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Sexual side effects of serotonergic antidepressants: mediated by inhibition of serotonin on central dopamine release?

Author: BijlsmaElisabeth Y, ChanJohnny S W, MillanMark J, OlivierBerend, OostingRonald S, VeeningJan G, WaldingerMarcel D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Antidepressants increasing serotonin neurotransmission, like SSRIs, are more likely to cause sexual dysfunction. This can be mitigated by drugs that increase dopamine and noradrenaline signaling.
Paper Details　
Original Abstract of the Article :
Antidepressant-induced sexual dysfunction adversely affects the quality of life of antidepressant users and reduces compliance with treatment. Animal models provide an instructive approach for examining potential sexual side effects of novel drugs. This review discusses the stability and reproducibi...See full text at original site
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引用元：
https://doi.org/10.1016/j.pbb.2013.10.004

データ提供：米国国立医学図書館（NLM）

Understanding the Sexual Side Effects of Antidepressants

This study examines the sexual side effects of antidepressants, particularly those that target serotonin signaling. It's like exploring a desert oasis where certain plants can have unexpected effects. The researchers used animal models to investigate the mechanisms behind these side effects, providing valuable insights into the complex interplay between neurotransmitters and sexual function.

Navigating the Desert of Sexual Side Effects

This study explores the sexual side effects of antidepressants, which can significantly impact patients' quality of life. The researchers found that certain antidepressants can interfere with dopamine signaling in the brain, leading to sexual dysfunction. It's like discovering that a seemingly helpful oasis can also harbor hidden dangers.

A New Oasis of Hope for Mental and Sexual Health

This study suggests that future research should focus on developing antidepressants that target both serotonin and dopamine signaling, potentially mitigating these unwanted side effects. It's like searching for a new oasis that offers both nourishment and vitality. The study's findings pave the way for a more balanced and effective treatment approach to mental health, without compromising sexual well-being.

Dr. Camel's Conclusion

This research is a reminder that even in the quest for a healthier mind, we must consider the impact on the whole body. It's like ensuring that the desert oasis we create provides not only water but also shade and shelter for those who seek refuge. This study is a testament to the importance of a holistic approach to mental health, addressing both emotional well-being and physical function.
Date :
  1. Date Completed 2015-05-11
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

24128918

DOI: Digital Object Identifier

10.1016/j.pbb.2013.10.004

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Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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