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Clinical and genetic determinants of plasma nevirapine exposure following an intrapartum dose to prevent mother-to-child HIV transmission.

Author: , AcostaEdward P, ChanEllen S, HaasDavid W, HittiJane, HongFrancis, IvePrudence, KabandaJoseph, KumarasamyNagalingeshwaran, LallooUmesh, McMahonDeborah, OnekoOlola, RibaudoHeather J, SambareyPradeep, SeverePatrice, TauloFrank, VardhanabhutiSaran

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

The effects on plasma drug exposure following single-dose nevirapine may be greater for CYP2B6 983T → C than for 516G → T and are less pronounced than at steady state. Lower body mass index and random assignment to receive lopinavir/ritonavir were associated with more rapid nevirapine elimination.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: Nevirapine is metabolized by cytochrome P450 (CYP) 2B6 and CYP3A4. We characterized relationships between clinical parameters, human genetics, pharmacokinetics, and human immunodeficiency virus type 1 (HIV-1) drug resistance mutations in pregnant women following single-dose intrapartum ne...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719905/

データ提供：米国国立医学図書館（NLM）

Nevirapine and Mother-to-Child HIV Transmission: Unraveling the Genetic Landscape

The desert of HIV research is an ongoing quest for new treatments and preventative measures. This study examines the pharmacokinetics of nevirapine, a medication used to prevent mother-to-child HIV transmission, and its relationship to clinical parameters and genetic variations. The researchers, like skilled camel caravan guides, navigate the complex interplay of genetic factors and drug metabolism, seeking to optimize the effectiveness of nevirapine in preventing HIV transmission. This study delves into the intricate world of pharmacogenetics, offering valuable insights for improving HIV treatment strategies.

The Genetic Oasis: Uncovering the Influences on Nevirapine Metabolism

The study's findings, like a well-placed oasis in the desert of HIV research, reveal the influence of both clinical and genetic factors on nevirapine pharmacokinetics. These findings, like valuable stones discovered in the shifting sands, highlight the need for personalized medicine in HIV treatment, ensuring that patients receive the most effective therapy based on their individual genetic makeup.

Navigating the Desert of HIV Prevention: A Journey Towards Personalized Care

This study emphasizes the importance of understanding the complex relationship between genetic variations and drug metabolism in HIV prevention. The findings underscore the need for a personalized approach to nevirapine treatment, tailoring therapy to the individual genetic profile of each patient. This research could lead to more effective and targeted strategies for preventing mother-to-child HIV transmission, offering a brighter future for mothers and their babies.

Dr. Camel's Conclusion

This study highlights the significant influence of genetic variations on nevirapine pharmacokinetics, emphasizing the need for personalized medicine in HIV treatment. The findings offer valuable insights into the complex interplay of genetics and drug metabolism, paving the way for more effective and targeted strategies for preventing mother-to-child HIV transmission. This research serves as a beacon of hope in the ongoing fight against HIV, offering a roadmap towards a healthier future for mothers and their children.

Date :
  1. Date Completed 2013-09-30
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23687222

DOI: Digital Object Identifier

PMC3719905

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