Side Effects of ofloxacin: A Synthesis of Findings from 24 Studies

  1. Home
  2. Side Effects of ofloxacin
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of ofloxacin: A Synthesis of Findings from 24 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of ofloxacin: A Synthesis of Findings from 24 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Main Research Findings

Ofloxacin is a widely used antibiotic to treat bacterial infections. While many studies have confirmed the efficacy of ofloxacin, various side effects have also been reported. 15 showed that treatment regimens including ofloxacin were effective in treating Helicobacter pylori infections. 23 showed that treatment regimens including ofloxacin were effective in treating Helicobacter pylori infections. In addition, 7 showed that treatment regimens including ofloxacin were effective in treating various infections.

Reasons for Side Effects

Side effects of ofloxacin are thought to be related to the drug's mechanism of action. Ofloxacin exerts its antibacterial effect by inhibiting bacterial DNA replication. However, this mechanism of action can also affect human cells, potentially causing side effects. 13 showed that ofloxacin binds to DNA and inhibits cell proliferation.

Common Side Effects

Gastrointestinal

Ofloxacin can cause gastrointestinal side effects. The most common side effects are nausea, vomiting, and diarrhea. These side effects are usually mild and disappear after stopping the medication. 1 reported that many of the 12 healthy volunteers who took ofloxacin experienced gastrointestinal side effects.

Nervous System

Ofloxacin can cause nervous system side effects. The most common side effects are headache, dizziness, and lightheadedness. These side effects are usually mild and disappear after stopping the medication. However, serious side effects can occur rarely. 2 reported cases where ofloxacin caused psychological side effects leading to serious mental symptoms.

Skin

Ofloxacin can cause skin side effects. The most common side effects are rash, itching, and photosensitivity. These side effects are usually mild and disappear after stopping the medication. However, serious side effects can occur rarely. 5 reported a case where a patient taking ofloxacin developed purpura on their skin after exposure to sunlight.

Musculoskeletal

Ofloxacin can cause musculoskeletal side effects such as joint pain (arthralgia), tendonitis, and muscle pain (myalgia). 8 reported cases of disabling and potentially permanent musculoskeletal disorders associated with ofloxacin use.

Countermeasures for Side Effects

Gastrointestinal

To reduce gastrointestinal side effects, it is recommended to take ofloxacin with food. It is also important to stay hydrated. Consult your doctor if the side effects are severe.

Nervous System

To reduce nervous system side effects, it is recommended to avoid driving or operating dangerous machinery while taking ofloxacin. It is also important to avoid alcohol consumption. Consult your doctor if the side effects are severe.

Skin

To reduce skin side effects, it is recommended to avoid sun exposure while taking ofloxacin. It is also helpful to apply sunscreen. Consult your doctor if the side effects are severe.

Musculoskeletal

If you experience musculoskeletal pain, stop taking ofloxacin and consult your doctor. Corticosteroids may be used to treat tendon-related side effects. 8

Comparison of Studies

Common Points

Many studies have shown that ofloxacin is effective in treating bacterial infections. However, various side effects have also been reported. These studies have shown that ofloxacin can cause various side effects.

Differences

These studies have shown that the types and severity of ofloxacin's side effects vary depending on the study. In addition, the background and method of administration of patients taking ofloxacin can also affect side effects.

Note on Application to Real Life

Ofloxacin is effective in treating various bacterial infections, but it also carries the risk of side effects. When taking ofloxacin, it is important to understand the risks and benefits, and discuss them with your doctor. In particular, consult your doctor if you have experienced side effects from ofloxacin in the past. Always follow your doctor's instructions carefully and report any unusual symptoms or side effects.

Limitations of Current Research

Research on the side effects of ofloxacin is still insufficient. Further research is needed.

Future Research Directions

Future research is needed to reduce the side effects of ofloxacin. For example, research on whether combining ofloxacin with other drugs can reduce side effects is promising.

Conclusion

Ofloxacin is a drug effective in treating bacterial infections, but it can cause various side effects. When taking ofloxacin, it is important to understand the risks and benefits, and discuss them with your doctor. It is hoped that further research will lead to the development of methods to reduce the side effects of ofloxacin. It's important to be aware of the potential side effects and to discuss any concerns you have with your doctor.

Literature analysis of 24 papers
Positive Content
16
Neutral Content
2
Negative Content
6
Article Type
4
1
2
2
24
1.

Safety of multiple doses of ofloxacin in healthy volunteers.

Author: SteinG E, FlorS C, BealsB S

Safe antibiotic
Gastrointestinal upset
Headache
Liver dysfunction

Ofloxacin, a new fluoroquinolone antibiotic, was found to be safe and have a low potential for toxicity in a study of 12 healthy male volunteers. The most frequent side effects were gastrointestinal complaints, such as nausea, diarrhea, and upset.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Psychiatric side effects of ofloxacin used in the treatment of pelvic inflammatory disease.

Author: HallC E, KeeganH, RogstadK E

Psychiatric side effects
Psychotic reaction

Ofloxacin, a commonly used antibiotic, can cause serious psychiatric side effects, particularly in individuals with a history of mental illness. This abstract highlights two cases of ofloxacin-induced psychiatric reactions, emphasizing the importance of thorough medical history before prescribing the drug.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Comparative study of the effects of gentamicin, neomycin, streptomycin and ofloxacin antibiotics on sperm parameters and testis apoptosis in rats.

Author: KhakiArash, NovinMarefat Ghaffari, KhakiAmir Afshin, NouriMohammad, SanatiEhsan, NikmaneshMahdad

Fewer side effects
Sperm decrease
Testis apoptosis

This study compared the effects of aminoglycosides (gentamicin, neomycin, streptomycin) and fluoroquinolones (ofloxacin) on testis apoptosis and sperm parameters in rats. All drugs negatively affected sperm parameters and increased testis apoptosis, with streptomycin having the least detrimental effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase.

Author: SimonNicholas, BochmanMatthew L, SeguinSandlin, BrodskyJeffrey L, SeibelWilliam L, SchwachaAnthony

DNA replication inhibition
Side effects

This study investigated the potential of ciprofloxacin, a fluoroquinolone antibiotic, as a specific inhibitor of Mcm2-7, a key component of eukaryotic DNA replication. Ciprofloxacin was found to inhibit Mcm2-7 helicase activity and prevent cell proliferation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Photolocalized purpura during levofloxacin therapy.

Author: RubegniPietro, FeciLuca, PellegrinoMichele, FimianiMichele

Phototoxicity
Skin disorders

This case report describes a 75-year-old woman who developed a pruritic purpuric eruption on her lower extremities after being prescribed levofloxacin for hemorrhagic cystitis. The eruption occurred upon exposure to sunlight and differed from a classical sunburn. The authors suggest that purpuric eruptions on photoexposed skin should be considered another unusual side effect of levofloxacin.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Prioritizing human pharmaceuticals for ecological risks in the freshwater environment of Korea.

Author: JiKyunghee, HanEun Jeong, BackSunhyoung, ParkJeongim, RyuJisung, ChoiKyungho

Pharmaceutical residues

This study prioritizes human pharmaceuticals of potential ecological risk in the Korean water environment based on their amount of use, biological activity, and regional hydrologic characteristics. Acetaminophen, clarithromycin, ciprofloxacin, ofloxacin, metformin, and norethisterone were identified as high priority pharmaceuticals.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Fluoroquinolones: Blessings Or Curses.

Author: MajalekarPriyanka P, ShirotePramodkumar J

Antibacterial activity
Anaphylaxis
Phototoxicity
QT interval prolongation

Fluoroquinolones are a valuable class of antimicrobial agents that have been widely used for treating various infections. This review explores the development of fluoroquinolones from their discovery to the black box warning, highlighting their effectiveness and the challenges posed by increasing resistance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

A VigiBase descriptive study of fluoroquinolone induced disabling and potentially permanent musculoskeletal and connective tissue disorders.

Author: HurubaMadalina, FarcasAndreea, LeucutaDaniel Corneliu, BucsaCamelia, SiposMariana, MogosanCristina

Musculoskeletal disorders

Fluoroquinolones are a class of antibiotics that can cause serious musculoskeletal side effects, such as tendonitis and arthralgia. This study analyzed reports of FQ-associated disabling musculoskeletal disorders from VigiBase and found that levofloxacin and ciprofloxacin were the most commonly reported drugs associated with these side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Determination of ofloxacin in tear by HPLC-ESI-MS/MS method: comparison of ophthalmic drug release between a new mucoadhesive chitosan films and a conventional eye drop formulation in rabbit model.

Author: ByrroRicardo Martins Duarte, de Oliveira FulgêncioGustavo, da Silva CunhaArmando, CésarIsabela Costa, ChelliniPaula Rocha, PianettiGerson Antônio

Ocular infection treatment

A validated HPLC-ESI-MS/MS method was developed to quantify ofloxacin in rabbit tears. This method was used to assess the concentration of ofloxacin in tears after treatment with mucoadhesive chitosan films and conventional eye drops.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Adverse drug reaction monitoring during antimicrobial therapy for septicemia patients at a university hospital in New Delhi.

Author: AlamMuhammad Shamshir, PillaiKrishna Kolappa, AbdiSyed Aliul Hasan, KapurPrem, PillaiParu Kutty, NagarajanKandasamy

ADRs in septicemia
High ADRs in females
High ADRs in pediatrics

Adverse drug reactions (ADRs) were found in 26.5% of patients with septicemia who received antimicrobial therapy. More than half of these ADRs were moderate in severity and 66.7% were preventable.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

14.

Legionella: macrolides or quinolones?

Author: Pedro-BotetL, YuV L

Legionnaire's disease treatment
Drug interactions
Side effects
Therapeutic failures

Quinolones may be more effective than macrolides in treating Legionnaires' disease, based on in-vitro and animal studies. Observational studies also suggest that quinolones may lead to a faster recovery and fewer complications compared to macrolides. However, no randomized trials have compared the clinical efficacy of these drugs.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

15.

A community-based study of Helicobacter pylori therapy using the strategy of test, treat, retest, and re-treat initial treatment failures.

Author: LeeYi-Chia, WuHui-Min, ChenTony Hsiu-Hsi, LiuTzeng-Ying, ChiuHan-Mo, ChangChun-Chao, WangHsiu-Po, WuMing-Shiang, ChiangHung, WuMeng-Chen, LinJaw-Town

H. pylori eradication

A community-based test-treat-retest-re-treat strategy is being investigated for the eradication of Helicobacter pylori infection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

[Treatment of uncomplicated pelvic inflammatory disease: CNGOF and SPILF Pelvic Inflammatory Diseases Guidelines].

Author: VerdonR

Uncomplicated PID treatment
Antibiotic resistance
Ecological impact
Side effects

This review discusses treatment options for uncomplicated pelvic inflammatory disease, emphasizing the importance of antibiotic resistance and the need for broader antibiotic coverage to effectively treat the various causative agents.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Practice GuidelineGuidelines and recommendations for the diagnosis and treatment of specific medical conditions in medical practice.

Language : French

17.

[Efficacy of levofloxacin-based triple therapy as second-line Helicobacter pylori eradication].

Author: JungHae Sun, ShimKi-Nam, BaikSu Jung, NaYoun Ju, KangMin-Jung, JungJi Min, HaChang Yoon, JungSung-Ae, YooKwon

H. pylori eradication

Helicobacter pylori (H. pylori) is a bacteria that can cause stomach ulcers. This study compared the effectiveness of two treatments for H. pylori infection: levofloxacin-based triple therapy and bismuth-based quadruple therapy. The study found that levofloxacin-based triple therapy was more effective than bismuth-based quadruple therapy.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Korean

18.

A systematic review of preventive and therapeutic options for symptoms of cystitis in patients with bladder cancer receiving intravesical bacillus Calmette-Guérin immunotherapy.

Author: PoletajewSławomir, KrajewskiWojciech, AdamowiczJan, RadziszewskiPiotr

BCG immunotherapy
BCG side effects
Cystitis

BCG intravesical instillations for bladder cancer can cause cystitis. This review explored options for prevention and treatment, including BCG dose reduction, hyaluronic acid instillations, and oral antibiotics. However, more research is needed to determine their effectiveness and safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

19.

Levofloxacin- vs. ranitidine bismuth citrate-containing therapy after H. pylori treatment failure.

Author: GisbertJavier P, GisbertJose Luis, MarcosSantiago, Moreno-OteroRicardo, PajaresJose Maria

Alternative to quadruple therapy
Side effects

Both ranitidine bismuth citrate and levofloxacin-containing second-line regimens were effective in treating Helicobacter pylori infection after first-line eradication failure. Both regimens represent alternatives to quadruple therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Miliary pulmonary infection after BCG intravesical instillation: a rare, misdiagnosed and mistreated complication.

Author: CallerisGiorgio, MarraGiancarlo, CorcioneSilvia, OderdaMarco, CardellinoChiara, AudagnottoSabrina, FreaBruno, De RosaFrancesco Giuseppe, GonteroPaolo

bladder cancer treatment
BCG infection

This case report describes a patient who developed miliary pulmonary Bacillus Calmette-Guérin (BCG) infection after receiving intravesical BCG immunotherapy for non-muscle-invasive bladder cancer. The authors emphasize the importance of considering BCG infection in the differential diagnosis of pulmonary symptoms in patients receiving BCG therapy.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

Efficacy and tolerability of a third-line, levofloxacin-based, 10-day sequential therapy in curing resistant Helicobacter pylori infection.

Author: TursiAntonio, PicchioMarcello, EliseiWalter

H. pylori eradication
Side effects

A 10-day sequential triple therapy containing amoxicillin, levofloxacin and tetracycline was found to be effective and safe in curing resistant H. pylori infection in 67.23% of patients. 24.37% of patients experienced side effects, but only 1.68% withdrew from the study.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

22.

Efficacy of two levofloxacin-containing second-line therapies for Helicobacter pylori: a pilot study.

Author: CalhanTuran, KahramanResul, SahinAbdurrahman, SenatesEbubekir, DoganayHamdi Levent, KanatEvren, OzdilKamil, SokmenHacı Mehmet

H. pylori eradication

Levofloxacin-containing sequential therapy and levofloxacin-containing quadruple therapy regimens were effective for Helicobacter pylori eradication in patients who did not respond to standard triple therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Seven-day PPI-triple therapy with levofloxacin is very effective for Helicobacter pylori eradication.

Author: SchrauwenR W M, JanssenM J R, de BoerW A

H. pylori eradication

This study aims to evaluate the efficacy and tolerability of a one-week therapy using levofloxacin and esomeprazole for Helicobacter pylori eradication in a Dutch population.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

24.

Topical versus systemic antibiotics for chronic suppurative otitis media.

Author: ChongLee-Yee, HeadKaren, WebsterKatie E, DawJessica, RichmondPeter, SnellingTom, BhuttaMahmood F, SchilderAnne Gm, BurtonMartin J, Brennan-JonesChristopher G

CSOM treatment
CSOM
hearing loss

Chronic suppurative otitis media (CSOM) is a chronic ear infection that often involves multiple microorganisms. Antibiotics are the main treatment for CSOM, and can be administered topically or systemically.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.