Effects of prophylactic and therapeutic teriflunomide in transcranial magnetic stimulation-induced motor-evoked potentials in the dark agouti rat model of experimental autoimmune encephalomyelitis.

Author: HanakSusan, Iglesias-BregnaDeborah, JiZhongqi, LiuLi, McMonagle-StruckoKathleen, PettyMargaret, ZhangDonghui

Paper Details 
Original Abstract of the Article :
Teriflunomide is a once-daily oral immunomodulatory agent recently approved in the United States for the treatment of relapsing multiple sclerosis (RMS). This study investigated neurophysiological deficits in descending spinal cord motor tracts during experimental autoimmune encephalomyelitis (EAE; ...See full text at original site
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引用元:
https://doi.org/10.1124/jpet.113.205146

データ提供:米国国立医学図書館(NLM)

Teriflunomide's Impact on Motor-Evoked Potentials in Experimental Autoimmune Encephalomyelitis

Multiple sclerosis (MS) is a complex and debilitating neurological condition, like a desert storm that disrupts the delicate pathways of the brain. This study investigates the effects of teriflunomide, an immunomodulatory agent, on motor function in a rat model of experimental autoimmune encephalomyelitis (EAE), a model of MS. The researchers examined the impact of both prophylactic and therapeutic teriflunomide treatment on motor-evoked potentials, a measure of nerve function. The study found that teriflunomide significantly reduced EAE disease scores and prevented deficits in descending spinal cord motor tracts, suggesting its potential for treating MS.

Fighting the Desert Storm: Teriflunomide's Potential in Treating Multiple Sclerosis

The study highlights the potential of teriflunomide in treating MS, specifically its ability to mitigate motor function deficits. The findings suggest that teriflunomide could be a valuable tool for managing MS, potentially slowing disease progression and improving quality of life. It's like a desert traveler finding a resilient camel breed, able to withstand the harsh conditions and navigate the challenging terrain.

Navigating the Desert of MS: Understanding Treatment Options and Research

MS is a complex and challenging condition. This study highlights the importance of ongoing research in finding effective treatments. Teriflunomide shows promise as a potential therapeutic agent for MS, offering hope for individuals struggling with this debilitating disease. It's like discovering a hidden oasis in the desert, providing a respite from the harsh realities of MS.

Dr. Camel's Conclusion

This study explores the potential of teriflunomide in treating MS and provides valuable insights into the complex mechanisms underlying this neurological condition. It emphasizes the importance of ongoing research and the search for effective treatments for MS. As a wise camel traveler, I always encourage individuals facing MS to seek the best possible care and support.

Date :
  1. Date Completed 2013-11-25
  2. Date Revised 2022-03-10
Further Info :

Pubmed ID

23892570

DOI: Digital Object Identifier

10.1124/jpet.113.205146

Related Literature

SNS
PICO Info
in preparation
Languages

English

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