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Effects of unprocessed versus vinegar-processed Schisandra chinensis on the activity and mRNA expression of CYP1A2, CYP2E1 and CYP3A4 enzymes in rats.

Author: LinYing, LuTulin, MaoChunqin, SongYu, SuTao, YinFangzhou, YuZhiling

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Schisandra chinensis is a traditional Chinese herb with potential health benefits. This study investigated the effects of unprocessed and vinegar-processed Schisandra chinensis on cytochrome P450 (CYP450) enzymes, which play a crucial role in drug metabolism. The study aimed to understand how different processing methods might affect the herb's interaction with other medications.
Paper Details　
Original Abstract of the Article :
Schisandra chinensis (SC) is a well-known traditional Chinese herbal medicine that has been used in clinical practices for thousands of years. However, the differences between the effects of unprocessed and vinegar-processed Schisandra chinensis (VSC) on cytochrome P450 (CYP450) activities are poorl...See full text at original site
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引用元：
https://doi.org/10.1016/j.jep.2013.01.028

データ提供：米国国立医学図書館（NLM）

The Desert of Herbal Medicine: Exploring the Effects of Schisandra chinensis

Traditional Chinese medicine offers a vast and intricate desert of knowledge, with many herbs and remedies passed down through generations. This study explores the effects of Schisandra chinensis (SC), a well-known traditional Chinese herb, on the activity and mRNA expression of cytochrome P450 (CYP450) enzymes, a group of enzymes essential for drug metabolism. The authors investigated the differences between the effects of unprocessed SC and vinegar-processed SC (VSC) on CYP450 enzymes, providing valuable insights into the potential interactions between SC and other medications.

The Shifting Sands of Metabolism: Understanding the Effects of SC

The study revealed that both unprocessed SC and VSC have the potential to influence CYP450 enzyme activity, suggesting potential interactions with other medications metabolized by these enzymes. The findings underscore the importance of considering potential drug interactions when using SC, particularly in individuals taking medications that are primarily metabolized by CYP450 enzymes. This research provides valuable insights into the potential benefits and risks of SC and its interactions with other drugs.

Navigating the Desert of Drug Interactions: Considerations for Herbal Medicine Use

This study highlights the importance of being aware of potential drug interactions when using herbal remedies, particularly those containing SC. The findings encourage open communication between patients and healthcare providers to ensure safe and effective treatment. The study encourages continued research to further explore the interactions between SC and other medications, providing a more comprehensive understanding of its pharmacological effects and potential risks.

Dr.Camel's Conclusion

This research offers a valuable reminder that the vast desert of traditional Chinese medicine holds a wealth of knowledge and potential benefits, but it is crucial to navigate this landscape with awareness and caution. The study underscores the importance of understanding potential drug interactions and the need for careful consideration when incorporating herbal remedies into treatment plans.

Date :
  1. Date Completed 2013-10-22
  2. Date Revised 2016-11-25
Further Info :

Pubmed ID

23376044

DOI: Digital Object Identifier

10.1016/j.jep.2013.01.028

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