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Population pharmacokinetics of tranexamic acid in paediatric patients undergoing craniosynostosis surgery.

Author: GoobieSusan M, MeierPetra M, PereiraLuis M, SamantSnehal, SethnaNavil F, SorianoSulpicio G, ZurakowskiDavid

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Tranexamic acid (TXA) effectively reduces blood loss during craniofacial surgery in children. This study aims to characterize the pharmacokinetics of TXA in pediatric patients to guide dosing practices.
Paper Details　
Original Abstract of the Article :
Tranexamic acid (TXA) effectively reduces blood loss and transfusion requirements during craniofacial surgery. The pharmacokinetics of TXA have not been fully characterized in paediatric patients and dosing regimens remain diverse in practice. A mixed-effects population analysis would characterize p...See full text at original site
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引用元：
https://doi.org/10.1007/s40262-013-0033-1

データ提供：米国国立医学図書館（NLM）

Tranexamic Acid in Pediatric Craniosynostosis Surgery

This research examines the pharmacokinetics of tranexamic acid (TXA) in pediatric patients undergoing craniosynostosis surgery. Imagine TXA as a trusty camel, helping to reduce blood loss during this delicate procedure. The study aims to characterize the absorption, distribution, metabolism, and excretion of TXA in children, providing valuable insights for optimizing its dosage and administration. This information is crucial for ensuring the safe and effective use of TXA in this specific population.

Optimizing TXA Dosage for Pediatric Patients

The research findings will help to refine the dosing regimen for TXA in pediatric patients undergoing craniosynostosis surgery. This is like finding the perfect oasis in the desert, ensuring the right amount of water for a safe and successful journey. By understanding the pharmacokinetic profile of TXA in children, healthcare professionals can tailor the dosage to individual patient needs, optimizing the medication's effectiveness while minimizing the risk of adverse effects.

Improving Safety and Efficacy in Pediatric Surgery

This research contributes to improving the safety and efficacy of TXA in pediatric craniosynostosis surgery. This is like creating a safer and more efficient path through the desert, ensuring a smoother and more successful surgical experience for young patients. By optimizing the dosage and administration of TXA, we can minimize blood loss, reduce the need for transfusions, and enhance the overall outcome of surgery.

Dr.Camel's Conclusion

This research, like a carefully planned caravan journey, aims to optimize the use of TXA in pediatric craniosynostosis surgery. By understanding the pharmacokinetic profile of TXA in children, we can ensure safe and effective administration, promoting optimal surgical outcomes for young patients. It's a journey towards a healthier future for children, guided by scientific insights and compassionate care.

Date :
  1. Date Completed 2013-09-03
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23371895

DOI: Digital Object Identifier

10.1007/s40262-013-0033-1

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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