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Liposomal-lupane system as alternative chemotherapy against cutaneous leishmaniasis: macrophage as target cell.

Author: BarrosNeuza B, CiancagliniPietro, FacundoValdir A, MigliaccioVanessa, NicoleteRoberto, Silva-JardimIzaltina, StábeliRodrigo G

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Liposomal lupane has potential as a new treatment for Leishmania amazonensis infection, showing efficacy in infected macrophages.
Paper Details　
Original Abstract of the Article :
Leishmania amazonensis causes human diseases that range from self-healing to diffusion cutaneous lesions. The chemotherapy of leishmaniasis requires long-term treatment and has been based on the use of pentavalent antimonials. Liposomes have been used as antileishmanial drug carries and have adjuvan...See full text at original site
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引用元：
https://doi.org/10.1016/j.exppara.2013.07.022

データ提供：米国国立医学図書館（NLM）

Liposomal-Lupane System for Cutaneous Leishmaniasis

The vast desert of tropical medicine presents unique challenges. This research focuses on cutaneous leishmaniasis, a parasitic disease that causes skin lesions. The study investigates a novel approach for treating the disease, utilizing a liposomal formulation containing lupane, a natural compound with anti-leishmanial properties.

Liposomal-Lupane System: A New Therapeutic Strategy

The researchers developed a liposomal formulation containing lupane, a natural compound isolated from the fruits of Combretum leprosum. This is like encasing a potent medicinal ingredient in a protective capsule, ensuring its safe and effective delivery to the target area. The study evaluated the efficacy of liposomal-lupane in a mouse model of Leishmania amazonensis infection.

Implications for Leishmaniasis Treatment

This research presents a promising new approach for treating cutaneous leishmaniasis. The liposomal-lupane system, like a skilled desert traveler carrying a precious remedy, could offer a more effective and potentially safer treatment option, reducing the need for long-term and often toxic treatments.

Dr. Camel's Conclusion

This study explores a new frontier in the treatment of cutaneous leishmaniasis. The liposomal-lupane system offers a beacon of hope in the desert of parasitic diseases, potentially leading to improved therapeutic strategies and enhanced patient outcomes.
Date :
  1. Date Completed 2013-12-05
  2. Date Revised 2013-10-14
Further Info :

Pubmed ID

23933281

DOI: Digital Object Identifier

10.1016/j.exppara.2013.07.022

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Languages

English

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