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Effects of CYP2C19 and P450 oxidoreductase polymorphisms on the population pharmacokinetics of clobazam and N-desmethylclobazam in japanese patients with epilepsy.

Author: IshitsuTakateru, KanekoSunao, NagataRie, NakagawaKazuko, NakashimaHiroo, NishimuraMiki, OgusuNaoki, SaruwatariJunji, SeoTakayuki, ShimomasudaMasatsugu, TanikawaKoji, TsudaYoshiyuki, Yasui-FurukoriNorio

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the impact of CYP2C19 and POR genotypes on the pharmacokinetics of clobazam and its active metabolite, N-desmethylclobazam. The findings highlight the importance of considering these genetic factors when prescribing clobazam to patients.
Paper Details　
Original Abstract of the Article :
Clobazam (CLB) is a 1,5-benzodiazepine with antiepileptic properties. More than 70% of administered CLB is dealkylated to yield N-desmethylclobazam (N-CLB), a pharmacologically active metabolite, by cytochrome P450 (CYP) 3A4 and CYP2C19. The subsequent inactivation of N-CLB is primarily catalyzed by...See full text at original site
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引用元：
https://doi.org/10.1097/FTD.0000000000000015

データ提供：米国国立医学図書館（NLM）

Investigating the Influence of Genetic Variations on Clobazam Pharmacokinetics

The world of genetics is a vast and intricate landscape, much like the desert. This study explores the complex interplay between genetic variations and drug metabolism, focusing on the antiepileptic medication clobazam. The researchers investigated the influence of polymorphisms in CYP2C19 and P450 oxidoreductase (POR) on the pharmacokinetics of clobazam and its active metabolite, N-desmethylclobazam.

Genetic Variations Impact Drug Metabolism

The study revealed that genetic variations in CYP2C19 and POR significantly influenced the pharmacokinetic parameters of clobazam and N-desmethylclobazam. This discovery highlights the crucial role of genetics in drug metabolism and the potential for personalized medicine approaches in optimizing drug therapy. The researchers observed that individuals with specific genotypes exhibited variations in drug clearance and metabolism, leading to differences in drug levels and potential therapeutic effects.

Understanding the Impact of Genetics on Drug Response

The study underscores the importance of considering genetic variations when prescribing medication. The researchers' findings demonstrate that genetic testing could play a vital role in optimizing drug therapy and ensuring patient safety. By tailoring medication based on individual genetic profiles, healthcare professionals can potentially achieve more effective and personalized treatment outcomes.

Dr.Camel's Conclusion

The journey to understand the complex interplay between genetics and drug metabolism is an ongoing one. This study sheds light on the impact of genetic variations on the pharmacokinetics of clobazam, highlighting the need for personalized medicine approaches in optimizing drug therapy. The researchers' findings offer a glimpse into the future of medicine, where tailored treatments based on individual genetic profiles may become the norm.
Date :
  1. Date Completed 2015-01-12
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

24345815

DOI: Digital Object Identifier

10.1097/FTD.0000000000000015

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Languages

English

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