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Induction of oxiapoptophagy, a mixed mode of cell death associated with oxidative stress, apoptosis and autophagy, on 7-ketocholesterol-treated 158N murine oligodendrocytes: impairment by α-tocopherol.

Author: Delage-MourrouxRégis, DoriaMargaux, LizardGérard, NuryThomas, RiedingerJean Marc, VejuxAnne, ZarroukAmira

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that 7-Ketocholesterol (7KC) induces a complex mode of cell death on 158N murine oligodendrocytes. 7KC induced overproduction of reactive oxygen species (ROS), loss of transmembrane mitochondrial potential, caspase-3 activation, and nuclear condensation or fragmentation. Additionally, 7KC enhanced cytoplasmic membrane permeability to propidium iodide and induced acidic vesicular organelle formation. These effects were impaired by α-tocopherol.
Paper Details　
Original Abstract of the Article :
7-Ketocholesterol (7KC) has been suggested to induce a complex mode of cell death on monocytic cells: oxiapoptophagy (OXIdation, APOPTOsis, and autoPHAGY) (Monier et al. (2003) [12]). The aim of the present study, realized on 158N murine oligodendrocytes, was to bring new evidence on this mixed form...See full text at original site
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引用元：
https://doi.org/10.1016/j.bbrc.2013.11.081

データ提供：米国国立医学図書館（NLM）

Oxiapoptophagy: A Complex Mode of Cell Death Induced by 7-Ketocholesterol in Oligodendrocytes

7-Ketocholesterol (7KC), a cholesterol oxidation product, has been implicated in various cellular processes, including cell death. This study investigates the mechanism of cell death induced by 7KC in murine oligodendrocytes, exploring a complex mode of cell death termed oxiapoptophagy, which involves a combination of oxidative stress, apoptosis, and autophagy. The researchers aimed to elucidate the role of 7KC in triggering this unique form of cell death and to identify potential protective strategies.

7-Ketocholesterol Triggers Oxiapoptophagy in Oligodendrocytes

The study confirmed that 7KC induces oxiapoptophagy in oligodendrocytes, characterized by increased reactive oxygen species (ROS) production, loss of mitochondrial membrane potential, caspase-3 activation, and features of apoptosis and autophagy. Interestingly, α-tocopherol, a potent antioxidant, effectively impaired these 7KC-induced effects, suggesting a potential protective role against oxiapoptophagy.

Understanding the Role of Oxiapoptophagy in Neurological Disorders

This research provides valuable insights into the complex mechanisms of cell death triggered by 7KC, highlighting the role of oxiapoptophagy in oligodendrocyte injury. The study underscores the importance of understanding this unique mode of cell death and its potential implications for neurological disorders.

Dr.Camel's Conclusion

This research is like a camel caravan exploring the cellular desert, uncovering the complex mechanisms of cell death triggered by 7-ketocholesterol. The study sheds light on oxiapoptophagy, a unique form of cell death involving oxidative stress, apoptosis, and autophagy. It’s like finding a hidden oasis in the desert – a reminder that even in the seemingly barren landscape of cellular processes, there are intricate pathways and potential targets for therapeutic intervention.

Date :
  1. Date Completed 2014-09-02
  2. Date Revised 2023-08-15
Further Info :

Pubmed ID

24299956

DOI: Digital Object Identifier

10.1016/j.bbrc.2013.11.081

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・Side Effects of alpha-tocopherol
SNS
PICO Info
in preparation
Languages

English

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