effective than other analgesics in reducing pain. Acetaminophen rectal may also exacerbate the pain response in newborns. 1 When using acetaminophen rectal, it is important to use the appropriate dosage for the child and follow the instructions of your doctor.

Comparison Across Studies

Commonalities Among Studies

These studies all used acetaminophen rectal to reduce post-operative pain in children. They all showed that acetaminophen rectal may have potential to reduce pain scores.

Differences Among Studies

These studies varied in many ways, such as the children involved, the types of surgeries, the dosage of acetaminophen rectal used, and the methods used to assess pain scores. Some studies suggested that acetaminophen rectal was more effective than other analgesics, while others showed no difference.

Consistency and Contradictions in Findings

The findings of these studies are not entirely consistent. While some studies suggest that acetaminophen rectal is effective, others suggest that it is not. The contradictions in these findings may be due to many factors, such as the children involved, the types of surgeries, the dosage of acetaminophen rectal used, and the methods used to assess pain scores.

Practical Applications and Caveats

Acetaminophen rectal can be a valuable tool for reducing post-operative pain in children, but the findings of these studies are not entirely consistent. When using acetaminophen rectal, it is important to consider the child's individual situation, age, type of surgery, and the doctor's instructions.

Limitations of the Current Research

These studies have several limitations. For example, some studies had small sample sizes or short follow-up periods. Additionally, the long-term effects of acetaminophen rectal were not fully investigated in these studies. These limitations should be considered when interpreting the findings of these studies.

Future Research Directions

Further research is needed to explore the long-term effects and safety of acetaminophen rectal, the optimal dosage, and the most effective methods of administration. These studies could help to develop more effective treatments for post-operative pain in children.

Conclusion

These studies suggest that acetaminophen rectal may be a helpful tool for reducing post-operative pain in children. However, the findings of these studies are not entirely consistent. When using acetaminophen rectal, it is important to consider the child's individual situation, age, type of surgery, and the doctor's instructions. Further research is needed to explore the long-term effects and safety of acetaminophen rectal, the optimal dosage, and the most effective methods of administration.

Literature analysis of 13 papers
Positive Content
11
Neutral Content
0
Negative Content
2
Article Type
6
0
0
1
13
1.

Rectal paracetamol in newborn infants after assisted vaginal delivery may increase pain response.

Author: TinnerEva Maria, HoesliIrene, JostKerstin, SchöbiNina, Ulrich MeggedYvonne, BurkhardtTilo, KrafftAlexander, BucherHans Ulrich, SurbekDaniel, NelleMathias, BührerChristoph

Stress response aggravation

Paracetamol given to newborns soon after birth may not alleviate pain but may actually aggravate a subsequent stress response, as indicated by higher pain scores after a heel prick at days 2-3 of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Effects of milk replacer feeding rate and frequency of preweaning dairy calves in the southeastern United States: Performance, abomasal emptying, and nutrient digestibility.

Author: Orellana RivasRuth M, RodriguesThalyane, da Silveira E SousaJordana, MeloVictor H L R, GaoJing, Ferreira de AraújoDiego, Goncalves de SouzaJuliana, MarinsThiago N, MelendezPedro, BernardJohn K, TaoSha

Abomasal emptying
Calf growth
Heat stress

This study examines the effects of milk replacer (MR) feeding rate and frequency on the performance, abomasal emptying, and nutrient digestibility of dairy calves. Feeding more frequently accelerated abomasal emptying and reduced heat load in calves, particularly during summer. Increasing the MR allowance improved growth in both seasons but delayed abomasal emptying under heat stress conditions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled Trial, VeterinaryRandomized controlled trials involving animals. They evaluate the efficacy and safety of treatment methods.

Language : English

5.

Pharmacokinetic comparison of acetaminophen elixir versus suppositories in vaccinated infants (aged 3 to 36 months): a single-dose, open-label, randomized, parallel-group design.

Author: WalsonPhilip D, HalvorsenMark, EdgeJames, CasavantMarcel J, KelleyMichael T

Rapid peak concentrations
Similar absorption

The rectal suppository and elixir preparations of acetaminophen (ACET) produced similar, rapid peak concentrations and elimination t(½). No statistically significant differences were found between either C(max) or total drug exposure.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

6.

Febrile Seizures: Risks, Evaluation, and Prognosis.

Author: SmithDustin K, SadlerKerry P, BenedumMolly

Febrile seizures

Febrile seizures are common in children aged 6 months to 5 years, and are usually caused by a fever. Most febrile seizures are simple and don't require any tests. However, complex seizures can last for more than 15 minutes and might indicate a more serious condition. While children with febrile seizures are more likely to have them again, they generally don't have any long-term negative effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Effect of rectal diclofenac and acetaminophen alone and in combination on postoperative pain after cleft palate repair in children.

Author: MireskandariSeyed Mohammad, MakaremJalil

effective pain relief
pain control

A combination of acetaminophen and diclofenac was found to be the most effective in pain control after cleft palate surgery in children.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Assessment of the Analgesic Effects of Extrapleural Infusion of Ropivacaine in Neonates with Esophageal Atresia (EA) Repair.

Author: RouzrokhMohsen, MirkheshtiAlireza, MirshemiraniAlireza, SadeghiAfsaneh, TavassoliAzita, Khaleghnejad TabariAhmad

Atelectasis reduction
Pain relief

Continuous extrapleural infusion of ropivacaine significantly reduced pain and atelectasis in neonates younger than 7 days old with esophageal atresia compared to acetaminophen treatment after thoracotomy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

COMPARISON OF THE EFFECTS OF PREEMPTIVE INTRAVENOUS AND RECTAL ACETAMINOPHEN ON PAIN MANAGEMENT AFTER INGUINAL HERNIORRHAPHY IN CHILDREN: A PLACEBO-CONTROLLED STUDY.

Author: KhaliliGholam Reza, ShafaAmir, YousefiRamin

Pain management

This study compared the analgesic efficacy of intravenous (IV) and rectal acetaminophen versus placebo in children undergoing inguinal herniorrhaphy. The study found that both IV and rectal acetaminophen were more effective than placebo in relieving postoperative pain.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Comparing the duration of the analgesic effects of intravenous and rectal acetaminophen following tonsillectomy in children.

Author: HaddadiSoudabeh, MarzbanShideh, KaramiMohammad Seddigh, HeidarzadehAbtin, ParviziArman, Naderi NabiBahram

Delayed need for additional analgesics
Reduced pain

Rectal acetaminophen is more effective at controlling post-adenotonsillectomy pain in children than intravenous acetaminophen.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Rectal acetaminophen versus peritonsillar infiltration of bupivacaine for postoperative analgesia after adenotonsillectomy in children.

Author: Dahi-TaleghaniMastaneh, MousavifardSamira, TahmoureszadeShahrokh, DabbaghAli

Pain relief

This randomized controlled trial compared the postoperative analgesic effects of peritonsillar bupivacaine infiltration and rectal acetaminophen suppositories in children undergoing adenotonsillectomy. Rectal acetaminophen showed similar pain relief with fewer risks compared to bupivacaine infiltration.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings.

Author: HonasogeAkilesh, LyonsNeal, HesseKathleen, ParkerBraden, MokszyckiRobert, WesselhoffKelly, SweisRolla, KulstadErik B

Medication delivery

This article discusses a novel rectal device for medication and fluid administration. It describes the device's placement and use, including examples of successful treatment for various conditions. Additionally, it highlights the device's potential for rapid medication absorption.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Video-Audio MediaMedia that combines video and audio. Includes movies, TV shows, and online videos.

Language : English

13.

Randomized Population Pharmacokinetic Analysis and Safety of Intravenous Acetaminophen for Acute Postoperative Pain in Neonates and Infants.

Author: HammerGregory B, MaxwellLynne G, TaicherBrad M, VisoiuMihaela, CooperDavid S, SzmukPeter, PhengLeng Hong, GosselinNathalie H, LuJia, DevarakondaKrishna

Postoperative pain treatment

Intravenous acetaminophen was safe and effective for the treatment of acute postoperative pain in neonate and infant patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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