Effective treatment of iron: A Synthesis of Findings from 40 Studies

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Original Abstract of the Article

Major research findings

Iron deficiency is a common condition, especially in women of childbearing age. 12 While iron supplements are widely used, they can cause gastrointestinal side effects. 24 Several studies have investigated different approaches to enhance iron absorption and reduce side effects, including dietary interventions, iron-fortified foods, and iron chelation therapy. 12 , 38 , 30 , 7 , 8 , 35 , 15 , 39 , 29 , 34 , 36 , 33 , 14 , 17 , 19 , 25 , 24 , 37 , 2 , 9 , 21 , 10 , 20 , 27 , 23 , 28 , 1 , 32 , 31 , 5 , 18 , 6 , 13 , 3 , 16 , 4 , 40 , 22 , 11 .

treatment Summary

Common treatments for iron deficiency include oral iron supplements, iron injections, blood transfusions, and erythropoietin. 6 Oral iron supplements are effective for treating iron deficiency, but they can cause gastrointestinal side effects. 24 Iron injections, blood transfusions, and erythropoietin are often considered when oral iron is not tolerated or when a rapid increase in iron levels is required. 6

Researchers are exploring various approaches to improve iron absorption and minimize side effects. 12 , 38 , 30 , 7 , 8 , 35 , 15 , 39 , 29 , 34 , 36 , 33 , 14 , 17 , 19 , 25 , 24 , 37 , 2 , 9 , 21 , 10 , 20 , 27 , 23 , 28 , 1 , 32 , 31 , 5 , 18 , 6 , 13 , 3 , 16 , 4 , 40 , 22 , 11 .

Benefits and Risks

Benefits Summary

Iron deficiency can be effectively treated with various methods including oral iron supplements, iron injections, blood transfusions, and erythropoietin. 6 Oral iron supplements are an effective option, but they can cause gastrointestinal side effects. 24 Iron injections, blood transfusions, and erythropoietin are often used when oral iron is not tolerated or when a rapid increase in iron levels is needed. 6

Risks Summary

Oral iron supplements are often associated with gastrointestinal side effects, such as nausea, vomiting, and constipation. 24 While iron injections can offer a faster absorption rate and potentially fewer side effects than oral iron, they may be more expensive. 32 , 34 .

Comparison of Studies

Commonalities in Research

Many studies have shown the efficacy of oral iron supplements in treating iron deficiency anemia. 6 , 24 However, these supplements often lead to gastrointestinal side effects. 24 Therefore, other treatment options like injections and blood transfusions may be necessary in cases of poor tolerance or urgent need for iron replacement. 6

Differences in Research

Research has explored various methods to enhance iron absorption and minimize side effects, including using dietary interventions, iron-fortified foods, and iron chelation therapy. 12 , 38 , 30 , 7 , 8 , 35 , 15 , 39 , 29 , 34 , 36 , 33 , 14 , 17 , 19 , 25 , 24 , 37 , 2 , 9 , 21 , 10 , 20 , 27 , 23 , 28 , 1 , 32 , 31 , 5 , 18 , 6 , 13 , 3 , 16 , 4 , 40 , 22 , 11 .

Consistency and Contradictions in Results

Most studies indicate that oral iron supplements are effective in treating iron deficiency anemia. 6 , 24 However, these supplements often lead to gastrointestinal side effects. 24 Therefore, alternative treatments like injections and blood transfusions may be necessary for those who cannot tolerate oral iron or require rapid iron replacement. 6

Implications for Real-Life Application

Iron deficiency anemia can be effectively managed with various treatments, including oral iron supplements, iron injections, blood transfusions, and erythropoietin. 6 While oral iron supplements are effective, they can cause gastrointestinal side effects. 24 In cases of poor tolerance or a need for rapid iron replenishment, iron injections, blood transfusions, and erythropoietin may be considered. 6

Limitations of Current Research

While extensive research has been conducted on iron deficiency anemia treatments, there are still gaps in our understanding. 6 For instance, long-term safety and effectiveness data for iron injections and blood transfusions are limited. 32 Additionally, the optimal treatment approach can vary depending on factors like the patient's age, symptoms, and lifestyle. 34 Therefore, consulting a doctor is crucial to determine the most suitable iron deficiency treatment plan. 36 .

Future Research Directions

Further research is needed to comprehensively understand the various aspects of iron deficiency anemia treatments. 6 Long-term safety and effectiveness data for iron injections and blood transfusions should be a priority area of focus. 32 Additionally, personalized treatment approaches based on patient characteristics like age, symptoms, and lifestyle are essential to ensure optimal outcomes. 34 Consultations with a healthcare professional are vital to determine the best treatment plan for each individual. 36 .

Conclusion

Iron deficiency anemia can be effectively treated with various methods including oral iron supplements, iron injections, blood transfusions, and erythropoietin. 6 While oral iron supplements are an effective option, they can cause gastrointestinal side effects. 24 Iron injections, blood transfusions, and erythropoietin are often considered when oral iron is not tolerated or when a rapid increase in iron levels is required. 6 The best treatment plan depends on the individual patient's needs and circumstances. 34 It's crucial to consult a healthcare professional to determine the most appropriate treatment for iron deficiency. 36 .

treatment List

Oral iron supplements, iron injections, blood transfusions, erythropoietin, dietary interventions, iron-fortified foods, iron chelation therapy.

Keywords
Benefit Keywords
Iron deficiency anemia improvement
1
Ferritin efficacy
Iron therapy
2
Erythrocyte increment
Hemoglobin increment
Serum iron increment
3
Increased hemoglobin
Increased serum iron
5
Oral iron benefit
6
Haematological response
Reduced side effects
7
Iron status improvement
8
Safe and rapid reversal of iron-deficiency anemia
9
Iron chelation for malaria
10
Iron chelation
11
Improved iron deficiency treatment
12
Safe for pregnant women
13
Reduced iron overload
14
Iron deficiency treatment
15
Oral iron chelation
16
Iron overload treatment
17
Improved IDA treatment
19
Improved iron deficiency treatment
20
Iron chelation therapy
21
Deferasirox for MDS
22
Improved iron status
23
Increased ferritin
Increased haemoglobin
Reduced adverse events
25
Improved iron status
26
Anemia treatment
27
Hematologic recovery
Improved iron incorporation
28
Iron deficiency anemia prevention
29
Improved IDA treatment
30
IDA treatment
31
Iron deficiency treatment
32
Iron-deficiency anemia treatment
Well tolerated
33
Improved haemoglobin
Improved serum ferritin
34
Cost-effective
Improved hematological parameters
Improved hemoglobin
35
Treatment for IDA in pregnant women
36
Corrected IDA
37
Iron absorption enhancement
38
Ferritin increase
Hematocrit increase
Hemoglobin increase
Iron increase
39
Risk Keywords
Side effects
1
Side-effects
Siderosis of internal organs
3
Iron supplement side effects
4
Less effective than ferrous sulfate
5
IV thrombosis risk
Insufficient evidence
6
Serious side effects with previous iron preparations
9
Iron deficiency
12
Creatinine increase
Gastrointestinal symptoms
Skin rash
14
Increased morbidity
Increased mortality
Poor adherence
Reduced quality of life
16
Impaired immune response
18
Adherence challenge
Iron overload
21
GI side effects
24
Inflammation
26
Poorer iron status
28
IDA treatment
31
Gastrointestinal side effects
Local pain
34
Gastrointestinal complaints
35
Gastrointestinal intolerance
36
Hypophosphataemia
37
Literature analysis of 40 papers
Positive Content
36
Neutral Content
1
Negative Content
3
Article Type
29
7
11
7
39
1.

Comparison trial of iron succinylprotein complex or iron gluconate complex in the treatment of iron deficiency anemia.

Author: PedrazzoliP, ScottiA, FarinaD

Iron deficiency anemia improvement
Side effects

This study compared the effectiveness of two iron supplements, iron succinylprotein complex and iron gluconate complex, in treating 40 patients with iron deficiency anemia. Both supplements improved blood values, but iron succinylprotein complex was more effective in some areas. Iron succinylprotein complex was better tolerated, with side effects reported in only 2 out of 20 patients, compared to 10 out of 20 patients taking iron gluconate complex. The study suggests that iron succinylprotein complex may be a preferable treatment option for iron deficiency anemia due to its better effectiveness and fewer side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Ferritin versus ferrous sulphate preparations: a controlled study in sideropaenic patients.

Author: SásG, SchefferK, SchreiberG, BräuerH, CeccarelliG

Ferritin efficacy
Iron therapy

This study compared the effectiveness of two different iron supplements: ferrous sulfate (bivalent iron) and ferritin (trivalent iron) in 54 patients who needed iron treatment. Both forms of iron improved blood values, but the improvement was more consistent and progressive with the ferritin preparations. The study concludes that ferritin is an effective treatment option for iron deficiency, likely due to its more natural and physiological form of iron.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

[Are any drug admixtures except iron preparations required in the treatment of iron deficiency anemia?].

Author: Mandel'baumA Ia

Erythrocyte increment
Hemoglobin increment
Serum iron increment
Side-effects
Siderosis of internal organs

A study of 250 women with iron deficiency anemia found that adding vitamins B12, B6, copper sulfate, or a combination of B vitamins and copper sulfate to iron therapy did not significantly improve hemoglobin, red blood cell count, or serum iron levels compared to iron treatment alone. While iron injections showed slightly faster hemoglobin increases, the study concluded that combining iron with other preparations is not necessary and may increase the risk of side effects and iron overload. Iron injections are recommended only in cases of impaired iron absorption.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

4.

Iron supplementation for acute blood loss anemia after coronary artery bypass surgery: a randomized, placebo-controlled study.

Author: CrosbyL, PalarskiV A, CottingtonE, CmolikB

Iron supplement side effects

Oral iron supplements did not assist in restoring red blood cell mass or help maintain total body iron stores after uncomplicated coronary artery bypass surgery.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Are ferric compounds useful in treatment of iron deficiency anemia?

Author: ArvasA, GürE

Increased hemoglobin
Increased serum iron
Less effective than ferrous sulfate

Iron deficiency anemia is a common condition, and while iron supplements are often used to treat it, there's uncertainty about the effectiveness of different iron compounds. This study compared two iron supplements, ferric polymaltose and ferrous sulfate, in infants with iron deficiency anemia. The study found that ferrous sulfate was more effective in improving blood levels of iron and red blood cells than ferric polymaltose.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Treatments for iron deficiency anaemia in pregnancy.

Author: CuervoL G, MahomedK

Oral iron benefit
IV thrombosis risk
Insufficient evidence

There is inconclusive evidence regarding the effects of treating iron deficiency anemia in pregnancy due to a lack of good quality trials. Oral iron treatment showed a reduction in women with low hemoglobin and a greater mean hemoglobin level compared to placebo, but no data were available on clinically relevant outcomes. Intravenous iron treatment was associated with an increased risk of venous thrombosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

7.

Evaluation of efficacy and safety of iron polymaltose complex and folic acid (Mumfer) vs iron formulation (ferrous fumarate) in female patients with anaemia.

Author: ReddyP S, AdsulB B, GandewarK, KordeK M, DesaiA

Haematological response
Reduced side effects

Iron polymaltose complex (IPC) was found to be more effective and better tolerated than oral ferrous fumarate in treating iron deficiency anemia in women.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Dietary treatment of iron deficiency in women of childbearing age.

Author: PattersonA J, BrownW J, RobertsD C, SeldonM R

Iron status improvement

A high-iron diet produced smaller increases in SF than did iron supplementation but resulted in continued improvements in iron status during a 6-mo follow-up in iron-deficient women of childbearing age.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Iron deficiency and anaemia in pregnancy: modern aspects of diagnosis and therapy.

Author: BreymannChristian

Safe and rapid reversal of iron-deficiency anemia
Serious side effects with previous iron preparations

Iron deficiency anemia is common, especially during pregnancy. Accurate diagnosis requires more than just checking hemoglobin levels. Other tests, including ferritin, transferrin saturation, and red blood cell characteristics, are needed, particularly before giving iron injections. Ferritin can be misleading in the presence of inflammation, so other tests may be needed. Iron injections have caused serious side effects in the past, but newer types of iron injections are safer and effective. Data from over 8 years and 25 countries suggest that iron sucrose complex therapy is a safe and effective treatment for iron deficiency anemia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Iron chelating agents for treating malaria.

Author: SmithH J, MeremikwuM

Iron chelation for malaria

This study examines the effects of iron chelators in improving patient outcomes in malaria, exploring the potential of iron chelation as an adjunctive therapy to standard antimalarial regimens.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload.

Author: PigaAntonio, GalanelloRenzo, ForniGian Luca, CappelliniMaria Domenica, OrigaRaffaella, ZappuAntonietta, DonatoGuido, BordoneElena, LavagettoAntonella, ZanaboniLaura, SechaudRomain, HewsonNicola, FordJohn M, OpitzHerbert, AlbertiDaniele

Iron chelation

This phase II study compared deferasirox, an oral iron chelator, to deferoxamine (DFO), a parenteral chelator, in treating adults with transfusional hemosiderosis, highlighting the potential advantages of oral chelation therapy.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Effect of high-dose iron supplements on fractional zinc absorption and status in pregnant women.

Author: HarveyLinda J, DaintyJack R, HollandsWendy J, BullVictoria J, HoogewerffJurian A, FoxallRobert J, McAnenaLiadhan, StrainJ J, Fairweather-TaitSusan J

Safe for pregnant women

Iron supplementation during pregnancy did not adversely affect zinc metabolism in iron-replete pregnant women. Zinc absorption increased during late pregnancy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Deferasirox for the treatment of chronic iron overload in transfusional hemosiderosis.

Author: ShashatyGeorge, FrankewichRaymond, ChakrabortiTamal, ChoudaryJasti, Al-FayoumiSuliman, KacubaAlice, CastilloSonia, Robie-SuhKathy, RievesDwaine, WeissKaren, PazdurRichard

Reduced iron overload
Creatinine increase
Gastrointestinal symptoms
Skin rash

This report describes the Food and Drug Administration's review of data and analyses leading to the approval of the oral iron chelator, deferasirox for the treatment of chronic iron overload due to transfusional hemosiderosis. The FDA granted deferasirox accelerated approval on November 2, 2005, for use in treating chronic iron overload due to transfusional hemosiderosis in patients > or =2 years of age. The sponsor must obtain clinical data demonstrating the drug's long-term safety and effectiveness.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

15.

Electrolytic iron or ferrous sulfate increase body iron in women with moderate to low iron stores.

Author: SwainJames H, JohnsonLuAnn K, HuntJanet R

Iron deficiency treatment

This study compared the efficacy of different iron supplements in improving iron status in women with moderate to low iron stores, finding that ferrous sulfate (FeSO4) and electrolytic iron were more effective than reduced or heme iron.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

16.

Prospective evaluation of patient-reported outcomes during treatment with deferasirox or deferoxamine for iron overload in patients with beta-thalassemia.

Author: CappelliniMaria Domenica, BejaouiMohamed, AgaogluLeyla, PorterJohn, CoatesThomas, JengMichael, LaiMaria Eliana, MangiagliAntonio, StraussGabriele, GirotRobert, WatmanNora, FersterAlina, LoggettoSandra, AbishSharon, CarioHolger, ZoumbosNicolaos, VichinskyElliott, OpitzHerbert, Ressayre-DjafferCatherine, AbetzLinda, RofailDiana, BaladiJean-Francois

Oral iron chelation
Increased morbidity
Increased mortality
Poor adherence
Reduced quality of life

Deferasirox, an orally administered iron chelator, is an alternative to deferoxamine (DFO) for treating iron overload in patients with transfusion-dependent disorders.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Relative bioavailability of deferasirox tablets administered without dispersion and dispersed in various drinks.

Author: SéchaudR, DutreixC, BalezS, PommierF, DumortierT, MorissonS, BrunE

Iron overload treatment

Deferasirox tablets were evaluated for their suitability when dispersed in flavored drinks, as an alternative to water, for patients with iron overload.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Impact of iron treatment on immune effector function and cellular iron status of circulating monocytes in dialysis patients.

Author: SonnweberThomas, TheurlIgor, SeifertMarkus, SchrollAndrea, EderSusanne, MayerGert, WeissGünter

Impaired immune response

Intravenous iron injection led to short-term activation of the nuclear factor kappa-B pathway in monocytes, while increased circulating ferritin levels were associated with impaired immune response.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Efficacy and tolerability of a prolonged release ferrous sulphate formulation in iron deficiency anaemia: a non-inferiority controlled trial.

Author: ZaimMohammed, PiselliLeonardo, FioravantiPino, Kanony-TrucClaire

Improved IDA treatment

Iron deficiency anemia (IDA) occurs when the body doesn't have enough iron. It's more common in women due to iron loss from menstruation. Oral iron supplements are effective, but can cause stomach upset, which might make it harder for people to take them.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Heme iron-based dietary intervention for improvement of iron status in young women.

Author: HoppeMichael, BrünBeatrice, LarssonMaria Pia, MoraeusLotta, HulthénLena

Improved iron deficiency treatment

This study investigates the use of heme iron, a form of iron with high bioavailability, in a diet-based treatment program to improve iron status in women of reproductive age.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Desferrioxamine mesylate for managing transfusional iron overload in people with transfusion-dependent thalassaemia.

Author: FisherSheila A, BrunskillSusan J, DoreeCarolyn, GoodingSarah, ChowdhuryOnima, RobertsDavid J

Iron chelation therapy
Adherence challenge
Iron overload

Thalassaemia major is a genetic disease requiring lifelong management with blood transfusions, leading to iron overload. This review explores the use of desferrioxamine, deferiprone, and deferasirox for iron chelation therapy. While desferrioxamine is a widely used chelator, adherence is challenging. The review discusses whether desferrioxamine, alone or in combination with oral chelators, is the most effective treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

Deferasirox for managing iron overload in people with myelodysplastic syndrome.

Author: MeerpohlJoerg J, SchellLisa K, RückerGerta, FleemanNigel, MotschallEdith, NiemeyerCharlotte M, BasslerDirk

Deferasirox for MDS

This review explores the use of deferasirox, a newer oral iron chelator, for treating secondary iron overload in patients with myelodysplastic syndrome (MDS). The study investigates whether deferasirox offers significant benefits compared to other treatment options.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

Effect of Intravenous Iron on Aerobic Capacity and Iron Metabolism in Elite Athletes.

Author: BurdenRichard J, PollockNoel, WhyteGregory P, RichardsToby, MooreBrian, BusbridgeMark, SraiSurjit K, OttoJames, PedlarCharles R

Improved iron status

A single intravenous iron injection was effective in improving iron status in iron-deficient nonanemic endurance athletes for at least 4 weeks. However, the injection did not lead to improved aerobic capacity. The study suggests that iron availability may supersede inflammation in the regulation of hepcidin after acute intravascular iron injection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: a systematic review and meta-analysis.

Author: TolkienZoe, StecherLynne, ManderAdrian P, PereiraDora I A, PowellJonathan J

GI side effects

Ferrous sulfate is associated with a significant increase in gastrointestinal-specific side-effects but does not find a relationship with dose.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

Intravenous Iron Sucrose versus Oral Iron in the Treatment of Pregnancy with Iron Deficiency Anaemia: A Systematic Review.

Author: ShiQingquan, LengWenying, WazirRomel, LiJinhong, YaoQiang, MiChen, YangJing, XingAiyun

Increased ferritin
Increased haemoglobin
Reduced adverse events

Intravenous iron sucrose was more effective than oral iron therapy for iron deficiency anemia (IDA) during pregnancy, with significant increases in hemoglobin and ferritin levels and fewer adverse events. There was no significant difference in birth weight between the two groups.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

Comparison of iron status 28 d after provision of antimalarial treatment with iron therapy compared with antimalarial treatment alone in Ugandan children with severe malaria.

Author: CusickSarah E, OpokaRobert O, SsemataAndrew S, GeorgieffMichael K, JohnChandy C

Improved iron status
Inflammation

The withholding of iron from children with severe malaria is associated with lower ferritin and hepcidin at day 28 but not a lower hemoglobin concentration.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

27.

Systematic review and meta-analysis of iron therapy in anaemic adults without chronic kidney disease: updated and abridged Cochrane review.

Author: ClevengerBen, GurusamyKurinchi, KleinAndrew A, MurphyGavin J, AnkerStefan D, RichardsToby

Anemia treatment

This systematic review and meta-analysis assessed the efficacy and safety of iron therapies for the treatment of anemia in adults with cardiac disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

28.

Delaying Iron Therapy until 28 Days after Antimalarial Treatment Is Associated with Greater Iron Incorporation and Equivalent Hematologic Recovery after 56 Days in Children: A Randomized Controlled Trial.

Author: CusickSarah E, OpokaRobert O, AbramsSteven A, JohnChandy C, GeorgieffMichael K, MupereEzekiel

Hematologic recovery
Improved iron incorporation
Poorer iron status

Delaying iron supplementation for 28 days in children with malaria and anemia improved iron incorporation but did not lead to better hematologic recovery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

29.

Iron Pots for the Prevention and Treatment of Anemia in Preschoolers.

Author: ArcanjoFrancisco Plácido Nogueira, MacêdoDébora Rodrigues Ribeiro, SantosPaulo Roberto, ArcanjoCaio Plácido Costa

Iron deficiency anemia prevention

The study found that using iron cooking pots in developing countries could provide an innovative strategy to prevent and treat iron deficiency anemia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

30.

Iron Bisglycinate Chelate and Polymaltose Iron for the Treatment of Iron Deficiency Anemia: A Pilot Randomized Trial.

Author: NameJosé João, VasconcelosAñdrea Rodrigues, Valzachi Rocha MalufMaria Cristina

Improved IDA treatment

Iron Bisglycinate Chelate (FeBC) and polymaltose iron (FeP) are used to treat Iron Deficiency Anemia (IDA), with good tolerability and low adverse effects. This study investigates the differences in their structures and bioavailability.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

31.

A systematic literature review and indirect comparison of iron isomaltoside and ferric carboxymaltose in iron deficiency anemia after failure or intolerance of oral iron treatment.

Author: PollockRichard F, MudumaGorden

IDA treatment
IDA treatment

This study compared the efficacy of two IV iron formulations in patients with iron deficiency anemia (IDA): iron isomaltoside (IIM) and ferric carboxymaltose (FCM).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

32.

Intravenous iron therapy for non-anaemic, iron-deficient adults.

Author: MilesLachlan F, LittonEdward, ImbergerGeorgina, StoryDavid

Iron deficiency treatment

Iron deficiency is a common problem that can cause fatigue and weakness. While oral iron supplements are often used, they can cause side effects and aren't effective for all types of iron deficiency. Intravenous iron, particularly newer formulations, is being used more frequently for iron deficiency, as it has fewer side effects and can be used for a wider range of patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

33.

Long-Term Effectiveness of Oral Ferric Maltol vs Intravenous Ferric Carboxymaltose for the Treatment of Iron-Deficiency Anemia in Patients With Inflammatory Bowel Disease: A Randomized Controlled Noninferiority Trial.

Author: HowaldtStefanie, DomènechEugeni, MartinezNicholas, SchmidtCarsten, BokemeyerBernd

Iron-deficiency anemia treatment
Well tolerated

Ferric maltol achieved clinically relevant increases in hemoglobin but did not show noninferiority to ferric carboxymaltose at week 12. Both treatments had comparable long-term effectiveness and were well tolerated.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

34.

Iron preparations for women of reproductive age with iron deficiency anaemia in pregnancy (FRIDA): a systematic review and network meta-analysis.

Author: RogozińskaEwelina, DaruJahnavi, NicolaidesMarios, Amezcua-PrietoCarmen, RobinsonSusan, WangRui, GodolphinPeter J, SaboridoCarlos Martín, ZamoraJavier, KhanKhalid S, ThangaratinamShakila

Improved haemoglobin
Improved serum ferritin
Gastrointestinal side effects
Local pain

Intravenous iron sucrose was more effective than oral ferrous sulfate in treating iron deficiency anemia during pregnancy. A network meta-analysis of 53 randomized trials showed that intravenous iron sucrose improved both hemoglobin and serum ferritin levels compared to oral ferrous sulfate. Intravenous ferric carboxymaltose also showed some evidence of benefit.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

37.

Hypophosphataemia following ferric derisomaltose and ferric carboxymaltose in patients with iron deficiency anaemia due to inflammatory bowel disease (PHOSPHARE-IBD): a randomised clinical trial.

Author: ZollerHeinz, WolfMyles, BlumensteinIrina, PrimasChristian, LindgrenStefan, ThomsenLars L, ReinischWalter, IqbalTariq

Corrected IDA
Hypophosphataemia

This randomized, double-blind, clinical trial compared the incidence of hypophosphataemia after treatment with ferric carboxymaltose (FCM) or ferric derisomaltose (FDI) in patients with IBD and iron deficiency anaemia (IDA). It finds that despite comparably effective treatment of IDA, FCM caused a significantly higher rate of hypophosphataemia than FDI.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

38.

Iron oxide nanoparticles carried by probiotics for iron absorption: a systematic review.

Author: CiontCălina, MesaroșAmalia, PopOana Lelia, VodnarDan Cristian

Iron absorption enhancement

This research investigates the interaction of iron oxide nanoparticles (IONPs) with probiotic cells and its impact on iron absorption, bioavailability, and microbiota variation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

39.

Intravenous infusions of ferumoxytol compared to oral ferrous sulfate for the treatment of anemia in pregnancy: a randomized controlled trial.

Author: AwomoloAdeola M, McWhirterAmanda, SadlerLynn C, CoppolaLynn M, HillMeghan G

Ferritin increase
Hematocrit increase
Hemoglobin increase
Iron increase

Intravenous ferumoxytol was more effective than oral ferrous sulfate in treating iron-deficiency anemia in pregnancy, leading to significant increases in maternal hemoglobin, hematocrit, iron, and ferritin. Neonates of mothers who received intravenous ferumoxytol had higher ferritin concentrations in cord blood, at the same gestation and birthweight.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

40.

Baseline characteristics of patients in the randomized study to investigate the efficacy and safety of ferric carboxymaltose as treatment for heart failure with iron deficiency: HEART-FID trial.

Author: HarringtonJosephine, MentzRobert J, RockholdFrank W, GargJyotsna, ButlerJaved, De PasqualeCarmine G, EzekowitzJustin A, LewisGregory D, O'MearaEileen, PonikowskiPiotr, TroughtonRichard W, WongYee Weng, AdamczykRobert, BlackmanNicole, HernandezAdrian F

The HEART-FID study, investigating intravenous iron in patients with heart failure (HF) and iron deficiency, has enrolled a large and diverse cohort. Participants had similar baseline demographics and clinical characteristics to those in other contemporary HF with reduced ejection fraction (HFrEF) trials.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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