Paper Details
- Home
- Paper Details
Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase.
Author: BochmanMatthew L, BrodskyJeffrey L, SchwachaAnthony, SeguinSandlin, SeibelWilliam L, SimonNicholas
Original Abstract of the Article :
Most currently available small molecule inhibitors of DNA replication lack enzymatic specificity, resulting in deleterious side effects during use in cancer chemotherapy and limited experimental usefulness as mechanistic tools to study DNA replication. Towards development of targeted replication inh...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791872/
データ提供:米国国立医学図書館(NLM)
Ciprofloxacin: A New Target for Inhibiting DNA Replication
The search for [targeted inhibitors of DNA replication] is a critical area of research in the fight against [cancer]. This study investigates the potential of [ciprofloxacin], a well-known antibiotic, as an inhibitor of the [Mcm2-7 replicative helicase]. The researchers found that [ciprofloxacin] preferentially inhibits [Mcm2-7] at concentrations that have minimal effects on other helicases. This discovery opens up new avenues for the development of [specific inhibitors of Mcm2-7], potentially leading to more effective and targeted cancer therapies.
Ciprofloxacin's Unexpected Role in Cancer Treatment
The study's findings suggest that [ciprofloxacin] may have a dual role as both an [antibiotic] and a [potential anticancer agent]. The researchers' discovery that [ciprofloxacin] specifically targets [Mcm2-7] is a significant advancement in the field of [cancer research]. This finding provides a promising starting point for developing new [quinolone-based inhibitors] that specifically target [Mcm2-7].
The Future of Targeted Cancer Therapies
This research highlights the importance of [exploring novel drug targets] in the development of [effective cancer therapies]. The discovery that [ciprofloxacin] can inhibit [Mcm2-7] opens up exciting possibilities for developing new [targeted therapies] that can effectively combat cancer without the side effects associated with non-specific inhibitors. Continued research in this area is essential for bringing these promising new treatments to patients.
Dr.Camel's Conclusion
Just like a camel's ability to navigate harsh terrain, [ciprofloxacin] can navigate the complex pathways of DNA replication to effectively target its intended target. This research showcases the potential for repurposing existing drugs for new therapeutic applications.
Date :
- Date Completed 2014-09-03
- Date Revised 2021-10-21
Further Info :
Related Literature
English
This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.