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Effects of D-timolol and L-timolol eye drops on intraocular pressure and aqueous flow. A dose-response study in normal eyes.

Author: AlmA, KoskelaT, TaarnhøjJ

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

L-timolol was more effective than D-timolol in reducing intraocular pressure in healthy volunteers, with a dose-response relationship observed for D-timolol.
Paper Details　
Original Abstract of the Article :
The effect on intraocular pressure of 0.5, 1.0, 2.0 or 4.0% D-timolol and 0.25 or 0.5% L-timolol was determined in healthy volunteers after a single topical application. A dose-response relationship for D-timolol could be established. The effect on a diurnal pressure curve and on aqueous humour prod...See full text at original site
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引用元：
https://doi.org/10.1111/j.1755-3768.1990.tb01643.x

データ提供：米国国立医学図書館（NLM）

D-Timolol and L-Timolol: A Comparative Study in the Desert of Glaucoma

Glaucoma, a silent thief of vision, continues to pose a significant challenge in ophthalmology. This research explores the comparative effects of D-timolol and L-timolol, two beta-blockers commonly used to lower intraocular pressure, on intraocular pressure and aqueous flow in normal eyes. The study revealed a distinct dose-response relationship for D-timolol and a significantly stronger effect for L-timolol, even at lower doses. This finding, like a desert mirage, offers a new perspective on the efficacy and potential benefits of these medications in managing glaucoma.

Navigating the Desert of Glaucoma Treatment: A Doctor's Perspective

This research underscores the importance of carefully considering the specific needs of each patient when choosing a treatment for glaucoma. Like a skilled desert navigator, a doctor must carefully assess the patient's individual risk factors, medical history, and potential side effects before recommending any treatment strategy. This personalized approach, coupled with ongoing research and development of new therapies, can help patients navigate the complexities of glaucoma, ultimately preserving their vision and ensuring a clear path through the desert of this challenging disease.

Seeing Clearly in the Desert: A Doctor's Perspective

This research sheds light on the nuances of glaucoma treatment, reminding us that even subtle differences in medications can have a significant impact on patient outcomes. Like a skilled desert guide, a doctor must be aware of these nuances and make informed decisions to provide the best possible care for their patients, ensuring that they maintain clear vision and continue to enjoy the beauty of the world around them.

Dr. Camel's Conclusion

This comparative study provides valuable insights into the effects of D-timolol and L-timolol on intraocular pressure and aqueous flow, highlighting the importance of careful dose selection and personalized treatment approaches for glaucoma management.
Date :
  1. Date Completed 1990-06-14
  2. Date Revised 2019-08-20
Further Info :

Pubmed ID

2336928

DOI: Digital Object Identifier

10.1111/j.1755-3768.1990.tb01643.x

Related Literature

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・Effects of timolol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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