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Hepatoxicity of new antiretrovirals: a systematic review.

Author: LacombeKarine, SurgersLaure

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

The management of HIV has shifted towards earlier initiation of antiretroviral therapy, leading to lifelong drug exposure and concerns about long-term safety. Recent advances have introduced newer, safer, and more effective drugs. While initial antiretrovirals were associated with hepatotoxicity, newer drugs show reassuring liver tolerance in phase II/III trials. However, long-term data are needed, as case reports suggest rare but potentially life-threatening hepatic events in patients with co-infections or taking other hepatotoxic drugs.
Paper Details　
Original Abstract of the Article :
There has been a major paradigm shift in the management of HIV infected patients, with earlier initiation of antiretroviral treatment and lifelong exposure to drugs for which long-term safety issues must be faced by clinicians. Within the past 5 years, new drugs from both previously established and ...See full text at original site
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引用元：
https://doi.org/10.1016/j.clinre.2013.02.008

データ提供：米国国立医学図書館（NLM）

Navigating the Hepatotoxic Landscape of New Antiretrovirals: A Systematic Review

The development of new antiretrovirals has revolutionized the treatment of HIV infection. This systematic review, like a map charting the diverse terrain of a desert, examines the hepatotoxicity (liver toxicity) associated with these newer medications. The researchers aim to understand the potential risks and benefits of these drugs, ensuring their safe and effective use in patients.

Balancing Benefits and Risks

The review found that while newer antiretrovirals are generally considered safer than their predecessors, rare but potentially serious adverse hepatic events have been reported in some cases. This is like discovering hidden pockets of quicksand in a desert, requiring caution and vigilance. The review highlights the need for ongoing monitoring and research to ensure the long-term safety of these medications.

A Careful Approach to Treatment

This research underscores the importance of careful monitoring and risk assessment when prescribing new antiretrovirals. This is like a caravan leader carefully navigating a treacherous desert route, assessing the risks and making informed decisions to ensure the safety of their travelers. Clinicians must be aware of the potential hepatotoxic risks associated with these medications, especially in patients with pre-existing liver conditions or who are taking other hepatotoxic drugs.

Dr.Camel's Conclusion

This systematic review, like a seasoned desert guide, provides valuable information about the hepatotoxicity of new antiretrovirals. By understanding the potential risks and benefits of these medications, clinicians can make informed decisions that prioritize patient safety and optimize treatment outcomes.

Date :
  1. Date Completed 2014-01-24
  2. Date Revised 2021-08-26
Further Info :

Pubmed ID

23522569

DOI: Digital Object Identifier

10.1016/j.clinre.2013.02.008

SNS
PICO Info
in preparation
Languages

English

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