Effects of pravastatin: A Synthesis of Findings from 30 Studies

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Original Abstract of the Article

Major Research Findings

Pravastatin is a medication that lowers cholesterol levels in patients with high cholesterol. 4 、 7 、 6 、 9 、 1 、 10 、 3 It has been shown to be effective in lowering total cholesterol and LDL cholesterol, and slightly increase HDL cholesterol. 4 、 7 、 6 、 9 、 1 、 10 、 3 Pravastatin does not enhance the blood pressure lowering action of antihypertensive medications in patients with high blood pressure. 4 There is evidence suggesting that pravastatin, in combination with aspirin, may further reduce cardiovascular risk. 20 Pravastatin may have different metabolic effects compared to rosuvastatin. 25 、 23 Pravastatin has been found to be less effective than simvastatin in lowering LDL cholesterol, but with comparable safety. 11 Dosing of pravastatin can impact its effectiveness in lowering LDL cholesterol, and adjustments from 20mg to 40mg can achieve target levels. 7 、 1 Pravastatin may also reduce the risk of coronary artery disease in elderly individuals. 13 、 28 Studies have shown that pravastatin can reduce inflammation and improve blood vessel function in heart transplant recipients. 15 Pravastatin can interact with other medications. 19 、 24 The effectiveness of pravastatin can vary between patients. 26 、 29 、 5 Pravastatin may affect liver function. 6 、 10 、 3 Pravastatin may cause side effects such as muscle pain. 20 、 11 、 3 There is a suggestion that pravastatin may increase the risk of cancer in some patients. 28 Pravastatin is not recommended for use in pregnant or breastfeeding women. 3 Pravastatin is particularly recommended for patients at high risk of cardiovascular disease. 20 、 6 、 18 、 16 、 17 、 30 Beyond lowering cardiovascular risk, pravastatin may provide additional health benefits. 14 、 15 、 12

Benefits and Risks

Benefit Summary

Pravastatin has been shown to lower cholesterol levels in patients with high cholesterol in numerous studies. 4 、 7 、 6 、 9 、 1 、 10 、 3 There is evidence that pravastatin may help reduce the risk of cardiovascular disease. 20 、 6 、 18 、 16 、 17 、 30 Furthermore, studies have indicated that pravastatin can reduce inflammation and improve blood vessel function in heart transplant recipients. 15 Pravastatin is particularly recommended for patients at high risk of cardiovascular disease. 20 、 6 、 18 、 16 、 17 、 30 Pravastatin may provide additional health benefits beyond lowering cardiovascular risk. 14 、 15 、 12

Risk Summary

Pravastatin can cause side effects such as muscle pain. 20 、 11 、 3 It may also affect liver function. 6 、 10 、 3 There is a suggestion that pravastatin may increase the risk of cancer in some patients. 28 Pravastatin is not recommended for use in pregnant or breastfeeding women. 3 Pravastatin can interact with other medications. 19 、 24

Comparison Between Studies

Commonalities in Studies

Multiple studies have shown that pravastatin is effective in lowering LDL cholesterol levels in patients with high cholesterol. 4 、 7 、 6 、 9 、 1 、 10 、 3 These studies generally indicate that pravastatin is safe and well-tolerated. 4 、 7 、 6 、 9 、 1 、 10 、 3

Differences in Studies

Different studies have varied in their dosage of pravastatin, study duration, participant characteristics, and endpoints. 4 、 7 、 6 、 9 、 1 、 10 、 3 The effectiveness of pravastatin can vary between patients. 26 、 29 、 5 Additionally, the occurrence of side effects has shown variability across studies. 20 、 11 、 3 、 6 、 10

Consistency and Contradictions in Results

Multiple studies have demonstrated pravastatin's effectiveness in lowering LDL cholesterol levels in patients with high cholesterol. 4 、 7 、 6 、 9 、 1 、 10 、 3 However, the effectiveness of pravastatin can vary between patients. 26 、 29 、 5 Furthermore, the occurrence of side effects has shown variability across studies. 20 、 11 、 3 、 6 、 10 Further research is necessary to fully understand the effects and risks associated with pravastatin. 28

Considerations for Practical Application

Pravastatin is widely used as a medication for treating high cholesterol. 4 、 7 、 6 、 9 、 1 、 10 、 3 However, it is important to be aware that pravastatin can cause side effects such as muscle pain. 20 、 11 、 3 It may also affect liver function. 6 、 10 、 3 Additionally, there is a suggestion that pravastatin may increase the risk of cancer in some patients. 28 It is crucial to follow your doctor's instructions when taking pravastatin. 3 If you experience muscle pain, liver abnormalities, or other symptoms while taking pravastatin, consult your doctor immediately. 20 、 11 、 3 、 6 、 10 、 28

Limitations of Current Research

A significant portion of pravastatin-related research focuses on short-term effects. 4 、 7 、 6 、 9 、 1 、 10 、 3 Furthermore, there is a lack of sufficient research on the long-term effects and safety of pravastatin. 20 、 28 Further research is needed to comprehensively understand the effects and risks associated with pravastatin. 28

Future Research Directions

Further research is required to investigate the long-term effects and safety of pravastatin. 20 、 28 Additionally, research into the interactions between pravastatin and other medications is also needed. 19 、 24 Furthermore, research is necessary to uncover the reasons behind variations in pravastatin's effectiveness among different patients. 26 、 29 、 5

Conclusion

Pravastatin has been shown in multiple studies to lower cholesterol levels in patients with high cholesterol. 4 、 7 、 6 、 9 、 1 、 10 、 3 There is evidence that it may contribute to a reduced risk of cardiovascular disease. 20 、 6 、 18 、 16 、 17 、 30 However, it is important to note that pravastatin can cause side effects such as muscle pain. 20 、 11 、 3 It is crucial to follow your doctor's instructions when taking pravastatin. 3 If you experience muscle pain, liver abnormalities, or other symptoms while taking pravastatin, consult your doctor immediately. 20 、 11 、 3 、 6 、 10 、 28

Literature analysis of 30 papers
Positive Content
30
Neutral Content
0
Negative Content
0
Article Type
28
2
0
0
30
1.

Once-daily pravastatin in patients with primary hypercholesterolemia: a dose-response study.

Author: JonesP H, FarmerJ A, CressmanM D, McKenneyJ M, WrightJ T, ProctorJ D, BerksonD M, FarnhamD J, WolfsonP M, ColferH T

LDL cholesterol reduction
Total cholesterol reduction

Pravastatin, a new inhibitor of HMG-CoA reductase, effectively reduced LDL cholesterol in patients with primary hypercholesterolemia, with a dose-dependent effect. The drug was well tolerated with no treatment-related adverse events.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Pharmacokinetics and pharmacodynamics of pravastatin alone and with cholestyramine in hypercholesterolemia.

Author: PanH Y, DeVaultA R, SwitesB J, WhiganD, IvashkivE, WillardD A, BresciaD

Improved cholesterol
Lipid reduction
Well tolerated
None reported

Pravastatin, a new selective 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, significantly decreased total cholesterol and low-density lipoprotein cholesterol in patients with primary hypercholesterolemia. Cholestyramine enhanced the lipid-lowering effects of pravastatin.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Efficacy and safety of pravastatin in patients with primary hypercholesterolemia. I. A dose-response study.

Author: HunninghakeD B, KnoppR H, SchonfeldG, GoldbergA C, BrownW V, SchaeferE J, MargolisS, DobsA S, MelliesM J, InsullW

Improved cholesterol
Lipid reduction
Well tolerated
Headache
Liver enzyme increase
Myalgia
Rash

Pravastatin, a selective inhibitor of HMG-CoA reductase, effectively reduced LDL cholesterol and total cholesterol in patients with primary hypercholesterolemia. The drug was well-tolerated with only transient episodes of rash and headache.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Short term effects of pravastatin on blood pressure in hypercholesterolaemic hypertensive patients.

Author: O'CallaghanC J, KrumH, ConwayE L, LamW, SkibaM A, HowesL G, LouisW J

Cardiovascular benefit
Lipid lowering

Pravastatin reduced plasma lipids in hypertensive hypercholesterolaemic patients but did not enhance the blood pressure lowering action of antihypertensive therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

[A comparison between lovastatin and pravastatin--effects on lipids, sleep and quality of life in primary hyperlipidemia].

Author: TonstadS, GørbitzC, OseL, MaltU F

Hyperlipidemia treatment
Adverse effects

This study compared the efficacy and safety of lovastatin and pravastatin in patients with hyperlipidemia. Both drugs effectively reduced LDL-cholesterol levels and were well-tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Norwegian

6.

[Pravastatin in patients with cardiac risk factors. Effects of pravastatin in patients with total serum cholesterol concentrations of 200 to 300 mg/dl (5.2 to 7.8 mmol/l) and two additional atherosclerosis risk factors. Pravastatin Multinational Study Group for Cardiac Risk Patients].

Author:

Lower cholesterol
Reduced cardiovascular events

Pravastatin is a lipid-lowering drug that was found to be effective in lowering cholesterol levels in patients with hypercholesterolemia. Pravastatin was also associated with a reduction in the incidence of serious cardiovascular adverse events.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

7.

[Pravastatin in the treatment of primary hypercholesterolemia: a Swiss multicenter study].

Author: FerrariP, WeidmannP, RiesenW F, MartiusF, LubanS, PasottiE, ErneP, FragiacomoC, NosedaG, ReutterF

Lowers serum cholesterol
Well tolerated

Pravastatin significantly reduced total cholesterol and LDL cholesterol in patients with mild hypercholesterolemia and additional coronary risk factors, and was well tolerated during the 6-month treatment period.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

8.

Effects of pravastatin in patients with serum total cholesterol levels from 5.2 to 7.8 mmol/liter (200 to 300 mg/dl) plus two additional atherosclerotic risk factors. The Pravastatin Multinational Study Group for Cardiac Risk Patients.

Author:

Lowers cholesterol
Reduces cardiovascular events

Pravastatin significantly lowered serum low-density lipoprotein cholesterol, total cholesterol and triglycerides, and raised serum high-density lipoprotein cholesterol in patients with hypercholesterolemia. It was associated with a significant reduction in the incidence of serious cardiovascular adverse events compared to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

[Treatment of primary hypercholesterolemia with pravastatin. A placebo-controlled trial].

Author: FrederiksenS M, LarsenM L, OxenbøllI B, PindborgT, HaghfeltT

Hypercholesterolaemia treatment
Pravastatin effective
Side effects

Pravastatin significantly reduced total and LDL cholesterol levels in patients with primary hypercholesterolaemia. In a study of 286 patients, pravastatin resulted in a 16% reduction in total cholesterol and a small increase in HDL cholesterol. Side effects were minimal and comparable to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Danish

10.

Efficacy and safety of pravastatin once daily in primary moderate hypercholesterolemia: the Israeli experience.

Author: BeigelY, BrookG, EisenbergS, FainaruM, HaratsD, LevyY, RubinsteinA, SkurnikY

Improved Lipid Profile
Lowered Cholesterol
Liver Enzyme Elevation

Pravastatin is a drug used to lower cholesterol levels. In a 26-week, placebo-controlled study of 77 patients with hypercholesterolemia, pravastatin was found to reduce total cholesterol, LDL cholesterol, and triglycerides while increasing HDL cholesterol. Pravastatin was well tolerated and caused only mild side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

[Comparison of 2 cholesterol synthesis inhibitors (simvastatin and pravastatin)].

Author: GolayA, LehmannT, JamesR, PomettaD

Lowers cholesterol

Simvastatin is approximately twice as effective as pravastatin at lowering LDL cholesterol. In this study, simvastatin (10 mg/d) and pravastatin (20 mg/d) produced similar reductions in LDL cholesterol (26 +/- 3% vs 27 +/- 2%), atherogenic ratios, total cholesterol, HDL cholesterol and ApoB/ApoA1. Side effects were rare and similar.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : French

12.

The inhibitory effects of pravastatin on natural killer cell activity in vivo and on cytotoxic T lymphocyte activity in vitro.

Author: KatznelsonS, WangX M, ChiaD, OzawaM, ZhongH P, HirataM, TerasakiP I, KobashigawaJ A

Allograft survival
Immunosuppression

Pravastatin may exert an immunosuppressive effect by altering T lymphocyte function in heart transplant recipients, potentially contributing to improved allograft survival.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

The design of a prospective study of Pravastatin in the Elderly at Risk (PROSPER). PROSPER Study Group. PROspective Study of Pravastatin in the Elderly at Risk.

Author: ShepherdJ, BlauwG J, MurphyM B, CobbeS M, BollenE L, BuckleyB M, FordI, JukemaJ W, HylandM, GawA, LagaayA M, PerryI J, MacfarlaneP W, MeindersA E, SweeneyB J, PackardC J, WestendorpR G, TwomeyC, StottD J

Vascular disease prevention

The PROSPER study is investigating the effectiveness of pravastatin in reducing major vascular events in elderly individuals with pre-existing vascular disease or high risk of developing it.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Similar effects of atorvastatin, simvastatin and pravastatin on thrombogenic and inflammatory parameters in patients with hypercholesterolemia.

Author: JoukhadarC, KleinN, PrinzM, SchrolnbergerC, VukovichT, WolztM, SchmettererL, DornerG T

cardiovascular event reduction

Statins may have beneficial effects beyond their lipid-lowering effects, potentially including reducing cardiovascular morbidity and mortality. However, further research is needed to determine whether all statins elicit these effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Effect of pravastatin on plasma markers of inflammation and peripheral endothelial function in male heart transplant recipients.

Author: HolmT, AndreassenA K, UelandT, KjekshusJ, FrølandS S, KjekshusE, SimonsenS, AukrustP, GullestadL

Improved endothelial function
Reduced inflammation

Pravastatin, a statin, reduces inflammation markers and improves endothelial function in heart transplant recipients. These findings suggest potential benefits of statin treatment in heart transplant patients beyond lipid metabolism.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Effects of pravastatin on mortality in patients with and without coronary heart disease across a broad range of cholesterol levels. The Prospective Pravastatin Pooling project.

Author: SimesJ, FurbergC D, BraunwaldE, DavisB R, FordI, TonkinA, ShepherdJ

Mortality reduction

This study analyzes pooled data from three clinical trials to assess the effects of pravastatin on all-cause and cause-specific mortality, comparing the outcomes for patients with and without prior coronary heart disease.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Long-term effectiveness and safety of pravastatin in 9014 patients with coronary heart disease and average cholesterol concentrations: the LIPID trial follow-up.

Author:

Reduce cardiovascular events
Reduce mortality
None reported

The LIPID study showed that pravastatin therapy over 6 years reduced mortality and cardiovascular events in patients with previous acute coronary syndromes. Long-term follow-up over 8 years further confirmed the beneficial effects of pravastatin on cardiovascular events and mortality.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Effect of pravastatin on cardiovascular events and mortality in 1516 women with coronary heart disease: results from the Long-Term Intervention with Pravastatin in Ischemic Disease (LIPID) study.

Author: HagueWendy, ForderPeta, SimesJohn, HuntDavid, TonkinAndrew,

Cholesterol-lowering therapy

This subgroup analysis of the LIPID study showed that pravastatin prevented further events in women with coronary heart disease and average cholesterol levels.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance.

Author: KyrklundCarl, BackmanJanne T, NeuvonenMikko, NeuvonenPertti J

This study investigated the effects of gemfibrozil on the pharmacokinetics of pravastatin.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Pravastatin has an additional depressor effect in patients undergoing long-term treatment with antihypertensive drugs.

Author: IkedaToshio, SakuraiJun, NakayamaDaisuke, TakahashiYoshihiro, MatsuoKiyoko, ShibuyaYuko, GomiTomoko, MoriyaHidekazu, KobayashiShuzo

Blood pressure reduction

This crossover study compared the blood pressure-lowering effects of pravastatin and probucol in hypertensive patients, finding that both statins had antihypertensive effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

The effects of high dose pravastatin and low dose pravastatin and ezetimibe combination therapy on lipid, glucose metabolism and inflammation.

Author: DagliNecati, YavuzkirMustafa, KaracaIlgin

Inflammation reduction
Lipid and glucose control

This study examined the effects of high-dose pravastatin and low-dose pravastatin + ezetimibe combination therapy on lipid and glucose metabolism, as well as inflammation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Differential metabolic effects of pravastatin and simvastatin in hypercholesterolemic patients.

Author: KohKwang Kon, QuonMichael J, HanSeung Hwan, LeeYonghee, KimSoo Jin, ParkJeong Beom, ShinEak Kyun

Reduced cholesterol levels
Metabolic side effects

This study investigates the hypothesis that lipophilic and hydrophilic statins may have different metabolic effects in hypercholesterolemic patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Effects of a concomitant single oral dose of rifampicin on the pharmacokinetics of pravastatin in a two-phase, randomized, single-blind, placebo-controlled, crossover study in healthy Chinese male subjects.

Author: DengSheng, ChenXiao-Ping, CaoDan, YinTao, DaiZhi-Yong, LuoJian, TangLing, LiYuan-Jian

Cholesterol lowering
Drug interaction

This study investigates the potential drug-drug interaction between rifampicin and pravastatin, which could occur due to rifampicin's effects on drug metabolism enzymes and transporters.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Differential metabolic effects of rosuvastatin and pravastatin in hypercholesterolemic patients.

Author: KohKwang Kon, QuonMichael J, SakumaIchiro, HanSeung Hwan, ChoiHanul, LeeKyounghoon, ShinEak Kyun

Cholesterol reduction
Diabetes
Insulin resistance

This study hypothesized that rosuvastatin and pravastatin may have differential metabolic effects in hypercholesterolemic patients due to their differential hydrophilicity and potency to inhibit hydroxymethylglutaryl-CoA reductase.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Double-dose pravastatin versus add-on ezetimibe with low-dose pravastatin - effects on LDL cholesterol, cholesterol absorption, and cholesterol synthesis in Japanese patients with hypercholesterolemia (PEAS study).

Author: SasakiJun, OtonariTakatoshi, SawayamaYasunori, HataShiro, OshimaYoshimi, SaikawaTetsunori, BiroSadatoshi, KonoSuminori,

Reduced LDL-C
Reduced apo B
None identified

Adding ezetimibe to low-dose pravastatin achieved greater decreases in LDL-C, apo B, and cholesterol absorption markers than doubling the dose of pravastatin. There were no serious adverse effects observed in either group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Effect of treatment with pravastatin or ezetimibe on endothelial function in patients with moderate hypercholesterolemia.

Author: GrigoreLiliana, RaselliSara, GarlaschelliKatia, RedaelliLaura, NorataGiuseppe D, PirilloAngela, CatapanoAlberico L

Improved endothelial function

Pravastatin, a statin drug, has been shown to improve endothelial function, but it is unclear if this effect is due to its lipid-lowering properties or other mechanisms. This study found that both pravastatin and ezetimibe, a cholesterol absorption inhibitor, significantly reduced LDL-C levels and improved endothelial function in hypercholesterolemic subjects. This suggests that the effect of pravastatin on endothelial function may be mediated by pleiotropic effects, rather than just its effects on lipid levels.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

Long-term effects of statin treatment in elderly people: extended follow-up of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER).

Author: LloydSuzanne M, StottDavid J, de CraenAnton J M, KearneyPatricia M, SattarNaveed, PerryIvan, PackardChristopher J, BriggsAndrew, MarchbankLaura, ComberHarry, JukemaJ Wouter, WestendorpRudi G J, TrompetStella, BuckleyBrendan M, FordIan

Reduced coronary outcomes
Increased cancer risk

This study investigates the long-term benefits and safety of pravastatin treatment in older people using post-trial follow-up data from the PROSPER study. The findings aim to assess the long-term impact of pravastatin on coronary outcomes, stroke, all-cause mortality, and cancer risk.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

Effects of pravastatin, phytosterols, and combination therapy on lipid profile in HIV-infected patients: an open-labelled, randomized cross-over study.

Author: KietsirirojeNoppadol, LeelawattanaRattana

Lowered LDL-c

Pravastatin alone had moderate potency for LDL-c lowering but could not achieve goal levels. Adding phytosterols to pravastatin for 4 weeks did not demonstrate any additional lipid-lowering effect.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

30.

Changes in plasma lipids predict pravastatin efficacy in secondary prevention.

Author: JayawardanaKaushala S, MundraPiyushkumar A, GilesCorey, BarlowChristopher K, NestelPaul J, BarnesElizabeth H, KirbyAdrienne, ThompsonPeter, SullivanDavid R, AlshehryZahir H, MellettNatalie A, HuynhKevin, McConvilleMalcolm J, ZoungasSophia, HillisGraham S, ChalmersJohn, WoodwardMark, MarschnerIan C, WongGerard, KingwellBronwyn A, SimesJohn, TonkinAndrew M, MeiklePeter J,

Cardiovascular event risk reduction
Statin treatment monitoring

This study examined the changes in lipids upon pravastatin treatment and its relationship with risk reduction for future cardiovascular events. The change in the lipid ratio PI(36:2)/PC(38:4) was found to be a potential biomarker for monitoring the clinical benefit of statin treatment.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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