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Varenicline for smoking cessation among methadone-maintained smokers: a randomized clinical trial.

Author: AndersonB J, AudetD, CavinessC M, KurthM E, OlsonJ, SteinM D

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

Varenicline did not increase quit rates over placebo in methadone-maintained smokers. Smoking cessation rates in this population remain low, highlighting the need for novel treatment strategies.
Paper Details　
Original Abstract of the Article :
BACKGROUND: With smoking rates far exceeding the general population, methadone-maintained (MMT) opiate-dependent smokers experience high rates of tobacco-related health consequences. Previous treatment studies have used nicotine replacement and produced low quit rates. METHODS: We test, using a thr...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/23953658

データ提供：米国国立医学図書館（NLM）

Varenicline for Smoking Cessation: A Challenging Quest in Methadone-Maintained Smokers

This study investigates the efficacy of varenicline, a medication for smoking cessation, in methadone-maintained (MMT) opiate-dependent smokers. The researchers conducted a randomized clinical trial to compare varenicline to placebo and nicotine replacement therapy (NRT) in promoting smoking cessation among this high-risk population.

Varenicline's Effectiveness in Methadone-Maintained Smokers

The study found that varenicline did not significantly increase quit rates over placebo in MMT smokers. While NRT showed a higher quit rate, the overall cessation rates remained low, highlighting the challenges of smoking cessation in this population.

Addressing Smoking Cessation in High-Risk Populations

Smoking cessation is a critical public health issue, particularly in high-risk populations like MMT smokers. This research highlights the need for novel and effective treatment strategies to address the challenges of smoking cessation among this group, improving their health outcomes and reducing tobacco-related morbidity and mortality.

Dr.Camel's Conclusion

This study explores the challenges of smoking cessation in methadone-maintained smokers, highlighting the need for innovative approaches to address this complex issue. It's like navigating a treacherous desert landscape, where every step requires careful consideration and adaptive strategies. This research emphasizes the importance of finding more effective and tailored interventions to help MMT smokers break free from nicotine dependence and improve their health outcomes.

Date :
  1. Date Completed 2014-06-23
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23953658

DOI: Digital Object Identifier

NIHMS516423

Related Literature

Article Analysis
・Effective treatment of smoking
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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