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Ocular pharmacokinetics, safety and efficacy of intracameral moxifloxacin 0.5% solution in a rabbit model.

Author: AkovaYonca A, AsenaLeyla, BozkurtAtilla, DemiralayEbru, GoktaşMustafa T, KarabayGülten, YaşarUmit

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Intracameral moxifloxacin injection for endophthalmitis prophylaxis is a safe and effective method in uncomplicated phacoemulsification surgery.
Paper Details　
Original Abstract of the Article :
PURPOSE: This study was carried out to determine the ocular pharmacokinetics, efficacy and potential endothelial toxicity of moxifloxacin (MF) after a single intracameral bolus injection of 500 µg/0.1 ml in a rabbit model. MATERIALS AND METHODS: Forty-eight eyes of 24 New Zealand White Rabbits were...See full text at original site
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引用元：
https://doi.org/10.3109/02713683.2012.763101

データ提供：米国国立医学図書館（NLM）

Intracameral Moxifloxacin: A Powerful Protector Against Endophthalmitis

The field of [ophthalmology] is always seeking ways to prevent [endophthalmitis], a serious eye infection. This study investigated the efficacy of [intracameral moxifloxacin] for endophthalmitis prophylaxis. Researchers injected [a single intracameral bolus of 0.5% moxifloxacin] into the eyes of rabbits. They found that [moxifloxacin reached therapeutic levels in the aqueous humor and vitreous humor] and was effective against a range of endophthalmitis pathogens. The study also demonstrated [the safety of intracameral moxifloxacin] for the cornea.

A Powerful Shield Against Endophthalmitis

This research suggests that [intracameral moxifloxacin] could be a valuable tool for preventing endophthalmitis. The study's findings demonstrate [the effectiveness of moxifloxacin in achieving therapeutic concentrations] and protecting against infection.

Safeguarding Eye Health

Protecting the eyes from infection is as important as protecting a camel's eyes from the glare of the desert sun. This study provides a new shield against endophthalmitis, suggesting that [intracameral moxifloxacin] could help preserve eye health.

Dr. Camel's Conclusion

This study sheds light on the potential of intracameral moxifloxacin as a powerful protector against endophthalmitis. The researchers have revealed a new way to safeguard eye health, offering a glimmer of hope for patients undergoing eye surgery.

Date :
  1. Date Completed 2013-09-03
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

23373761

DOI: Digital Object Identifier

10.3109/02713683.2012.763101

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Article Analysis
・Effects of moxifloxacin injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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