Cutaneous side effects of combined therapy with sorafenib and pegylated interferon alpha-2b in metastatic melanoma (phase II DeCOG trial).

Author: DegenAnnette, EgbertsFriederike, GarbeClaus, GutzmerRalf, HauschildAxel, KilianKatharina, PoppeLìdia Marilia, TrefzerUwe, UgurelSelma, WeichenthalMichael

Paper Details 
Original Abstract of the Article :
During a clinical study with combined therapy of sorafenib and pegylated interferon alpha-2b (SoraPeg study) of the German Dermatologic Oncology Group (ADO/DeCOG), multiple and severe cutaneous side effects were observed. This study sought to analyze these cutaneous side effects, particularly becaus...See full text at original site
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引用元:
https://doi.org/10.1111/ddg.12100

データ提供:米国国立医学図書館(NLM)

Sorafenib and Pegylated Interferon Alpha-2b: A Desert Oasis with Unexpected Storms

Metastatic melanoma, a type of skin cancer, can spread like a desert sandstorm, posing a serious threat to health. This study investigates the combination therapy of sorafenib and pegylated interferon alpha-2b, exploring its effectiveness and potential side effects.

Sorafenib and Pegylated Interferon Alpha-2b: A Double-Edged Sword

Sorafenib, a targeted therapy, acts like a desert rain, hindering the growth of cancer cells. Pegylated interferon alpha-2b, an immune modulator, acts like a desert wind, stimulating the immune system to fight the cancer. This study found that while this combination therapy can be effective, it can also lead to significant cutaneous side effects, like unexpected storms in a seemingly peaceful oasis.

Navigating the Desert with Caution: Understanding Potential Risks

The findings of this study highlight the importance of being aware of the potential side effects of combination therapies. While sorafenib and pegylated interferon alpha-2b can offer benefits in battling melanoma, it's crucial to carefully monitor patients for any adverse reactions and to weigh the risks and benefits carefully. Remember, every desert has its own hidden dangers, and navigating this terrain requires a cautious and informed approach.

Dr. Camel's Conclusion

This study explores the combination therapy of sorafenib and pegylated interferon alpha-2b for metastatic melanoma. While this approach can be effective, it's essential to be aware of potential cutaneous side effects and to manage them effectively, ensuring a smoother journey through the desert of cancer treatment.

Date :
  1. Date Completed 2014-05-05
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

23879405

DOI: Digital Object Identifier

10.1111/ddg.12100

Related Literature

SNS
PICO Info
in preparation
Languages

English

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