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Early upper digestive tract side effects of zidovudine with tenofovir plus emtricitabine in West African adults with high CD4 counts.

Author: AnglaretXavier, BohoussouFranck, CarrouJérome Le, DanelChristine, EholieSerge P, GabillardDelphine, KonanRomuald, MohRaoul, OuattaraEric, PeytavinGilles

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

An unexpectedly high rate of digestive serious adverse events (sAEs) was observed in West African adults, mostly women, who started a 3-nuc antiretroviral therapy (ART) with TDF/FTC+ZDV. This suggests that further early prescriptions of TDF+XTC+ZDV should be carefully monitored, and that whenever possible, the rate of early upper digestive adverse events should be compared to that occurring in patients taking other drug regimens.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: Tenofovir (TDF) with emtricitabine (FTC) and zidovudine (ZDV) is a recognized alternate first-line antiretroviral (ART) regimen for patients who cannot start treatment with non-nucleoside reverse transcriptase inhibitors (NNRTIs). Clinical studies comparing TDF+FTC+ZDV to other regimen...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643089/

データ提供：米国国立医学図書館（NLM）

Early Upper Digestive Tract Side Effects of Zidovudine with Tenofovir plus Emtricitabine in West African Adults

This research delves into the realm of antiretroviral therapy (ART) for HIV-infected individuals, specifically investigating the side effects of a particular ART regimen in West African adults. It's like exploring the complex landscape of HIV treatment, seeking to optimize regimens and minimize adverse effects. The study examines the early upper digestive tract side effects associated with the combination of tenofovir (TDF), emtricitabine (FTC), and zidovudine (ZDV) in a specific patient population.

Unexpectedly High Rate of Digestive Side Effects: A Cause for Concern

The study reveals an unexpectedly high rate of digestive side effects in West African adults starting treatment with TDF/FTC+ZDV. It's like encountering a hidden sandstorm in the desert of HIV treatment, one that requires careful navigation and attention. The findings highlight the need for closer monitoring of this ART regimen and further research to understand the underlying mechanisms driving these side effects.

Navigating the Desert of HIV Treatment: Finding the Optimal Path

This research underscores the importance of carefully monitoring the side effects of ART regimens, particularly in diverse populations. It's like having a vigilant guide to navigate the desert of HIV treatment, one that identifies potential pitfalls and adjusts the course accordingly. The study highlights the need for tailored approaches to ART, considering both the specific patient population and the potential for side effects.

Dr.Camel's Conclusion

This study provides a valuable reminder of the importance of carefully monitoring the side effects of ART regimens, particularly in diverse populations. It's like having a compass to guide us through the complex landscape of HIV treatment, ensuring that we choose the most appropriate paths for our patients. This research underscores the ongoing need for research and vigilance in the field of HIV treatment.
Date :
  1. Date Completed 2013-11-11
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23639243

DOI: Digital Object Identifier

PMC3643089

Related Literature

Article Analysis
・Side Effects of zdv
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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