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Combined inhaled anticholinergics and short-acting beta2-agonists for initial treatment of acute asthma in children.

Author: DucharmeFrancine M, GriffithsBenedict

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

When asthma symptoms worsen suddenly and don't improve with usual treatment, children are typically given inhaled medications that quickly open airways (short-acting beta2-agonists, SABAs). Anticholinergics, another type of inhaler, have a slower effect but might help reduce airway narrowing and mucus. Combining anticholinergics with SABAs could potentially improve and prolong the opening of airways.
Paper Details　
Original Abstract of the Article :
There are several treatment options for managing acute asthma exacerbations (sustained worsening of symptoms that do not subside with regular treatment and require a change in management). Guidelines advocate the use of inhaled short acting beta2-agonists (SABAs) in children experiencing an asthma e...See full text at original site
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引用元：
https://doi.org/10.1002/14651858.CD000060.pub2

データ提供：米国国立医学図書館（NLM）

Combined Anticholinergics and Beta2-Agonists: A Breath of Fresh Air for Childhood Asthma

Asthma, a chronic respiratory disease, can cause significant challenges for children. This study explores the potential benefits of combining inhaled anticholinergics, such as ipratropium bromide, with short-acting beta2-agonists (SABAs) for initial treatment of acute asthma exacerbations in children. The researchers reviewed existing guidelines and explored the rationale behind this combination, highlighting the potential for enhanced and prolonged bronchodilation. This combination could offer a more effective treatment strategy for acute asthma episodes in children, improving their quality of life and reducing the impact of these exacerbations.

A New Approach to Breathe Easier: Combining Therapies for Childhood Asthma

This study suggests that combining anticholinergics with SABAs could offer a more effective approach to treating acute asthma exacerbations in children. The researchers cite the potential for synergistic effects, with anticholinergics addressing cholinergic bronchomotor tone and SABAs providing bronchodilation. This could potentially improve the effectiveness of asthma treatment, allowing children to breathe easier and live more fulfilling lives.

A Breath of Hope for Children with Asthma

This research provides a promising avenue for improving the management of acute asthma exacerbations in children. By combining inhaled anticholinergics with SABAs, healthcare providers could potentially achieve more effective and prolonged bronchodilation, reducing the frequency and severity of asthma episodes. This could lead to a better quality of life for children with asthma, allowing them to enjoy a more active and fulfilling childhood.

Dr.Camel's Conclusion

This study suggests a potential improvement in asthma management for children. Combining anticholinergics with SABAs could lead to more effective and prolonged bronchodilation, potentially reducing the frequency and severity of asthma episodes. This could provide children with asthma a better quality of life, allowing them to breathe easier and live more fulfilling lives.

Date :
  1. Date Completed 2014-02-06
  2. Date Revised 2018-12-21
Further Info :

Pubmed ID

23966133

DOI: Digital Object Identifier

10.1002/14651858.CD000060.pub2

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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