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Role of recombinant human erythropoietin in mitomycin C-induced genotoxicity: analysis of DNA fragmentation, chromosome aberrations and micronuclei in rat bone-marrow cells.

Author: AbidSalwa, AchourAbdelatif, Ayed-BoussemaImen, BachaHassen, GuedriYosra, Rjiba-TouatiKarima

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Mitomycin C is a chemotherapy drug known for its effectiveness but can cause side effects. This study investigated whether erythropoietin, a hormone that stimulates red blood cell production, could protect against the DNA damage caused by mitomycin C in rat bone marrow cells. The study found that erythropoietin reduced the DNA damage induced by mitomycin C, particularly when given before treatment.
Paper Details　
Original Abstract of the Article :
Mitomycin C (MMC) is one of the most effective chemotherapeutic agents. However, during clinical use several side effects may occur. Recombinant human erythropoietin (rhEPO), a glycoprotein that regulates haematopoiesis, has been shown to exert an important cyto-protective effect in many tissues. Th...See full text at original site
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引用元：
https://doi.org/10.1016/j.mrgentox.2012.12.011

データ提供：米国国立医学図書館（NLM）

Protecting Bone Marrow Cells from the Harsh Effects of Mitomycin C

Mitomycin C (MMC) is a powerful chemotherapy drug, but it can come with some unwanted side effects. One such effect is damage to bone marrow cells. This study investigates the protective effects of recombinant human erythropoietin (rhEPO) on bone marrow cells exposed to MMC.

RhEPO: A Potential Shield for Bone Marrow Cells

The research found that rhEPO significantly reduced the harmful effects of MMC on bone marrow cells in rats. This protective effect was most pronounced when rhEPO was administered 24 hours before MMC treatment. These findings suggest that rhEPO might be a valuable tool for mitigating the harmful side effects of chemotherapy, particularly on bone marrow cells.

Toward Safer Chemotherapy

This research opens up possibilities for developing safer and more effective chemotherapy regimens. By using rhEPO as a protective agent, doctors may be able to minimize the damaging effects of chemotherapy on bone marrow cells, potentially improving the overall well-being of cancer patients.

Dr.Camel's Conclusion

This study reveals the potential of rhEPO as a protective agent against MMC-induced damage to bone marrow cells. This discovery holds significant promise for improving the safety and effectiveness of chemotherapy treatment, potentially leading to better outcomes for cancer patients.

Date :
  1. Date Completed 2013-07-16
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

23376209

DOI: Digital Object Identifier

10.1016/j.mrgentox.2012.12.011

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