Effective treatment of thyroid cancer: A Synthesis of Findings from 23 Studies

  1. Home
  2. Effective treatment of thyroid cancer
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effective treatment of thyroid cancer: A Synthesis of Findings from 23 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effective treatment of thyroid cancer: A Synthesis of Findings from 23 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Many studies are investigating effective treatments for thyroid cancer. There has been an increase in basic and clinical research regarding advanced thyroid cancer because effective treatments have been limited. 4 reviewed the effects of new drug treatments for advanced thyroid cancer and reported the effectiveness and side effects of various drugs, including kinase inhibitors. 20 found that apatinib, a vascular endothelial growth factor receptor inhibitor, was effective in delaying the progression of radioactive iodine-refractory differentiated thyroid cancer. These studies suggest progress in the development of new treatments for advanced thyroid cancer.

Treatment Summary

4 found that drug treatments like kinase inhibitors showed effectiveness in some patients with advanced thyroid cancer. 20 found apatinib to be effective for patients with radioactive iodine-refractory differentiated thyroid cancer.

Benefits and Risks

Benefits Summary

Research has shown that drug treatments like kinase inhibitors can be effective for some patients with advanced thyroid cancer. Apatinib has also been reported to be effective for patients with radioactive iodine-refractory differentiated thyroid cancer.

Risks Summary

Drug treatments, such as kinase inhibitors, can have side effects such as hypertension, hand-foot syndrome, and diarrhea. 4

Research Comparisons

Commonalities

Many studies focus on developing new treatments for advanced thyroid cancer.

Differences

The type of thyroid cancer, treatments, and evaluation criteria vary by study. Some studies conduct randomized controlled trials to evaluate the effectiveness of new treatments, while others use observational studies.

Consistency and Contradictions in Findings

Some studies show the effectiveness of new treatments for advanced thyroid cancer. However, these studies have limitations such as limited patient numbers or biases in research methods. Therefore, it is difficult to apply these findings directly to clinical practice.

Considerations for Real-World Application

Treatment for advanced thyroid cancer depends on the patient's individual condition and disease stage. Therefore, it is important to consult with a doctor before starting new treatments. New treatments also carry the risk of side effects, so it is important to gather enough information beforehand.

Limitations of Current Research

Many studies on advanced thyroid cancer treatments have limited patient numbers, making it difficult to generalize findings. Some studies may also have biases in research methods, which can lower the reliability of the results.

Future Research Directions

Larger randomized controlled trials are needed to evaluate the effectiveness of new treatments for advanced thyroid cancer. Improving research methods is also important for increasing the reliability of results.

Conclusion

Research regarding advanced thyroid cancer treatments has made significant progress in recent years. However, further research is needed to develop more effective treatments. It is important to consult with a doctor to choose the right treatment for your individual needs.

Treatment List

• Kinase inhibitors • Apatinib • Radioactive iodine therapy

Literature analysis of 23 papers
Positive Content
22
Neutral Content
1
Negative Content
0
Article Type
4
6
19
9
21
1.

Pharmacotherapy for thyroid nodules. A systematic review and meta-analysis.

Author: RichterBernd, NeisesGudrun, ClarChristine

Nodular thyroid disease treatment
Atrial fibrillation
Hyperthyroidism
Reduced bone density

The study highlights the uncertainty surrounding the use of thyroxine suppressive treatment for nodular thyroid disease, emphasizing the need for more high-quality research.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

2.

Clinical review 170: A systematic review and metaanalysis of the effectiveness of radioactive iodine remnant ablation for well-differentiated thyroid cancer.

Author: SawkaAnna M, ThephamongkholKullathorn, BrouwersMelissa, ThabaneLehana, BrowmanGeorge, GersteinHertzel C

Distant metastases
Locoregional recurrence
Thyroid cancer recurrence

Radioactive iodine remnant ablation may reduce the risk of thyroid cancer recurrence after surgery, especially for locoregional recurrence and distant metastases, but the benefit for low-risk patients is unclear.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

3.

Decision aid on radioactive iodine treatment for early stage papillary thyroid cancer--a randomized controlled trial.

Author: SawkaAnna M, StrausSharon, BrierleyJames D, TsangRichard W, RotsteinLorne, RodinGary, GafniAmiram, EzzatShereen, ThabaneLehana, ThorpeKevin E, GoldsteinDavid P

Treatment for PTC

This article discusses the conflicting reports of benefit and the lack of long-term randomized controlled trials for adjuvant radioactive iodine (RAI) treatment after thyroidectomy in patients with early stage papillary thyroid carcinoma (PTC).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Pharmacotherapy options for advanced thyroid cancer: a systematic review.

Author: LerchChristian, RichterBernd

Improved survival
Increased risk of second cancers

This review of studies investigating drug treatment for advanced thyroid cancer found that while new drugs, especially kinase inhibitors, show promise, their effectiveness remains unclear due to the lack of adequate randomized controlled trials. The studies reviewed reported a median progression-free survival of around 12 months, with adverse events such as hypertension, hand-foot syndrome, and diarrhea.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

Clinical, safety, and economic evidence in radioactive iodine-refractory differentiated thyroid cancer: a systematic literature review.

Author: AndersonRoger T, LinnehanJohn E, TongbramVanita, KeatingKaren, WirthLori J

Thyroid cancer treatment

This study examines potential treatments for differentiated thyroid cancer (DTC) that has become resistant to radioactive iodine (RAI), a common treatment for this type of cancer. The review focuses on clinical trials of novel targeted therapies and evaluates their effectiveness, safety, and cost.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

6.

Genetic mutations in the treatment of anaplastic thyroid cancer: a systematic review.

Author: GuerraAnna, Di CrescenzoVincenzo, GarziAlfredo, CinelliMariapia, CarlomagnoChiara, TonaccheraMassimo, ZeppaPio, VitaleMario

Improved survival

Anaplastic thyroid cancer (ATC) is a rare and aggressive disease with a median survival of only 6 months despite multidisciplinary care. Surgery is often palliative, and multidisciplinary care includes surgery, loco-regional radiotherapy, and systemic therapy. Emerging kinase-targeted inhibitors show promise as novel therapeutic tools, targeting the numerous molecular alterations found in ATC.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

7.

Effects of short-term metformin therapy associated with levothyroxine dose decrement on TSH and thyroid hormone levels in patients with thyroid cancer.

Author: MousaviZ, DourandishL, RokniH, SadeghiR, Rasoul ZakaviS

Subclinical hyperthyroidism

A single-blind randomized controlled trial of 50 non-diabetic patients with DTC found that adding 500 mg of metformin to the drug regimen was not useful to compensate for a 33% reduction in levothyroxine dose.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

New therapeutic options for advanced forms of thyroid cancer.

Author: BernetVictor, SmallridgeRobert

Thyroid cancer treatment

While most people with thyroid cancer have a good prognosis, some experience aggressive forms of the disease that can be difficult to treat. New medications are being investigated for treating advanced thyroid cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

9.

Total or near-total thyroidectomy versus subtotal thyroidectomy for multinodular non-toxic goitre in adults.

Author: CirocchiRoberto, TrastulliStefano, RandolphJustus, GuarinoSalvatore, Di RoccoGiorgio, ArezzoAlberto, D'AndreaVito, SantoroAlberto, BarczyñskiMarcin, AveniaNicola

Safer option
Similar effectiveness
Undetected thyroid cancer

Total thyroidectomy (TT) and subtotal thyroidectomy (ST) are treatment options for multinodular non-toxic goitre. This study compares the effectiveness and safety of near-total thyroidectomy (near TT) to TT and ST.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

10.

Lenvatinib for the treatment of radioiodine-refractory differentiated thyroid carcinoma: a systematic review and indirect comparison with sorafenib.

Author: KawalecPawel, Malinowska-LipieńIwona, BrzostekTomasz, KózkaMaria

Improved survival
Sorafenib and lenvatinib efficacy
Thyroid cancer treatment
Orphan drug status

This systematic review compared the efficacy and safety of lenvatinib and sorafenib, two tyrosine kinase inhibitors (TKIs), for the treatment of advanced radioactive iodine-refractory differentiated thyroid cancer (RR-DTC).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

Differentiated Thyroid Cancer-Treatment: State of the Art.

Author: SchmidbauerBenedikt, MenhartKarin, HellwigDirk, GrosseJirka

DTC treatment

Differentiated thyroid cancer (DTC) is a rare type of cancer that usually has a good outcome. Treatment typically involves surgery, radioactive iodine, and thyroid hormone replacement. While most cases are cured with these methods, new treatments are being developed for rare cases that don't respond to radioactive iodine. These newer medications can slow down tumor growth but may have serious side effects and are only used for patients with severe symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

Cabozantinib and vandetanib for unresectable locally advanced or metastatic medullary thyroid cancer: a systematic review and economic model.

Author: TappendenPaul, CarrollChristopher, HamiltonJean, KaltenthalerEva, WongRuth, WadsleyJonathan, MossLaura, BalasubramanianSabapathy

Cabozantinib
Medullary thyroid cancer treatment
Vandetanib

Medullary thyroid cancer (MTC) is a rare cancer that can significantly impact patients' quality of life and survival. Cabozantinib and vandetanib are currently the most commonly used treatments for advanced MTC.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

13.

Lobectomy Compared to Total Thyroidectomy for Low-Risk Papillary Thyroid Cancer: A Systematic Review.

Author: Vargas-PintoSusana, Romero ArenasMinerva A

Improved PTC treatment

This study addressed the controversy surrounding the optimal extent of surgery for small and less aggressive papillary thyroid cancers (PTC), considering the 2015 American Thyroid Association (ATA) guidelines recommending thyroid lobectomy (TL) in certain cases.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

14.

A systematic review of lenvatinib and sorafenib for treating progressive, locally advanced or metastatic, differentiated thyroid cancer after treatment with radioactive iodine.

Author: FleemanNigel, HoutenRachel, ChaplinMarty, BealeSophie, BolandAngela, DundarYenal, GreenhalghJanette, DuarteRui, ShenoyAditya

Improved RR-DTC treatment

Radioactive iodine is an effective treatment for many patients with thyroid cancer, but some become refractory to treatment. This study focuses on radioactive iodine refractory differentiated thyroid cancer (RR-DTC).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

Lenvatinib and sorafenib for differentiated thyroid cancer after radioactive iodine: a systematic review and economic evaluation.

Author: FleemanNigel, HoutenRachel, BagustAdrian, RichardsonMarty, BealeSophie, BolandAngela, DundarYenal, GreenhalghJanette, HounsomeJuliet, DuarteRui, ShenoyAditya

DTC treatment

Thyroid cancer is a rare cancer, and differentiated thyroid cancer (DTC) is the most common type. Radioactive iodine is often used to treat DTC. For people who don't respond to radioactive iodine, treatment options are limited, and supportive care is often the only approach.

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

Management and follow-up of differentiated thyroid cancer not submitted to radioiodine treatment: a systematic review.

Author: GambaleCarla, EliseiRossella, MatroneAntonio

Improved DTC treatment

This study discussed the evolving treatment landscape for differentiated thyroid cancer (DTC), considering the increasing use of conservative surgery and the potential for alternative approaches to radioiodine (<sup>131</sup>I) therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

17.

Current surgical treatment of intermediate risk differentiated thyroid cancer: a systematic review.

Author: GuoMichael Y, WisemanJacob J, WisemanSam M

Adjuvant radioactive iodine
Avoidance of thyroid hormone
Comparable survival outcomes
Cost-effective TL
Lower complication risk
Lower recurrence risk
Simpler follow-up
Poorer outcomes for larger cancers
Risk of CT
Unclear threshold for TT

This review examines the extent of surgery (total thyroidectomy vs. thyroid lobectomy) for treating intermediate-risk differentiated thyroid cancer, considering the latest American Thyroid Association (ATA) guidelines and the potential benefits and risks of each approach.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Which is preferred for initial treatment of papillary thyroid cancer, total thyroidectomy or lobotomy?

Author: WuZhen, HanLin, LiWenlei, WangWei, ChenLiqaing, YaoYumin, WangYongkun

Thyroid cancer treatment

This study investigates the effectiveness of lobectomy versus total thyroidectomy as the initial surgical mode for thyroid cancer, based on data from patients treated in Liaocheng People's Hospital from 2015 to 2018.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Adjuvant radiotherapy and radioiodine treatment for locally advanced differentiated thyroid cancer: systematic review and meta-analysis.

Author: DicuonzoSamantha, PedrettiSara, MangoniMonica, MonariFabio, FanettiGiuseppe, BorsattiEugenio, LombardiDavide, VianelloFederica, IacoboneMaurizio, CorvòRenzo, MagriniStefano M, PappagalloGiovanni, ArcangeliStefano, D'AngelilloRolando M

EBRT efficacy
Locoregional control
Toxicity

The addition of external beam radiotherapy (EBRT) to radioiodine after surgery for locally advanced differentiated thyroid cancer may improve locoregional control. However, the benefit/harms balance is uncertain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

20.

Apatinib vs Placebo in Patients With Locally Advanced or Metastatic, Radioactive Iodine-Refractory Differentiated Thyroid Cancer: The REALITY Randomized Clinical Trial.

Author: LinYansong, QinShukui, LiZhiyong, YangHui, FuWei, LiShaohua, ChenWenxin, GaoZairong, MiaoWeibing, XuHuiqin, ZhangQing, ZhaoXinming, BaoJiandong, LiLinfa, RenYuan, LinChenghe, JingShanghua, MaQingjie, LiangJun, ChenGuang, ZhangHong, ZhangYifan, ZhouXianfeng, SangYaxiong, HouZhiguo

Improved overall survival
Prolonged PFS
Hand-foot syndrome
Hypertension
Proteinuria

Apatinib, a VEGFR-2 inhibitor, showed significant clinical benefits in patients with progressive locally advanced or metastatic radioactive iodine-refractory differentiated thyroid cancer (RAIR-DTC) in a phase 3 trial. The drug demonstrated prolonged progression-free survival (PFS) and overall survival with a manageable safety profile.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Complication Rates of Total Thyroidectomy vs Hemithyroidectomy for Treatment of Papillary Thyroid Microcarcinoma: A Systematic Review and Meta-analysis.

Author: HsiaoVivian, LightTyler J, AdilAbdullah A, TaoMichael, ChiuAlexander S, HitchcockMary, ArroyoNatalia, Fernandes-TaylorSara, FrancisDavid O

Low-risk cancers

Total thyroidectomy (TT) has been the primary treatment for papillary thyroid microcarcinomas (PTMCs), but current guidelines recommend hemithyroidectomy (HT) for select low-risk cancers. This study aims to further clarify the risk-benefit ratio of these two surgical approaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

22.

Safety and efficacy of ultrasound-guided thermal ablation in treating T1aN0M0 and T1bN0M0 papillary thyroid carcinoma: A meta-analysis.

Author: WangMei-Huan, LiuXiao, WangQian, ZhangHua-Wei

PTC treatment

Papillary thyroid cancer (PTC) is the most common type of thyroid tumor. Early diagnosis and treatment are crucial for improving prognosis. Thermal ablation (TA) has shown potential benefits in the treatment of PTC patients, but its safety and efficacy remain controversial. This meta-analysis evaluates the efficacy and safety of TA in patients with T1aN0M0 and T1bN0M0 PTC.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

[Hemithyroidectomy or total thyroidectomy for low-risk papillary thyroid cancer? : Surgical criteria for primary and secondary choice of treatment in an interdisciplinary treatment concept].

Author: DralleH, WeberF, MachensA, BrandenburgT, SchmidK W, Führer-SakelD

Oncological outcomes
Postoperative complications

This systematic review of 20 clinical studies found that hemithyroidectomy (HT) resulted in comparable long-term oncological outcomes to total thyroidectomy (TT) for low-risk papillary thyroid cancer (LRPTC) 1-4 cm in diameter, while postoperative complication rates were significantly lower for HT.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.