Combined use of ionic liquid and hydroxypropyl-β-cyclodextrin for the enantioseparation of ten drugs by capillary electrophoresis.

Author: CuiYan, GuoXingjie, JiangZhen, MaXiaowei, XuShuying, ZhaoMin

Paper Details 
Original Abstract of the Article :
In the present study, hydroxypropyl-β-cyclodextrin and an ionic liquid (1-ethyl-3-methylimidazolium-l-lactate) were used as additives in capillary electrophoresis for the enantioseparation of 10 analytes, including ofloxacin, propranolol hydrochloride, dioxopromethazine hydrochloride, isoprenaline h...See full text at original site
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引用元:
https://doi.org/10.1002/chir.22168

データ提供:米国国立医学図書館(NLM)

Enantioseparation of Drugs: A Powerful Tool for Pharmaceutical Analysis

The field of pharmaceutical analysis is constantly seeking to refine techniques for separating and identifying different forms of molecules. This study investigates the use of a combined system of hydroxypropyl-β-cyclodextrin and an ionic liquid (1-ethyl-3-methylimidazolium-l-lactate) in capillary electrophoresis for enantioseparation of ten drugs. The researchers explore the synergistic effect of these additives in achieving high resolution separation of enantiomers, providing valuable insights for pharmaceutical analysis and quality control.

A Synergistic Approach to Enantioseparation: Combining Hydroxypropyl-β-cyclodextrin and Ionic Liquid

The study successfully demonstrates the synergistic effect of hydroxypropyl-β-cyclodextrin and the ionic liquid in enhancing enantioseparation. The researchers found that the cationic part of the ionic liquid played a key role in increasing resolution. This approach achieved successful separation of all ten drug enantiomers, highlighting the potential of this combined system for pharmaceutical analysis.

Enhancing Drug Purity and Quality Control: The Significance of Enantioseparation

This study underscores the importance of enantioseparation in pharmaceutical analysis and quality control. The ability to differentiate between different forms of molecules is crucial for ensuring the safety and efficacy of drugs. This research showcases the potential of a novel combined system for achieving high-resolution enantioseparation, contributing to advancements in pharmaceutical analysis and drug development.

Dr.Camel's Conclusion

Just as a camel navigates a desert landscape by carefully distinguishing different paths, pharmaceutical analysis relies on precise techniques to differentiate between different forms of molecules. This study demonstrates the effectiveness of a synergistic approach for achieving high-resolution enantioseparation, providing a powerful tool for pharmaceutical analysis and quality control. Remember, precision is key in ensuring the safety and efficacy of our medications!

Date :
  1. Date Completed 2014-03-13
  2. Date Revised 2017-11-16
Further Info :

Pubmed ID

23740623

DOI: Digital Object Identifier

10.1002/chir.22168

Related Literature

SNS
PICO Info
in preparation
Languages

English

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