Effects of moxifloxacin injection: A Synthesis of Findings from 12 Studies

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Original Abstract of the Article

Main Research Findings

Moxifloxacin has been shown to be effective in the treatment of experimental Bacillus cereus endophthalmitis in several studies. 12 found that the group treated with moxifloxacin intravitreally had significantly lower vitreous inflammation clinical and histological scores compared to the control group. 11 found that moxifloxacin reaches high concentrations in the eye following intracameral injection, exceeding the minimum inhibitory concentration (MIC) of common endophthalmitis pathogens. found that patients who received intracameral moxifloxacin injection after cataract surgery had a significantly lower incidence of endophthalmitis compared to those who did not. 10 reported a 3-fold decrease in the risk of endophthalmitis in patients who received intracameral moxifloxacin. 5 also showed a significant reduction in the incidence of endophthalmitis in patients who received intracameral moxifloxacin after cataract surgery. These studies provide evidence that moxifloxacin is effective in treating experimental Bacillus cereus endophthalmitis and suggests a possible prophylactic effect against endophthalmitis after cataract surgery.

Benefits and Risks

Benefit Summary

Intracameral moxifloxacin injection has been shown to be effective in the treatment of experimental Bacillus cereus endophthalmitis and may be beneficial in preventing endophthalmitis after cataract surgery. Additionally, moxifloxacin reaches high concentrations in the eye after intracameral injection, which exceeds the MIC of many endophthalmitis-causing pathogens. 12 11 10 5

Risk Summary

The risk of intracameral moxifloxacin injection includes the possibility of increased iris permeability, as documented in 6 . However, no serious side effects of moxifloxacin intracameral injection were reported in these studies.

Comparison between Studies

Commonalities in Studies

These studies all suggest that moxifloxacin intracameral injection is effective in treating or preventing Bacillus cereus endophthalmitis. 12 11 10 5

Differences in Studies

These studies differ in the concentration of moxifloxacin used, the method of injection, and the targeted condition. 12 11 10 5

Consistency and Contradictions of Results

The studies reviewed here provide a consistent indication that intracameral moxifloxacin injection is effective in treating or preventing Bacillus cereus endophthalmitis. However, there are no studies comparing moxifloxacin to other treatment options.

Practical Application and Cautions

While these studies suggest that moxifloxacin intracameral injection could be effective in treating Bacillus cereus endophthalmitis or preventing endophthalmitis after cataract surgery, it is important to note that all of these studies were either animal experiments or small clinical trials. 12 11 10 5 Further research is required to confirm these findings and determine the optimal dose and route of administration before moxifloxacin intracameral injection can be used clinically. Additionally, while moxifloxacin intracameral injection may be effective in preventing or treating infections, the risk of side effects should be carefully considered.

Limitations of Current Research

All of these studies were small-scale, and larger clinical trials are needed to confirm the findings. Moreover, there are no studies comparing moxifloxacin intracameral injection to other treatment options.

Future Research Directions

Larger clinical trials are needed to evaluate the safety and efficacy of moxifloxacin intracameral injection. Additional research is also needed to compare moxifloxacin intracameral injection to other treatment options.

Conclusion

Moxifloxacin has been shown to be effective in the treatment of experimental Bacillus cereus endophthalmitis and may be effective in preventing endophthalmitis after cataract surgery. 12 11 10 5 However, further research is needed to confirm the findings of these studies, which were all either animal experiments or small clinical trials, before moxifloxacin intracameral injection can be used clinically.

Literature analysis of 12 papers
Positive Content
9
Neutral Content
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Negative Content
3
Article Type
4
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12
1.

The influence of age and gender on the pharmacokinetics of moxifloxacin.

Author: SullivanJ T, LettieriJ T, LiuP, HellerA H

Antibacterial effects
Reduced bioavailability

Moxifloxacin does not exhibit age- or gender-dependent pharmacokinetics. Oral doses of 200 to 400mg yield effective antibacterial concentrations on the first day of administration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Effects of sucralfate on the oral bioavailability of moxifloxacin, a novel 8-methoxyfluoroquinolone, in healthy volunteers.

Author: StassH, SchühlyU, MöllerJ G, DelesenH

Reduced bioavailability

Concomitant administration of sucralfate and moxifloxacin significantly reduced the bioavailability of moxifloxacin. This reduction in bioavailability is likely due to a chelation reaction with polyvalent cations, which is a common finding for quinolones. Therefore, staggered administration of moxifloxacin and Al3+-containing interactants should be considered to avoid subtherapeutic plasma concentrations of the quinolone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Effects of iron supplements on the oral bioavailability of moxifloxacin, a novel 8-methoxyfluoroquinolone, in humans.

Author: StassH, KubitzaD

Reduced bioavailability

Concomitant administration of iron supplements and moxifloxacin significantly reduced the bioavailability of moxifloxacin. This reduction in bioavailability is likely due to a chelation reaction with polyvalent cations, which is a common finding for quinolones. Therefore, staggered administration of moxifloxacin and iron supplements should be considered to avoid subtherapeutic plasma concentrations of the quinolone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Thorough QT study of the effect of oral moxifloxacin on QTc interval in the fed and fasted state in healthy Japanese and Caucasian subjects.

Author: TaubelJorg, FerberGeorg, LorchUlrike, BatchvarovVelislav, SavelievaIrina, CammA John

Reduced QT prolongation
QT prolongation

This study investigated the effect of food on the QT prolongation caused by moxifloxacin in a TQT study and compared the QTc F profile of oral moxifloxacin in Japanese and Caucasian volunteers.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Unilateral acute iris transillumination like syndrome following intracameral moxifloxacin injection.

Author: ZubicoaAlicia, Echeverria-PalaciosMarta, Mozo CuadradoMarcos, Compains SilvaEsther

Moxifloxacin BAIT

A 53-year-old male developed unilateral acute iris transillumination and distorted pupil following cataract extraction with intracameral moxifloxacin injection. This case report suggests that BAIT-like syndrome may be a rare side effect of intracameral moxifloxacin.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

Safety and efficacy of intracameral moxifloxacin injection for prophylaxis of endophthalmitis after phacoemulsification.

Author: VieiraIbraim Viana, BoianovskyCelso, SaraivaThais Jones, GodoyRodolfo Bregion de, LakeJonathan

Endophthalmitis prevention

Intracameral injection of moxifloxacin after phacoemulsification and IOL implant significantly reduced the risk of endophthalmitis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Does moxifloxacin alter oxidant status in the cornea? An experimental study.

Author: AkalAli, UlasTurgay, GoncuTugba, GuldurMuhammet Emin, KocarslanSezen, TaskinAbdullah, SavikEmin, OzkanUfuk, KarakasEmel Yigit, KoksalMete, AksoyNurten

Systemic safety
Corneal toxicity

Intracameral moxifloxacin injection may have toxic effects on corneal tissue, as indicated by increased oxidative stress and apoptosis. However, it appears to be safe systemically.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Intraocular concentration of moxifloxacin after intracameral injection combined with presoaked intraocular lenses.

Author: LipnitzkiInna, Ben EliahuShmuel, MarcovitzArie L, EzovNatan, KleinmannGuy

High moxifloxacin levels

Implanting moxifloxacin-presoaked hydrophilic acrylic intraocular lenses resulted in high intraocular concentrations of the antibiotic. Longer presoaking times were associated with higher concentrations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Efficacy and safety of prophylactic intracameral moxifloxacin injection in Japan.

Author: MatsuuraKazuki, MiyoshiTeruyuki, SutoChikako, AkuraJunsuke, InoueYoshitsugu

Reduced risk of endophthalmitis

Intracameral moxifloxacin administration during cataract surgery significantly reduced the risk of endophthalmitis by 3-fold. In more than 18,000 cases, moxifloxacin administration of 500 μg/mL or less did not result in severe complications, such as toxic anterior segment syndrome or corneal endothelial cell loss.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

11.

Ocular pharmacokinetics, safety and efficacy of intracameral moxifloxacin 0.5% solution in a rabbit model.

Author: AsenaLeyla, AkovaYonca A, GoktaşMustafa T, BozkurtAtilla, YaşarUmit, KarabayGülten, DemiralayEbru

Effective for endophthalmitis prophylaxis
Safe for corneal endothelium

Intracameral moxifloxacin injection for endophthalmitis prophylaxis is a safe and effective method in uncomplicated phacoemulsification surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Treatment of experimental Bacillus cereus endophthalmitis using intravitreal moxifloxacin with or without dexamethasone.

Author: SakalarYildirim Bayezit, OzekinciSelver, CelenMustafa Kemal

Endophthalmitis treatment

Intravitreal moxifloxacin injection was effective in treating experimental Bacillus cereus endophthalmitis in rabbits. Adding intravitreal dexamethasone did not significantly improve treatment efficacy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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