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Role of CFTR in oxidative stress and suicidal death of renal cells during cisplatin-induced nephrotoxicity.

Author: CougnonM, DurantonC, MelisN, MograbiB, RuberaI, TaucM

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Cisplatin-induced nephrotoxicity is a major limitation of its clinical use. This study investigated whether inhibiting CFTR, a chloride channel involved in glutathione (GSH) transport, could protect against cisplatin-induced nephrotoxicity. The specific CFTR inhibitor CFTR(inh)-172 prevented cisplatin-induced cell death and apoptosis by modulating the intracellular reactive oxygen species balance and GSH concentration. This protective effect was observed both in vitro and in vivo, without affecting cisplatin uptake or DNA adduct formation. These findings suggest that inhibiting CFTR may be a novel therapeutic approach to prevent cisplatin-induced nephrotoxicity.
Paper Details　
Original Abstract of the Article :
The clinical use of the antineoplastic drug cisplatin is limited by its deleterious nephrotoxic side effect. Cisplatin-induced nephrotoxicity is associated with an increase in oxidative stress, leading ultimately to renal cell death and irreversible kidney dysfunction. Oxidative stress could be modi...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824665/

データ提供：米国国立医学図書館（NLM）

Protecting the Kidneys from Cisplatin Toxicity

Cisplatin, a powerful chemotherapy drug, is often used to treat various cancers. However, its use can be limited by a serious side effect: nephrotoxicity, or kidney damage. This study investigates the role of CFTR, a protein involved in chloride transport, in protecting against cisplatin-induced nephrotoxicity. The researchers explore whether inhibiting CFTR could prevent kidney cell death and dysfunction caused by cisplatin. The study aims to identify potential strategies to mitigate the harmful effects of cisplatin on the kidneys.

CFTR: A Potential Shield Against Cisplatin-Induced Nephrotoxicity

This study, like a desert explorer discovering a protective oasis, investigates the potential of CFTR inhibition in safeguarding the kidneys from the toxic effects of cisplatin. The researchers' findings suggest that blocking CFTR could prevent cell death and dysfunction in kidney cells exposed to cisplatin, potentially offering a new avenue for protecting the kidneys during chemotherapy.

Living with Chemotherapy

Chemotherapy is a powerful treatment for cancer, but it can have significant side effects. This study highlights the importance of research focused on mitigating these side effects and improving the quality of life for cancer patients. Understanding the mechanisms involved in cisplatin-induced nephrotoxicity is crucial for developing strategies to protect the kidneys during chemotherapy treatment.

Dr.Camel's Conclusion

Cisplatin is a valuable weapon in the fight against cancer, but its nephrotoxic side effects can be a major concern. This study, like a wise old camel navigating a treacherous desert, sheds light on the potential protective role of CFTR in safeguarding the kidneys during chemotherapy. The findings open up new possibilities for protecting vital organs during cancer treatment, potentially improving the quality of life for cancer patients.

Date :
  1. Date Completed 2014-03-12
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

24091660

DOI: Digital Object Identifier

PMC3824665

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・Side Effects of cisplatin injection
SNS
PICO Info
in preparation
Languages

English

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