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Systematically studying kinase inhibitor induced signaling network signatures by integrating both therapeutic and side effects.
Author: JiZhiwei, PengTao, ShaoHongwei, SuJing, ZhouXiaobo
Original Abstract of the Article :
Substantial effort in recent years has been devoted to analyzing data based large-scale biological networks, which provide valuable insight into the topologies of complex biological networks but are rarely context specific and cannot be used to predict the responses of cell signaling proteins to spe...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855094/
データ提供:米国国立医学図書館(NLM)
Deciphering the Kinase Inhibitor Code: A Personalized Approach to Drug Development
The field of [drug development] is rapidly evolving with the advent of [kinase inhibitors]. This study dives into the intricate world of [kinase inhibitor-induced signaling network signatures]. Researchers used [a novel strategy integrating multiplex data from the Library of Integrated Network-based Cellular Signatures (LINCS)] to investigate the effects of kinase inhibitors on cellular pathways. They discovered that [kinase inhibitors have specific pathway signatures] that can be used to predict their therapeutic and side-effect profiles. The study highlighted [the potential of using this approach for drug screening] and [personalizing treatment strategies].
Decoding the Kinase Inhibitor Language
This research unlocks the language of kinase inhibitors, providing a detailed map of their effects on cellular pathways. The study's findings demonstrate [the potential of using this approach to identify optimal drug targets and concentrations].
A Personalized Journey Through the Desert of Drug Development
Drug development is a complex and often challenging process. This study provides a new compass for navigating this desert, offering a personalized approach to [identifying effective and safe treatments] based on individual patient needs.
Dr. Camel's Conclusion
This study unveils the power of integrating multiple data sources to understand the complex effects of kinase inhibitors. The researchers have created a new map for navigating the desert of drug development, leading us towards more personalized and effective treatments.
Date :
- Date Completed 2015-03-02
- Date Revised 2021-10-21
Further Info :
Related Literature
English
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