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Genetic mutations in the treatment of anaplastic thyroid cancer: a systematic review.

Author: CarlomagnoChiara, CinelliMariapia, Di CrescenzoVincenzo, GarziAlfredo, GuerraAnna, TonaccheraMassimo, VitaleMario, ZeppaPio

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Anaplastic thyroid cancer (ATC) is a rare and aggressive disease with a median survival of only 6 months despite multidisciplinary care. Surgery is often palliative, and multidisciplinary care includes surgery, loco-regional radiotherapy, and systemic therapy. Emerging kinase-targeted inhibitors show promise as novel therapeutic tools, targeting the numerous molecular alterations found in ATC.
Paper Details　
Original Abstract of the Article :
Anaplastic thyroid cancer (ATC) is a rare, lethal disease associated with a median survival of 6 months despite the best multidisciplinary care. Surgical resection is not curative in ATC patients, being often a palliative procedure. Multidisciplinary care may include surgery, loco-regional radiother...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851243/

データ提供：米国国立医学図書館（NLM）

Anaplastic Thyroid Cancer: Navigating a Complex Landscape

Anaplastic thyroid cancer (ATC) is a rare and aggressive form of cancer, often presenting as a formidable challenge for healthcare providers. This systematic review examines the prevalence of genetic alterations in ATC and explores the potential of targeted therapies to combat this disease. It's like mapping the terrain of a treacherous desert, identifying key landmarks and strategizing the best routes for survival.

Unveiling Genetic Targets for Therapy

The review highlights the numerous molecular alterations detected in ATC, providing a comprehensive picture of the genetic landscape of this disease. These genetic alterations serve as potential targets for targeted therapies, like finding vulnerable spots in a desert fortress that can be exploited for a successful attack. The study specifically focuses on kinase-targeted inhibitors, a class of drugs that can effectively block the activity of specific proteins involved in cancer cell growth.

Hope on the Horizon for ATC Patients

The review underscores the growing importance of personalized medicine, where treatments are tailored to the specific genetic profile of each patient. It's like understanding the unique challenges of navigating a particular desert region, allowing for better preparation and a higher chance of success. This personalized approach could lead to more effective and targeted treatments for ATC, offering hope for improved outcomes for patients facing this challenging disease.

Dr.Camel's Conclusion

This systematic review sheds light on the complex genetic landscape of anaplastic thyroid cancer, highlighting the potential for targeted therapies to improve treatment outcomes. It's a testament to the ongoing scientific quest to develop effective and personalized treatments for a wide range of cancers, much like tireless desert explorers seeking new paths to conquer challenging environments and unlock hidden treasures.

Date :
  1. Date Completed 2014-08-20
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

24267151

DOI: Digital Object Identifier

PMC3851243

SNS
PICO Info
in preparation
Languages

English

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