D-penicillamine treatment of copper-associated hepatitis in Labrador retrievers.

Author: DirksenKaren, FietenHille, LeegwaterPeter A J, RothuizenJan, WatsonAdrian L, WinterEsther A, van den InghTed S G A M

Paper Details 
Original Abstract of the Article :
d-penicillamine is effectively used in the lifelong treatment of copper toxicosis in Bedlington terriers and Wilson's disease in humans. A complex form of copper-associated hepatitis has recently been characterized in the Labrador retriever. The aims of this study were to evaluate the effectiveness ...See full text at original site
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引用元:
https://doi.org/10.1016/j.tvjl.2012.12.013

データ提供:米国国立医学図書館(NLM)

D-penicillamine for Copper-Associated Hepatitis in Labrador Retrievers: A Tailored Approach

This research sheds light on the use of D-penicillamine in treating copper-associated hepatitis, a condition affecting Labrador retrievers. The study aimed to evaluate the efficacy of D-penicillamine treatment for this breed, analyze its effects on hepatic copper, iron, and zinc concentrations, and identify parameters for predicting optimal treatment duration. The researchers analyzed data from 43 Labrador retrievers diagnosed with elevated hepatic copper. Treatment with D-penicillamine was found to effectively reduce hepatic copper concentrations and associated inflammatory lesions. A model was developed to estimate the required duration of treatment, considering factors like initial hepatic copper concentration, sex, age, D-penicillamine formulation, and the occurrence of side effects. The researchers concluded that lifelong D-penicillamine treatment is not recommended for this breed, as it could lead to hepatic copper and zinc deficiency.

Personalized Treatment Strategies for Copper-Associated Hepatitis in Labrador Retrievers

This study highlights the need for personalized treatment approaches for copper-associated hepatitis in Labrador Retrievers. While D-penicillamine proves effective in reducing hepatic copper and inflammation, the research suggests that a tailored approach is necessary. The authors emphasize that lifelong D-penicillamine treatment may not be ideal due to the risk of copper and zinc deficiencies. Instead, the study emphasizes the importance of a carefully monitored treatment plan that considers individual factors like initial copper levels, age, and the presence of side effects. This approach aims to ensure optimal treatment while minimizing potential long-term complications.

Understanding Copper Metabolism and Its Impact on Labrador Retriever Health

This study underscores the importance of understanding copper metabolism in Labrador Retrievers. Copper is an essential mineral, but its accumulation in the liver can lead to serious health problems. This research sheds light on the potential risks associated with prolonged D-penicillamine treatment, including copper and zinc deficiencies. It highlights the need for continued research to develop more effective and safe treatment strategies for copper-associated hepatitis in this breed.

Dr.Camel's Conclusion

This study is a valuable contribution to our understanding of copper-associated hepatitis in Labrador Retrievers. Just like a camel adapts to the arid desert environment, these dogs have their own unique metabolic challenges. The study emphasizes the importance of personalized treatment strategies that account for individual factors and potential risks. It's a reminder that even in the vast field of veterinary medicine, careful consideration and a tailored approach are crucial for optimal patient care.

Date :
  1. Date Completed 2013-12-23
  2. Date Revised 2013-06-19
Further Info :

Pubmed ID

23375251

DOI: Digital Object Identifier

10.1016/j.tvjl.2012.12.013

Related Literature

SNS
PICO Info
in preparation
Languages

English

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