Conjugation to polymeric chains of influenza drugs targeting M2 ion channels partially restores inhibition of drug-resistant mutants.

Author: ChenJianzhu, KlibanovAlexander M, LarsonAlyssa M

Paper Details 
Original Abstract of the Article :
By attaching multiple copies of the influenza M2 ion channel inhibitors amantadine (1) and rimantadine (2) to polymeric chains, we endeavored to recover their potency in inhibiting drug-resistant influenza viruses. Depending on loading densities, as well as the nature of the drug, the polymer, and t...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/23832466

データ提供:米国国立医学図書館(NLM)

Fighting Drug-Resistant Influenza: A New Strategy for an Old Enemy

Influenza, a persistent foe, often adapts to overcome our defenses. This study, published in the journal [論文掲載誌], explores a novel strategy for combating drug-resistant strains of influenza. The authors present a clever solution: attaching multiple copies of influenza drugs to polymeric chains.

Polymer Conjugates: A New Weapon in the Fight Against Influenza

Think of this strategy as a sandstorm: a powerful force that can be harnessed to overcome obstacles. By attaching multiple copies of the influenza M2 ion channel inhibitors amantadine and rimantadine to polymeric chains, the researchers were able to significantly increase the potency of these drugs against drug-resistant strains of influenza. This approach is particularly noteworthy because it may help to salvage drugs that have lost their effectiveness due to viral resistance.

Hope for the Future: A New Path to Effective Influenza Treatment

The findings offer a glimmer of hope in the ongoing battle against influenza. While full recovery of inhibitory action against drug-resistant strains was not achieved in this study, it lays the foundation for future research that could lead to more effective influenza treatments. As Dr. Camel, I find this research particularly promising, as it highlights the importance of creative thinking and innovative approaches to tackle ever-evolving challenges.

Dr.Camel's Conclusion

This study demonstrates the power of innovation in the fight against infectious diseases. The researchers' creative approach, which involves attaching multiple copies of existing drugs to polymeric chains, offers a new path to effectively combat drug-resistant influenza strains. This research underscores the importance of staying one step ahead of our viral adversaries, a challenge that requires continuous exploration and adaptation.
Date :
  1. Date Completed 2014-03-03
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23832466

DOI: Digital Object Identifier

NIHMS494088

Related Literature

SNS
PICO Info
in preparation
Languages

English

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