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Pharmacokinetic comparison of two 4 mg tablet formulations of tizanidine.

Author: Al-GhazawiMutasim, AlzoubiMamoun, FaidiBashar

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Tizanidine PIC® 4 mg tablets are bioequivalent to Sirdalud® 4 mg tablets. Smoking was found to decrease the peak plasma concentration and area under the curve of tizanidine.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: To assess the bioequivalence of two Tizanidine 4 mg tablet formulations (Tizanidine® of the Pharma International company, as test product, and Sirdalud® of Novartis as a reference product), and to investigate possible effects of smoking on pharmacokinetics of tizanidine. METHODS: A sing...See full text at original site
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引用元：
https://doi.org/10.5414/CP201790

データ提供：米国国立医学図書館（NLM）

Pharmacokinetic comparison of two 4 mg tablet formulations of tizanidine

Tizanidine is a medication used to treat muscle spasms. This study compared the pharmacokinetic properties of two different 4 mg tablet formulations of tizanidine to determine if they were bioequivalent. The study also investigated the potential influence of smoking on tizanidine pharmacokinetics.

Bioequivalence of Tizanidine Formulations: A Detailed Examination

The study, involving 36 healthy volunteers, found that the two formulations of tizanidine were bioequivalent, meaning they were absorbed and metabolized in a similar way. The study also found that smoking reduced the peak plasma concentration and area under the curve of tizanidine, suggesting that smoking might affect the effectiveness of the medication. This study provides valuable information for healthcare professionals prescribing tizanidine, highlighting the importance of considering individual factors such as smoking habits when making treatment decisions.

Understanding Drug Absorption: A Desert of Pharmacokinetic Nuances

The world of drug absorption and metabolism is a complex and fascinating one, like a vast desert with hidden oases of knowledge. This study provides valuable insights into the pharmacokinetic properties of tizanidine, highlighting the importance of considering individual factors that can influence how the medication is absorbed and processed by the body.

Dr.Camel's Conclusion

This study delves into the fascinating world of drug pharmacokinetics. Just as a camel traverses a desert landscape, understanding how medications are absorbed and metabolized is crucial for ensuring optimal treatment outcomes. This study provides valuable insights into the bioequivalence of two tizanidine formulations and the potential influence of smoking on drug absorption.

Date :
  1. Date Completed 2013-06-18
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

23380428

DOI: Digital Object Identifier

10.5414/CP201790

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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