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Evaluation of the efficacy and safety of bazedoxifene/conjugated estrogens for secondary outcomes including vasomotor symptoms in postmenopausal women by years since menopause in the Selective estrogens, Menopause and Response to Therapy (SMART) trials.

Author: AbrahamLucy, BushmakinAndrew G, CappelleriJoseph C, ChinesArkadi A, MirkinSebastian, PinkertonJoann V, RacketaJill, ShiHarry

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the influence of years since menopause (YSM) on the effects of bazedoxifene/conjugated estrogens (BZA/CE), a tissue-selective estrogen complex (TSEC).
Paper Details　
Original Abstract of the Article :
Bazedoxifene/conjugated estrogens (BZA/CE), a novel tissue-selective estrogen complex (TSEC), has been evaluated in the Selective estrogens, Menopause And Response to Therapy (SMART) trials. Secondary outcomes from these trials were evaluated to determine whether the effects of BZA/CE are influenced...See full text at original site
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引用元：
https://doi.org/10.1089/jwh.2013.4392

データ提供：米国国立医学図書館（NLM）

Bazedoxifene/Conjugated Estrogens: Evaluating Efficacy and Safety in Postmenopausal Women

The complexities of menopause continue to be a subject of extensive research, with a focus on finding safe and effective treatments for associated symptoms. This study delves into the effectiveness of bazedoxifene/conjugated estrogens (BZA/CE), a novel tissue-selective estrogen complex, in addressing various postmenopausal health concerns, including vasomotor symptoms. Researchers explored the efficacy of BZA/CE across different stages of menopause, analyzing its effects on a wide range of health outcomes.

Understanding the Impact of BZA/CE on Postmenopausal Health

The study's findings provide valuable insights into the efficacy and safety of BZA/CE for managing various postmenopausal symptoms. Researchers observed that BZA/CE effectively reduced vasomotor symptoms and exhibited a favorable safety profile. Furthermore, the study's analysis revealed that the effects of BZA/CE are not significantly influenced by the number of years since menopause, suggesting its potential applicability across different stages of this life transition.

A Comprehensive Approach to Postmenopausal Health

This study emphasizes the importance of a comprehensive approach to managing postmenopausal health. The research findings highlight the potential benefits of BZA/CE in addressing various symptoms, including vasomotor symptoms. The study's focus on long-term safety and efficacy underscores the need for continued research to ensure the optimal use of this medication in postmenopausal women.

Dr.Camel's Conclusion

This study provides valuable information for healthcare providers and postmenopausal women seeking effective management of menopause-related symptoms. The findings suggest that BZA/CE can be a safe and effective treatment option for managing vasomotor symptoms and other postmenopausal health concerns. The study's focus on the long-term effects of BZA/CE across different stages of menopause highlights the importance of considering individual patient needs and preferences when choosing treatment options.

Date :
  1. Date Completed 2014-03-17
  2. Date Revised 2021-01-21
Further Info :

Pubmed ID

24206058

DOI: Digital Object Identifier

10.1089/jwh.2013.4392

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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