Side Effects of chlorpromazine: A Synthesis of Findings from 5 Studies

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Original Abstract of the Article

Main Research Findings

Chlorpromazine is a drug used to treat mental illness, but it can cause various side effects. This article analyzes data from studies on chlorpromazine to provide a detailed explanation of its side effects.

Reasons for Side Effects

Chlorpromazine acts as a dopamine receptor antagonist, exerting its tranquilizing effect by blocking dopamine neurotransmission. However, dopamine plays a vital role in regulating motor function and emotions. Therefore, chlorpromazine can affect these functions as well, potentially causing side effects.

Common Side Effects

Extrapyramidal Symptoms

Chlorpromazine can induce extrapyramidal symptoms, as reported in 5 and 3 . These symptoms are characterized by abnormalities in motor function, such as muscle rigidity, tremors, and involuntary movements.

Eye Side Effects

Eye side effects associated with chlorpromazine have been reported in , 4 , and . These include lens capsule deposition, corneal pigmentation, and cataracts.

Other Side Effects

and report other side effects of chlorpromazine such as nausea, vomiting, constipation, weight gain, drowsiness, and dry mouth.

Side Effect Countermeasures

Extrapyramidal Symptoms

As reported in 5 , extrapyramidal symptoms can sometimes be alleviated by co-administering anticholinergic drugs like benztropine.

Eye Side Effects

Eye side effects can improve by discontinuing chlorpromazine. However, side effects that have already occurred may not completely heal.

Other Side Effects

Other side effects may be alleviated by adjusting the dosage of chlorpromazine or co-administering other medications.

Comparison between Studies

Commonalities in Studies

Numerous studies have shown that chlorpromazine is effective in treating mental illnesses, but it can also cause various side effects.

Differences in Studies

The incidence and types of side effects vary among studies. This is likely due to differences in the characteristics of study participants, dosage of chlorpromazine, co-administered medications, and other factors.

Precautions for Real-Life Applications

Chlorpromazine is an effective medication for treating mental illnesses, but the risk of side effects must also be considered. If you are taking chlorpromazine, always follow your doctor's instructions and consult your doctor immediately if you experience any side effects.

Limitations of Current Research

There is still insufficient research on the side effects of chlorpromazine. Further research is particularly needed regarding long-term side effects.

Future Research Directions

The development of new treatments and preventive measures to reduce the side effects of chlorpromazine is required. Research on the long-term effects of chlorpromazine is also important.

Conclusion

Chlorpromazine is an effective medication for treating mental illnesses, but it can cause various side effects. It is crucial to understand the risks of side effects and follow your doctor's instructions when taking chlorpromazine.

Literature analysis of 5 papers
Positive Content
3
Neutral Content
0
Negative Content
2
Article Type
0
0
0
0
5
1.

Novel chlorpromazine derivatives as anti-endometrial carcinoma agents with reduced extrapyramidal side effects.

Author: LiLijuan, LiuXiaohu, CuiYunxia, ChenYang, WuHuiwen, WangJing, GongXiaodi, GaoXiaoyan, YangLinlin, LiJian, SunXiao, MaoFei, WangYudong

Reduced EPSs
Stronger antitumor activity

This study investigates the antitumor activity of chlorpromazine (CPZ) derivatives against endometrial carcinoma (EC). The study found that CPZ derivatives 11·2HCl and 18 exhibited greater inhibitory activity than CPZ with less extrapyramidal side effects, suggesting their potential as a safer alternative for the treatment of EC.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Human erythrocytes as drug carriers: loading efficiency and side effects of hypotonic dialysis, chlorpromazine treatment and fusion with liposomes.

Author: FavrettoM E, CluitmansJ C A, BosmanG J C G M, BrockR

Drug delivery system
Hemolysis
Morphological changes
PS exposure

This study compared three methods for loading red blood cells with enzymes: hypotonic dialysis, chlorpromazine pretreatment, and liposome fusion. Liposome fusion and chlorpromazine pretreatment were found to be more efficient and less damaging to the red blood cells than hypotonic dialysis.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Extrapyramidal side effects in chlorpromazine recipients: emergence according to benztropine prophylaxis.

Author: SwettC, ColeJ O, ShapiroS, SloneD

Extrapyramidal symptoms

The frequency of extrapyramidal symptoms (EPS) attributed to chlorpromazine was compared in 86 patients receiving benztropine for EPS prevention and 568 patients receiving chlorpromazine alone. The study found no significant difference in the rate of EPS between the two groups, suggesting that prophylactic use of benztropine does not reduce the rate of EPS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

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