Clearance of meperidine and its metabolite normeperidine in hemodialysis patients with chronic noncancer pain.

Author: HoShung-Tai, HsuChe-Hao, LinShih-Hua, LinTso-Chou, LuChih-Cherng

Paper Details 
Original Abstract of the Article :
CONTEXT: Normeperidine accumulates in patients with impaired renal function and may cause central neurotoxicity. However, some uremic patients still undergo meperidine treatment for chronic pain. OBJECTIVES: To prevent normeperidine side effects and complications, we investigated the clearance rate...See full text at original site
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引用元:
https://doi.org/10.1016/j.jpainsymman.2013.05.007

データ提供:米国国立医学図書館(NLM)

Hemodialysis: A Desert Oasis for Meperidine Clearance

Meperidine, a pain reliever, can pose challenges for patients with impaired kidney function, leading to the accumulation of a toxic metabolite, normeperidine. This study investigates the effectiveness of hemodialysis in removing both meperidine and normeperidine from the blood of patients with chronic noncancer pain. The authors monitored the plasma concentrations of both substances before, during, and after hemodialysis sessions, demonstrating that hemodialysis significantly reduces their levels. This research provides valuable insights into the potential of hemodialysis in managing meperidine therapy in patients with renal impairment.

A Vital Tool for Kidney Patients: Hemodialysis for Drug Clearance

The study's findings emphasize the importance of hemodialysis in managing meperidine therapy for patients with chronic noncancer pain and renal impairment. This vital procedure, like a refreshing oasis in the desert, provides a pathway to safely remove potentially toxic substances from the body. It's crucial to consult with a healthcare professional to determine the most appropriate treatment plan for your individual needs.

Navigating the Desert of Kidney Disease: Hemodialysis as a Life Raft

Hemodialysis plays a crucial role in managing the health of individuals with kidney disease. It's like a life raft in a vast desert, providing a means to sustain life and manage the challenges associated with renal impairment. By understanding the role of hemodialysis in drug clearance, patients can make informed decisions about their treatment plans.

Dr.Camel's Conclusion

This research highlights the importance of hemodialysis in managing drug therapy for patients with kidney disease. It's like finding a hidden oasis in the desert of medical challenges, offering a lifeline for those in need. Hemodialysis provides a vital tool for managing medication levels and improving the overall health of kidney patients.

Date :
  1. Date Completed 2015-04-02
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

23870842

DOI: Digital Object Identifier

10.1016/j.jpainsymman.2013.05.007

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SNS
PICO Info
in preparation
Languages

English

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