Desferrioxamine mesylate for managing transfusional iron overload in people with transfusion-dependent thalassaemia.

Author: BrunskillSusan J, ChowdhuryOnima, DoreeCarolyn, FisherSheila A, GoodingSarah, RobertsDavid J

Paper Details 
Original Abstract of the Article :
Thalassaemia major is a genetic disease characterised by a reduced ability to produce haemoglobin. Management of the resulting anaemia is through red blood cell transfusions.Repeated transfusions result in an excessive accumulation of iron in the body (iron overload), removal of which is achieved th...See full text at original site
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引用元:
https://doi.org/10.1002/14651858.CD004450.pub3

データ提供:米国国立医学図書館(NLM)

Treating Transfusional Iron Overload in Thalassaemia: A Desferrioxamine Journey

Thalassaemia major is a genetic disorder that affects the production of haemoglobin, leading to a reliance on blood transfusions. This study investigates the use of desferrioxamine mesylate (desferrioxamine), a medication for managing iron overload, a common consequence of repeated transfusions. It's like navigating a desert with the threat of iron overload - the study explores ways to remove excess iron and prevent its harmful effects.

A Balancing Act: Desferrioxamine and Iron Chelation

While desferrioxamine has been proven effective in removing excess iron, adherence to the treatment can be challenging. The study points to the challenges of managing iron overload, comparing the effectiveness of desferrioxamine with other iron chelators. It's a delicate balancing act, finding the right treatment regimen to manage the iron levels while minimizing side effects.

Seeking Better Options for Management

This study underscores the importance of ongoing research into more effective and tolerable treatments for iron overload in thalassaemia. The study highlights the need for alternative iron chelators and new approaches to manage the condition. It's a reminder that the desert of thalassaemia is vast and complex, requiring persistent efforts to develop better treatments and improve the lives of those affected.

Dr. Camel's Conclusion

While desferrioxamine has been a valuable tool in managing iron overload in thalassaemia, the search for better treatments continues. This study sheds light on the ongoing challenges of iron chelation therapy and highlights the need for more effective and patient-friendly options. It's a reminder that the journey through the desert of thalassaemia is long and requires a collaborative effort to find the best possible solutions.

Date :
  1. Date Completed 2014-02-06
  2. Date Revised 2022-11-18
Further Info :

Pubmed ID

23963793

DOI: Digital Object Identifier

10.1002/14651858.CD004450.pub3

Related Literature

SNS
PICO Info
in preparation
Languages

English

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