Side Effects of penicillamine: A Synthesis of Findings from 23 Studies

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Original Abstract of the Article

Major Research Findings

Penicillamine is a drug used to treat rheumatoid arthritis, Wilson's disease, and other conditions. However, it can cause a variety of side effects. , 23 , 14 , 17 , 2 , 5 , 7 , 11 , 6 , , 18 , 3 , , , 22 , 10 , 4 , 12 , 1 , , 9 , 15 , 20 , 21 , 19 , 8 , 16 ,

Reasons for Side Effects

Penicillamine can inhibit the production of collagen and elastin, proteins that are important for maintaining the structure of tissues such as skin and joints. 2 , 17 Therefore, taking penicillamine can lead to side effects such as thinning of the skin and joint pain. 2 , 18 Penicillamine can also affect the immune system. 14 , 2 , 4 , 19 As a result, taking penicillamine can lead to side effects such as allergic reactions and autoimmune diseases. 2 , 14 , 18 , 7 , 1 , 4 , 6 , 19

Common Side Effects

Skin

Penicillamine can affect the proteins in the skin, leading to various skin conditions. 2 , 18 Specifically, thinning of the skin, skin sagging, abnormal skin growth, and rashes have been reported. 2 , 18 , 15 , 7 , 1 , 12

Digestive System

Penicillamine can affect the digestive system. 2 , 3 Specifically, nausea, vomiting, abdominal pain, diarrhea, and loss of appetite have been reported. 2 , 3

Blood

Penicillamine can affect blood cells. 14 , 2 Specifically, leukopenia and thrombocytopenia have been reported. 14 , 2 , 3

Kidney

Penicillamine can affect the kidneys. 2 , 14 Specifically, proteinuria and nephritis have been reported. 2 , 14 , 11 , 19 , 6

Nerves

Penicillamine can affect the nervous system. 21 Specifically, neuropathy and taste disturbances have been reported. 21 , , 14

Other

In addition to the above, penicillamine can cause side effects such as hair loss, taste disturbances, liver dysfunction, and lung disorders. 2 , 14 , 5 , 3 , 7 , 23 , 20 , , 16 , 21

Side Effect Countermeasures

Blood

To minimize the effects of penicillamine on blood cells, regular blood tests should be performed and the dosage adjusted or discontinued as needed. 14 , 2

Kidney

To minimize the effects of penicillamine on the kidneys, regular urine tests should be performed and the dosage adjusted or discontinued as needed. 2 , 14

Skin

To minimize the effects of penicillamine on the skin, consult a doctor immediately if any abnormalities appear on the skin. 2 , 18

Other

Penicillamine can cause various side effects, so it is important to take it as directed by your doctor and undergo regular checkups. 2 , 3 , 14 , 22 , 21

Comparison Between Studies

Commonalities

Many studies have shown that penicillamine is effective in treating rheumatoid arthritis, Wilson's disease, and other conditions. 21 , 8 , 9 , 22 , , , 3 , , , 4 , 5 , , 23 However, they also show that it can cause a variety of side effects. 14 , 2 , 7 , 18 , 1 , 12 , 3 , , , , 4 , 6 , 19 , 11 , 20 , 15 , 21 The incidence of side effects varies from patient to patient and is thought to be individual-dependent. 3 , 2 , 4 , 6 Also, penicillamine side effects can be serious, so caution is required. 14 , 11 , 21

Differences

The incidence and types of side effects from penicillamine can vary depending on the study. 3 , 2 , 4 , 6 This is thought to be due to differences in the age and gender of the study subjects, the type of illness, the dosage of penicillamine, and the duration of treatment. 5 , 3 , 22

Things to Keep in Mind When Applying to Real Life

Penicillamine can cause a variety of side effects, so it is important to take it as directed by your doctor. 2 , 3 , 14 , 22 , 21 You should also undergo regular checkups when taking penicillamine. 2 , 3 , 14 , 22 Penicillamine can cause serious side effects, so be careful not to take it on your own judgment or stop taking it. 14 , 11 , 21

Limitations of Current Research

There is still not enough research on the side effects of penicillamine. 3 , 2 , 4 , 6 In particular, there are still many unknowns about the long-term effects of penicillamine. 5 , 3 , 22 Furthermore, more research is needed on how to reduce the side effects of penicillamine. 2 , 21

Future Research Directions

Further research is needed to better understand the side effects of penicillamine. 3 , 2 , 4 , 6 In particular, research on the long-term effects of penicillamine, the mechanisms by which side effects occur, and how to reduce side effects is important. 5 , 3 , 22 , 2 , 21

Conclusion

Penicillamine is an effective drug for treating rheumatoid arthritis, Wilson's disease, and other conditions, but it can cause a variety of side effects. 21 , 8 , 9 , 22 , , , 3 , , , 4 , 5 , , 23 The incidence of side effects varies from patient to patient, so it is important to consult with your doctor and undergo regular checkups. 3 , 2 , 4 , 6 Penicillamine side effects can be serious, so be careful not to take it on your own judgment or stop taking it. 14 , 11 , 21

Literature analysis of 23 papers
Positive Content
10
Neutral Content
4
Negative Content
9
Article Type
1
0
0
3
22
1.

[Cutaneous side effects induced by D-penicillamine in the treatment of rheumatoid arthritis].

Author: BrogginiM, BaratelliE, CappelliA, CrespiE, FilardiP G, VolontèS

Rheumatoid arthritis treatment
Drug-induced LES
Pemphigus
Skin rash

D-penicillamine is a drug used for rheumatoid arthritis that can cause skin side effects, including rashes and drug-induced pemphigus. The drug needs to be discontinued if these reactions occur.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Italian

2.

[D-penicillamine--side effects, pathogenesis and decreasing the risks].

Author: GrasedyckK

Allergy
Autoimmune issues
Blood problems
Contraindicated in bone marrow
liver and renal dysfunction
Contraindicated in pregnancy
GI issues
Hair loss
Proteinuria
Skin problems
Taste changes

D-penicillamine (DPA) is effective in treating rheumatoid arthritis but has a high incidence of side effects, including skin problems, blood disorders, gastrointestinal disturbances, and autoimmune phenomena. The total incidence of side effects is 30-60%, with a withdrawal rate of 20-30%.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

3.

[Side effects of d-penicillamine in the treatment of rheumatoid arthritis].

Author: MazzantiG, PaladiniG, DamianiD, BianchiniD, FloreanM, MesesnelE, CataldoR

Rheumatoid arthritis treatment
Side effects

d-Penicillamine was effective in treating rheumatoid arthritis. However, there were possible complications that required early detection.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Italian

5.

D-penicillamine in patients with rheumatoid arthritis. Serum levels, pharmacokinetic aspects, and correlation with clinical course and side effects.

Author: MuijsersA O, van de StadtR J, HenrichsA M, AmentH J, van der KorstJ K

Treats rheumatoid arthritis
None reported

D-penicillamine, a drug used to treat rheumatoid arthritis, has a half-life of 1.6 hours in the rapid phase and 4-6 days in the slow phase, suggesting tissue pooling.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

HLA system and side effects of gold salts and D-penicillamine treatment of rheumatoid arthritis.

Author: BardinT, DryllA, DebeyreN, RyckewaertA, LegrandL, MarcelliA, DaussetJ

Gold toxicity
Renal intolerance

Patients with the HLA haplotype A1 Cw7 B8 DR3 are more likely to experience gold toxic reactions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

Multiple side effects of penicillamine therapy in one patient with rheumatoid arthritis.

Author: EssigmanW K

Lupus
Myasthenia gravis
Myositis
Proteinuria
Skin rash

A patient with rheumatoid arthritis treated with penicillamine developed skin rashes, proteinuria, systemic lupus erythematosus, polymyositis, and myasthenia gravis. The skin lesion resembled elastosis perforans serpiginosa, a rare side effect of penicillamine in Wilson's disease but not in rheumatoid arthritis.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

[Clinical trial in couples of effectiveness and side-effects of gold and D-penicillamine in long term treatment of rheumatoid arthritis (author's transl)].

Author: HerrlingerJ D, KriegelW, DrewsJ, HölscherF, SchmidtR

Improved clinical course
Superior in long-term treatment
Serious complications
Side effects

Gold was found to be superior to D-penicillamine in treating rheumatoid arthritis, although both drugs have similar rates of side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

10.

[Immunologic studies with the lymphocyte transformation test on the side effects of D-penicillamine therapy in Wilson's disease].

Author: StorchW, BergerH

Immune stimulation

D-penicillamine did not disturb lymphocyte transformation in patients with Wilson's disease. Increased transformation rates to streptolysin-O in Wilson's disease need confirmation.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

11.

[Serious side effects with D-penicillamine therapy for Wilson's disease].

Author: StorchW, LössnerJ, RuchholtzU

Immunocomplex nephritis

Immunocomplex nephritis is a potential serious side effect of D-penicillamine treatment for Wilson's disease.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

12.

Skin and bone lesions (dermato-osteolathyrism), possible side effects of D-penicillamine treatment, in a boy with cystinuria.

Author: SteinmannB, OttenA, GitzelmannR

D-penicillamine side effects

D-penicillamine treatment for cystinuria and urolithiasis was partially successful. Side effects included flat feet, scoliosis, and molluscoid pseudotumors.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

Elastosis Perforans Serpiginosa: a D-penicillamine induced dermatoses in a patient with Wilson's disease.

Author: SamalSwagatika, SableMukund

Skin lesions
Systemic side effects

A 28-year-old male patient with Wilson's disease developed elastosis perforans serpiginosa as a side effect of long-term D-penicillamine treatment.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

16.

CRISPR/Cas9-mediated correction of mutated copper transporter ATP7B.

Author: PöhlerMichael, GuttmannSarah, NadzemovaOksana, LendersMalte, BrandEva, ZibertAndree, SchmidtHartmut H, SandfortVanessa

ATP7B correction
Gene therapy
Nephrotoxicity
Neurological deterioration

CRISPR/Cas9 gene editing may be a promising treatment for Wilson’s disease. The study successfully used CRISPR/Cas9 to correct a genetic mutation in human cells that causes Wilson’s disease. This finding suggests that gene editing could eventually be used to treat this potentially fatal condition.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Molecular Basis for the Interaction of Catalase with d-Penicillamine: Rationalization of Some of Its Deleterious Effects.

Author: PadovaniDominique, GalardonErwan

Rheumatoid arthritis treatment
Wilson's disease treatment
Side effects

This study investigated the molecular basis of d-penicillamine's side effects, focusing on its interaction with catalase. d-Penicillamine was found to inactivate catalase, potentially disrupting H2O2 redox homeostasis, which may contribute to the observed side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

D-penicillamine Induced Degenerative Dermopathy.

Author: KhandpurSujay, JainNaresh, SinglaShweta, ChatterjeePriti, BehariMadhuri

Wilson's disease treatment
Cutis laxa-like changes
Skin fragility

Two cases of Wilson's disease on long-term penicillamine therapy developed drug-induced degenerative dermopathy, manifesting as skin fragility and cutis laxa-like changes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Concomitant immune-related events in Wilson disease: implications for monitoring chelator therapy.

Author: SeessleJessica, GotthardtDaniel Nils, SchäferMark, GohdesAnnina, PfeiffenbergerJan, FerenciPeter, StremmelWolfgang, WeissKarl Heinz

Wilson disease treatment
Immune-mediated diseases

This study assessed the prevalence of co-existing or therapy-related immune-mediated diseases in Wilson disease patients and evaluated the role of antinuclear antibodies in therapy monitoring.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

Clinical considerations for an effective medical therapy in Wilson's disease.

Author: WeissKarl Heinz, StremmelWolfgang

Improved adherence
Reduced morbidity
Reduced side effects
Neurologic deterioration

Wilson's disease is a copper overload disorder that leads to hepatic and neurologic symptoms. This review discusses the need for standardized treatment options, including the importance of careful biochemical monitoring and symptom assessment using validated rating scales.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

23.

D-penicillamine treatment of copper-associated hepatitis in Labrador retrievers.

Author: FietenHille, DirksenKaren, van den InghTed S G A M, WinterEsther A, WatsonAdrian L, LeegwaterPeter A J, RothuizenJan

Copper toxicosis treatment
Hepatic copper and zinc deficiency

This study investigated the effectiveness of d-penicillamine, a medication used to treat copper toxicity, in Labrador retrievers with copper-associated hepatitis. The study found that d-penicillamine effectively reduced hepatic copper levels and inflammation, but it also suggested that long-term treatment might lead to copper and zinc deficiencies. Further research is needed to optimize treatment duration in this breed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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