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Anaplastic oligodendroglioma: a new treatment paradigm and current controversies.

Author: RothPatrick, WellerMichael, WickWolfgang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Anaplastic oligodendroglial tumors benefit from combined radiation therapy (RT) and chemotherapy, particularly for those with 1p/19q co-deletion. The combination of procarbazine/lomustine/vincristine (PCV) chemotherapy with RT has shown to extend survival in these patients. Temozolomide, an alternative to PCV, may have a more favorable side effect profile, but further research is needed to confirm its efficacy.
Paper Details　
Original Abstract of the Article :
Anaplastic oligodendroglial tumors have gained increasing interest with the emerging role of molecular markers and systemic chemotherapy during the past years. The long-term results of two landmark trials, RTOG 9402 and EORTC 26961, have resulted in a reconsideration of the appropriate therapeutic a...See full text at original site
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引用元：
https://doi.org/10.1007/s11864-013-0251-7

データ提供：米国国立医学図書館（NLM）

Anaplastic Oligodendroglioma: A New Era of Treatment

This research delves into the complex world of brain tumors, focusing on anaplastic oligodendroglial tumors, a type of brain cancer. The authors discuss the emerging role of molecular markers and systemic chemotherapy in treating this aggressive tumor. They review the results of two landmark trials, RTOG 9402 and EORTC 26961, which have led to a shift in treatment paradigms for anaplastic oligodendroglioma. This research is vital for understanding the latest advancements in treating this challenging brain tumor and improving patient outcomes.

Molecular Markers and Treatment: A Personalized Approach

The research highlights the importance of molecular markers, specifically the 1p/19q co-deletion, in determining the most effective treatment approach for anaplastic oligodendroglioma. Patients with co-deleted tumors benefit significantly from the addition of procarbazine/lomustine/vincristine (PCV) chemotherapy to radiation therapy (RT). This personalized approach to treatment is crucial for maximizing the effectiveness of therapy.

Navigating Brain Tumor Treatment: Staying Informed and Empowered

This research underscores the importance of staying informed about the latest advancements in brain tumor treatment. It's crucial to consult with a qualified healthcare professional to understand the specific treatment options available for your individual situation.

Dr.Camel's Conclusion

This research, like a camel navigating a treacherous desert path, sheds light on the evolving landscape of anaplastic oligodendroglioma treatment. The study highlights the importance of molecular markers and personalized therapy for this challenging brain tumor.

Date :
  1. Date Completed 2014-08-18
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23907441

DOI: Digital Object Identifier

10.1007/s11864-013-0251-7

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Article Analysis
・Side Effects of lomustine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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