The effects of teriflunomide on lymphocyte subpopulations in human peripheral blood mononuclear cells in vitro.

Author: ArendtChristopher, DeloheryThomas, JonesCatherine, LiLi, LiuJingchun, ZhangDonghui

Paper Details 
Original Abstract of the Article :
Teriflunomide is an inhibitor of dihydro-orotate dehydrogenase (DHODH), and is hypothesized to ameliorate multiple sclerosis by reducing proliferation of stimulated lymphocytes. We investigated teriflunomide's effects on proliferation, activation, survival, and function of stimulated human periphera...See full text at original site
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引用元:
https://doi.org/10.1016/j.jneuroim.2013.10.003

データ提供:米国国立医学図書館(NLM)

Teriflunomide: A Multi-faceted Approach to Multiple Sclerosis

Multiple sclerosis (MS) is a complex neurological disorder that can have a devastating impact on a person’s life. Imagine a camel who’s been struck by a sandstorm, losing its way and struggling to navigate the desert. This study examines the effects of teriflunomide, a medication for MS, on different immune cell types.

The researchers investigated how teriflunomide affects the proliferation, activation, survival, and function of various lymphocyte subpopulations in human peripheral blood mononuclear cells. It’s like studying the intricate web of life in a desert ecosystem, understanding how different species interact with each other.

A Promising New Treatment for MS

The study revealed that teriflunomide can effectively inhibit the proliferation of T- and B-cells, potentially slowing down the progression of MS. It’s like finding a way to block the sandstorm’s path, protecting the camel from further damage. The study also highlighted the multifaceted nature of teriflunomide's effects on the immune system, demonstrating its potential to reduce inflammation and modulate immune responses.

Implications for Health and Lifestyle

The study offers hope for people living with MS, providing evidence that teriflunomide could be a valuable tool in managing this complex condition. It’s like a traveler who finds a safe haven in the desert, a place where they can rest and recover. Further research is needed to fully understand the long-term benefits and potential risks of teriflunomide.

Dr.Camel's Conclusion

This study reminds us that even the most challenging conditions, like MS, can be tackled through ongoing research and innovation. It’s like a desert traveler who never gives up hope, persevering through the toughest conditions. With continued exploration, we can develop new treatments that empower people living with MS to lead fulfilling lives.

Date :
  1. Date Completed 2014-01-30
  2. Date Revised 2022-03-10
Further Info :

Pubmed ID

24182769

DOI: Digital Object Identifier

10.1016/j.jneuroim.2013.10.003

Related Literature

SNS
PICO Info
in preparation
Languages

English

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