Human erythrocytes as drug carriers: loading efficiency and side effects of hypotonic dialysis, chlorpromazine treatment and fusion with liposomes.

Author: BosmanG J C G M, BrockR, CluitmansJ C A, FavrettoM E

Paper Details 
Original Abstract of the Article :
Human red blood cells (RBCs) are emerging as a highly biocompatible microparticulate drug delivery system. So far, drugs have commonly been loaded into freshly isolated RBCs using rather disruptive methods based on hypotonic shock, and assessment of damage was restricted to hemolysis. Here, we inves...See full text at original site
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引用元:
https://doi.org/10.1016/j.jconrel.2013.05.032

データ提供:米国国立医学図書館(NLM)

Human Erythrocytes as Drug Carriers: A Journey Through the Body's Desert

Our [blood], like a vast desert, carries the vital resources necessary for our survival. This research explores the possibility of using [human red blood cells (RBCs)] as [drug carriers], transforming them into tiny, biocompatible vehicles that can traverse the body's landscape. This is a fascinating journey into the potential of harnessing our own biological systems for therapeutic purposes.

The researchers, like cartographers of the human body, investigated the efficiency and safety of various methods for loading drugs into RBCs, including [hypotonic dialysis, chlorpromazine treatment, and fusion with liposomes]. They sought to find the most effective and least disruptive ways to navigate this delicate terrain, ensuring that the drug delivery system remains intact and functional.

Optimizing the Journey: Finding the Right Delivery Route

The study's findings suggest that [chlorpromazine treatment and fusion with liposomes] offer more promising delivery routes for [drugs] compared to [hypotonic dialysis]. This is like finding a smoother, more efficient path through the desert, minimizing the risk of damage or disruption. These methods have the potential to enhance the efficacy and safety of drug delivery, making the journey through the body's desert more efficient and less taxing.

Navigating the Body's Desert: Safe and Effective Drug Delivery

This research opens exciting possibilities for the development of [novel drug delivery systems]. It highlights the potential of [RBCs] to serve as biocompatible, safe, and effective carriers, navigating the body's vast desert with precision and care. As we continue to explore the intricate pathways of the body's landscape, we may find even more innovative ways to harness its natural resources for therapeutic benefit.

Dr.Camel's Conclusion

This study offers a captivating glimpse into the potential of [human red blood cells] to serve as [drug delivery vehicles]. The researchers have uncovered promising strategies for optimizing this delivery system, opening new avenues for [therapeutic innovation] and [enhanced treatment efficacy]. This is a testament to the endless wonders of the human body, and the potential for harnessing its natural systems to create more effective and safe treatments.

Date :
  1. Date Completed 2014-03-11
  2. Date Revised 2013-08-12
Further Info :

Pubmed ID

23747798

DOI: Digital Object Identifier

10.1016/j.jconrel.2013.05.032

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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