Effects of rimantadine: A Synthesis of Findings from 22 Studies

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Original Abstract of the Article

Major Research Findings

Rimantadine is an antiviral medication that has been used to treat and prevent influenza A infections. 5 , 3 , 2 , 4 , 6 However, its use is limited due to concerns about potential side effects and a lack of understanding of its full value. 5 Research has shown that rimantadine can effectively prevent influenza A virus from entering cells, thus hindering infection. 16 Additionally, it has been discovered that rimantadine can enhance the effectiveness of other antiviral medications, such as neuraminidase inhibitors, when used in combination. 16

Benefits and Risks

Benefits Summary

Rimantadine has shown promise in both preventing and treating influenza A infections. 5 , 3 , 2 , 4 , 6 The drug's mechanism of action involves hindering the influenza A virus from entering cells, effectively preventing infection. 16 Furthermore, combining rimantadine with other antiviral drugs, such as neuraminidase inhibitors, has shown potential for increased effectiveness against influenza A. 16

Risks Summary

Rimantadine, like many medications, can cause side effects, including dizziness, drowsiness, nausea, and digestive issues. 1 , 5 Additionally, it may have potential impacts on the nervous system. 1 A notable concern is the possibility of influenza A viruses developing resistance to rimantadine. 11 , 9 , 8 , 22 , 19

Comparison of Studies

Commonalities Among Studies

Multiple studies have confirmed that rimantadine is effective against influenza A virus. 5 , 3 , 2 , 4 , 6 Moreover, research suggests that combining rimantadine with neuraminidase inhibitors may amplify its effectiveness. 16 The drug works by hindering the influenza A virus from entering cells, thus preventing infection and mitigating the severity of symptoms. 5 Combining rimantadine with neuraminidase inhibitors presents a potential strategy for more effective treatment of influenza A infections. 16

Differences Among Studies

While the effectiveness of rimantadine against influenza A virus is established, the extent of its efficacy varies across different studies. 5 , 3 , 2 , 4 , 6 Furthermore, a significant concern is the potential for influenza A viruses to develop resistance to rimantadine. 11 , 9 , 8 , 22 , 19

Consistency and Contradictions in Findings

Research consistently shows that rimantadine is effective against influenza A virus. 5 , 3 , 2 , 4 , 6 However, some studies highlight the potential for the emergence of influenza A viruses resistant to rimantadine. 11 , 9 , 8 , 22 , 19

Considerations for Applying Research in Real-Life

While research shows rimantadine's effectiveness against influenza A, it's crucial to remember the potential side effects. 1 , 5 Furthermore, the development of influenza A strains resistant to rimantadine is a concern. 11 , 9 , 8 , 22 , 19 If you are considering taking rimantadine, consulting a doctor is essential to weigh the benefits and risks and determine if it is the right treatment for you.

Limitations of Current Research

There is still much to be learned about the effects of rimantadine. 5 , 3 , 2 , 4 , 6 Further research is needed to gain a more comprehensive understanding of rimantadine's effects and potential applications. 5 , 3 , 2 , 4 , 6

Future Research Directions

To deepen our knowledge of rimantadine's effects, further research is crucial. 5 , 3 , 2 , 4 , 6 In particular, research needs to focus on understanding if rimantadine is effective against influenza A strains that have developed resistance to the drug. 11 , 9 , 8 , 22 , 19

Conclusion

Rimantadine has demonstrated its effectiveness against influenza A virus. 5 , 3 , 2 , 4 , 6 However, it's important to be aware of potential side effects. 1 , 5 Additionally, the emergence of influenza A strains resistant to rimantadine is a concern. 11 , 9 , 8 , 22 , 19 If you are considering taking rimantadine, it is crucial to consult a doctor to discuss the benefits, risks, and whether it is the right treatment option for you.

Literature analysis of 22 papers
Positive Content
22
Neutral Content
0
Negative Content
0
Article Type
1
1
5
9
22
1.

Double-blind controlled study of central nervous system side effects of amantadine, rimantadine, and chlorpheniramine.

Author: MilletV M, DreisbachM, BrysonY J

No effect on cognitive performance
Enhanced side effects with combination therapy
Side effects

Amantadine, rimantadine, and chlorpheniramine did not affect cognitive performance in 52 healthy volunteers. Subjective side effects were minimal and comparable across groups. Combining amantadine and chlorpheniramine appeared to enhance side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

2.

Amantadine and rimantadine for preventing and treating influenza A in adults.

Author: JeffersonT O, DemicheliV, DeeksJ J, RivettiD

Antiviral properties
Adverse effects

This review assesses the effects and safety of amantadine and rimantadine in healthy adults. These antiviral drugs are not widely used due to a lack of knowledge and concerns about potential adverse effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

3.

Amantadine and rimantadine for preventing and treating influenza A in adults.

Author: JeffersonT O, DemicheliV, DeeksJ J, RivettiD

Influenza prevention
Influenza treatment
CNS side effects
Gastrointestinal side effects

Amantadine and rimantadine have comparable effectiveness in the prevention and treatment of influenza A in healthy adults, although rimantadine induces fewer adverse effects than amantadine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Amantadine and rimantadine for preventing and treating influenza A in adults.

Author: JeffersonT O, DemicheliV, DeeksJ J, RivettiD

Prevents influenza
Reduces fever duration
Central nervous system effects
Gastrointestinal effects

Amantadine and rimantadine have comparable effectiveness in the prevention and treatment of influenza A in healthy adults, although rimantadine induces fewer adverse effects than amantadine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

Amantadine and rimantadine for preventing and treating influenza A in adults.

Author: JeffersonT, DeeksJ J, DemicheliV, RivettiD, RudinM

Influenza A prevention
Influenza A treatment
Central nervous system side effects
Gastrointestinal side effects

This review assessed the effectiveness and safety of amantadine and rimantadine in healthy adults. The review found that both drugs were effective in preventing and treating influenza A, but that amantadine was associated with more adverse effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

6.

Amantadine and rimantadine for influenza A in adults.

Author: JeffersonT, DemicheliV, Di PietrantonjC, RivettiD

Fever reduction
Influenza prevention
Gastrointestinal side effects

Amantadine and rimantadine are comparably effective in treating symptoms of influenza A in healthy adults, although rimantadine induces fewer adverse effects than amantadine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

7.

[Adamantan derivatives capable of inhibiting the reproduction of a Rimantadine resistant strain of influenza A(H1N1)pdm09 virus (Influenza A virus, Alphainfluenzavirus, Orthomyxoviridae).]

Author: GaraevT M, OdnovorovA I, KirillovaE S, BurtsevaE I, FinogenovaM P, MukashevaE A, GrebennikovaT V

influenza treatment
drug resistance

New adamantane derivatives have antiviral properties against the pandemic strain of influenza A virus in vitro.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Russian

10.

Adamantane - A Lead Structure for Drugs in Clinical Practice.

Author: SpilovskaKatarina, ZemekFilip, KorabecnyJan, NepovimovaEugenie, SoukupOndrej, WindischManfred, KucaKamil

Adamantane derivatives
Various therapeutic indications
Adamantane side effects

Adamantane derivatives are effective in treating a wide range of conditions, including viral infections, diabetes, and neurodegenerative diseases.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

11.

Conjugation to polymeric chains of influenza drugs targeting M2 ion channels partially restores inhibition of drug-resistant mutants.

Author: LarsonAlyssa M, ChenJianzhu, KlibanovAlexander M

Influenza treatment

This study aimed to improve the effectiveness of amantadine and rimantadine against drug-resistant influenza viruses by attaching multiple copies of these drugs to polymeric chains. The results showed that the polymer-conjugated drugs were up to 30 times more potent than their monomeric parents against drug-resistant strains, particularly when a 20% loading density and a short linker group on the negatively charged poly-l-glutamate were used.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Patch-Clamp Study of Hepatitis C p7 Channels Reveals Genotype-Specific Sensitivity to Inhibitors.

Author: BreitingerUlrike, FaragNoha S, AliNourhan K M, BreitingerHans-Georg A

Hepatitis C treatment

This study investigated the properties of the hepatitis C virus (HCV) p7 protein, an intracellular ion channel involved in viral replication, using patch-clamp recording techniques. The study found that amantadine exhibited significant, genotype-specific variation in its inhibition of p7-mediated currents.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release.

Author: FosterToshana L, ThompsonGary S, KalverdaArnout P, KankanalaJayakanth, BenthamMatthew, WetherillLaura F, ThompsonJoseph, BarkerAmy M, ClarkeDean, NoerenbergMarko, PearsonArwen R, RowlandsDavid J, HomansSteven W, HarrisMark, FosterRichard, GriffinStephen

Broadening DAA targets
Suppression of rimantadine resistance polymorphisms

This research describes the complete structure of the HCV p7 protein, a viroporin essential for viral infection, and identifies a novel allosteric site on the channel periphery. This discovery led to the development of potent, structurally diverse inhibitory small molecules with nanomolar potency, demonstrating a 10,000-fold improvement over existing prototypes. These compounds exhibit activity against various HCV genotypes and suppress rimantadine resistance polymorphisms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Anti-influenza Virus Effects of Catechins: A Molecular and Clinical Review.

Author: IdeKazuke, KawasakiYohei, KawakamiKoji, YamadaHiroshi

Anti-influenza agent

This review discusses the potential of tea catechins, specifically (-)-epigallocatechin gallate (EGCG), as antiviral agents against influenza infection. EGCG has been shown to inhibit influenza virus infection in vitro and exhibits neuraminidase inhibitory activity. Future research on catechin derivatives may lead to the development of effective influenza prevention and treatment strategies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

18.

Clinical Implications of Antiviral Resistance in Influenza.

Author: LiTimothy C M, ChanMartin C W, LeeNelson

Influenza treatment
Antiviral resistance

Antiviral resistance is a major concern with the treatment of influenza. This review focuses on neuraminidase inhibitors (NAIs), a class of antiviral drugs used to treat influenza. The review discusses primary resistance, secondary resistance related to NAI exposure, clinical implications, detection of resistance, and novel therapeutic options currently undergoing clinical trials.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

19.

X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance.

Author: ThomastonJessica L, KonstantinidiAthina, LiuLijun, LambrinidisGeorge, TanJingquan, CaffreyMartin, WangJun, DegradoWilliam F, KolocourisAntonios

Inhibition of proton conductance
Adamantane resistance

This study used X-ray crystallography to determine the structures of a spiro-adamantyl amine inhibitor bound to the influenza A matrix 2 (M2) proton channel V27A mutant. The results showed that the V27A mutation widens the channel pore and alters the inhibitor's binding site, explaining its resistance to adamantane antiviral drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

[The antiviral activity of the adamantane derivatives against the influenza virus A (H1N1) pdm2009 model in vivo].

Author: ShchelkanovM Iu, ShibnevV A, FinogenovaI T, FediakinaT M, GaraevT M, MarkovaN V, KirillovI M

Antiviral activity
Influenza A treatment

This study investigated the antiviral activity of synthetic derivatives of adamantane against influenza A virus (H1N1) pdm09 in a mouse model of viral pneumonia. The findings suggest that adamantane derivatives with histidine, serine, and lipoid acid may inhibit rimantadine-resistant strains.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Russian

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