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Long-term effects of statin treatment in elderly people: extended follow-up of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER).

Author: BriggsAndrew, BuckleyBrendan M, ComberHarry, FordIan, JukemaJ Wouter, KearneyPatricia M, LloydSuzanne M, MarchbankLaura, PackardChristopher J, PerryIvan, SattarNaveed, StottDavid J, TrompetStella, WestendorpRudi G J, de CraenAnton J M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the long-term benefits and safety of pravastatin treatment in older people using post-trial follow-up data from the PROSPER study. The findings aim to assess the long-term impact of pravastatin on coronary outcomes, stroke, all-cause mortality, and cancer risk.
Paper Details　
Original Abstract of the Article :
The PROspective Study of Pravastatin in the Elderly at Risk (PROSPER), a placebo-controlled trial of pravastatin, demonstrated a 19% reduction in coronary outcomes (p=0.006) after a mean of 3.2 years, with no impact on stroke outcomes or all-cause mortality. However, there was a suggestion of increa...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759378/

データ提供：米国国立医学図書館（NLM）

Long-Term Effects of Statin Treatment in Elderly People: Extended Follow-Up of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER)

Statins, a class of drugs commonly used to lower cholesterol, have become a mainstay in cardiovascular disease management. This study investigates the long-term effects of pravastatin treatment in elderly individuals, building upon the PROSPER study, which initially demonstrated a reduction in coronary outcomes. Researchers conducted an extended follow-up of PROSPER participants, analyzing the long-term benefits and safety of pravastatin treatment. The study found that pravastatin continued to show a beneficial effect on coronary outcomes, with no significant impact on stroke outcomes or all-cause mortality. However, the study also noted a suggestion of increased cancer risk, highlighting the importance of considering potential side effects in long-term treatment.

Navigating the Long-Term Effects of Statins

This study provides valuable insights into the long-term effects of statin treatment in elderly individuals, offering a more nuanced understanding of the benefits and risks associated with this widely used medication. The study's findings underscore the importance of carefully weighing the potential benefits and risks of statin treatment in the context of individual patient needs and medical history.

The Shifting Sands of Cardiovascular Health

As a researcher, I am deeply interested in the complex interplay between aging, cardiovascular health, and medication use. This study provides valuable data on the long-term effects of statin treatment in elderly individuals, emphasizing the importance of considering the potential risks and benefits of long-term medication use. It highlights the need for ongoing research to refine treatment strategies and optimize patient outcomes.

Dr.Camel's Conclusion

This extended follow-up of the PROSPER study provides valuable insights into the long-term effects of pravastatin treatment in elderly individuals, highlighting both its potential benefits and risks. It underscores the importance of carefully considering individual patient needs and medical history when making decisions about long-term statin treatment.

Date :
  1. Date Completed 2014-04-02
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

24023757

DOI: Digital Object Identifier

PMC3759378

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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