The effect of Ginkgo biloba extracts on the pharmacokinetics and pharmacodynamics of cilostazol and its active metabolites in healthy Korean subjects.

Author: GhimJong-Lyul, KimDong-Hyun, KimEun-Young, KimGa-Young, KimHo-Sook, OhMinkyung, ShinJae-Gook, ShonJi-Hong, YeoChang-Woo

Paper Details 
Original Abstract of the Article :
AIMS: The primary objective of this study was to evaluate the effects of Ginkgo biloba extracts (GBE) on the pharmacokinetics of cilostazol and its metabolites. The secondary objective was to assess the effect of GBE on the pharmacodynamics of cilostazol. METHODS: A randomized, double-blind, two-wa...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004402/

データ提供:米国国立医学図書館(NLM)

A Curious Case of Cilostazol and Ginkgo Biloba

The interaction between medications can be quite tricky, like trying to navigate a sandstorm in the desert. This research explores the potential effects of [Ginkgo biloba extracts (GBE)] on the [pharmacokinetics] and [pharmacodynamics] of [cilostazol]. The authors used a rigorous [randomized, double-blind, two-way crossover study] to investigate these interactions, hoping to provide a clearer picture of the effects of GBE on cilostazol.

Unveiling the Secrets of Cilostazol and Ginkgo Biloba

The researchers found that co-administration of GBE did not have a significant impact on the [pharmacokinetics] of cilostazol. However, they observed a remarkable, but not statistically significant, increase in the [inhibition of platelet aggregation] when cilostazol was combined with GBE. This observation suggests a possible [pharmacodynamic interaction] between these two drugs.

Navigating the Uncertainties of Drug Interactions

While further research is needed to confirm this potential interaction, this study provides valuable information for healthcare providers who prescribe both cilostazol and Ginkgo biloba. It highlights the importance of considering potential interactions when managing patient medications. It is always best to consult with a healthcare professional before taking any medications, especially if you are considering using [herbal supplements] in conjunction with prescribed medications.

Dr.Camel's Conclusion

This research is like a desert mirage, tempting us with the possibility of an interaction between cilostazol and Ginkgo biloba. While the findings are intriguing, more research is needed to confirm these interactions and understand the implications for patient care. The importance of safe and effective medication use is like a guiding star in the desert, reminding us to always prioritize patient well-being.

Date :
  1. Date Completed 2015-02-07
  2. Date Revised 2022-03-18
Further Info :

Pubmed ID

24001154

DOI: Digital Object Identifier

PMC4004402

Related Literature

SNS
PICO Info
in preparation
Languages

English

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