Efficacy and safety of continuous 4-year telbivudine treatment in patients with chronic hepatitis B.

Author: BaoW, ChanH L Y, GaneE J, HouJ, JiaJ, LiawY-F, NaoumovN V, NiuJ, PapatheodoridisG, ThongsawatS, TrylesinskiA, WanM, WangY

Paper Details 
Original Abstract of the Article :
In the phase-III GLOBE/015 studies, telbivudine demonstrated superior efficacy vs lamivudine during 2-year treatment in HBeAg-positive and HBeAg-negative chronic hepatitis B (CHB). After completion, 847 patients had an option to continue telbivudine treatment for further 2 years. A total of 596 (70%...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618368/

データ提供:米国国立医学図書館(NLM)

Telbivudine: A Long and Steady Journey Through the Desert of Hepatitis B

Hepatitis B, like a persistent desert wind, can cause chronic liver inflammation and damage. This study, like a research expedition charting a long and arduous course, explores the efficacy and safety of telbivudine, a potent antiviral drug, in treating chronic hepatitis B (CHB). The study, conducted over a four-year period, like a caravan traversing a vast expanse, followed 596 patients who had previously received telbivudine for two years. This research, like a meticulous analysis of the desert terrain, provides valuable insights into the long-term effectiveness of telbivudine in managing CHB.

Telbivudine's Endurance: A Beacon of Hope

The study, like a desert explorer uncovering a hidden oasis, revealed that telbivudine continued to effectively suppress the hepatitis B virus over four years. The study also observed a significant rate of HBeAg seroconversion, a crucial step towards recovery from CHB. This research, like a compass guiding towards a healthier future, offers hope for patients seeking a long-term solution to manage CHB. The study also highlighted a favorable safety profile for telbivudine, like a sturdy camel caravan navigating the desert safely.

Navigating the Desert of Hepatitis B: Implications for Patients

The findings of this study, like a map leading to a better future, provide valuable insights for patients seeking long-term management of CHB. Telbivudine, like a reliable source of water in a dry desert, has proven to be an effective and safe treatment option for many patients. This research, like a beacon of hope in a challenging landscape, reminds us that the journey to manage CHB is an ongoing one, requiring careful monitoring, proactive treatment, and a commitment to improving the lives of those affected.

Dr.Camel's Conclusion

Telbivudine, like a steadfast camel traversing the desert of hepatitis B, has shown impressive long-term efficacy and safety. This research, like a caravan finding a safe and reliable path, highlights the importance of continuous research and development in finding effective treatments for chronic diseases. It reminds us that the journey to manage chronic conditions is an ongoing one, requiring a commitment to patient care and a dedication to finding solutions for those in need.

Date :
  1. Date Completed 2013-08-28
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23490388

DOI: Digital Object Identifier

PMC3618368

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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