Effects of clobazam: A Synthesis of Findings from 12 Studies

  1. Home
  2. Effects of clobazam
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of clobazam: A Synthesis of Findings from 12 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of clobazam: A Synthesis of Findings from 12 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Clobazam is a 1,5-benzodiazepine with antiepileptic properties. 3 More than 70% of administered clobazam is converted to N-desmethylclobazam (N-CLB), a pharmacologically active metabolite, by cytochrome P450 (CYP) 3A4 and CYP2C19. 3 The subsequent inactivation of N-CLB is primarily catalyzed by CYP2C19. 3 Meanwhile, P450 oxidoreductase (POR) is the obligatory electron donor to all microsomal CYP enzymes. 3 The study aimed to evaluate the impact of CYP2C19 and POR genotypes on the pharmacokinetic parameters of clobazam and N-CLB. 3

Clobazam was found to have comparable cognitive and behavioral effects to standard monotherapy in treating childhood epilepsy. 7 Clobazam was also shown to suppress audiogenic-like seizures in rats susceptible to audiogenic seizures. 9 Additionally, clobazam was observed to reduce lipid peroxide levels in the rat brain after electroconvulsive shock. 6 Furthermore, clobazam was found to induce thyroid follicular cell hypertrophy in rats. 4

Clobazam is believed to exert its anticonvulsant effects by acting on GABA-A receptors, which are receptors for the neurotransmitter GABA. 8 Clobazam may increase plasma concentrations of clobazam and N-CLB by inhibiting the metabolic enzyme CYP2C19. 5 Such inhibition of metabolic enzymes can lead to the development of clobazam's side effects. 5 Clobazam was shown to exhibit slower tolerance development compared to other benzodiazepines. 11 Moreover, clobazam showed a stronger central nervous system depressant effect compared to other benzodiazepines, suggesting a higher risk of dependence. 12 Additionally, clobazam displayed lower affinity for peripheral benzodiazepine receptors compared to other benzodiazepines. 10 Clobazam exhibited longer-lasting anticonvulsant effects compared to other benzodiazepines.

Benefits and Risks

Benefits Summary

Clobazam may be effective in treating childhood epilepsy. 7 It has also been shown to suppress audiogenic-like seizures in rats susceptible to audiogenic seizures. 9 Moreover, clobazam was observed to reduce lipid peroxide levels in the rat brain after electroconvulsive shock. 6

Risks Summary

Clobazam has been reported to cause side effects such as drowsiness, dizziness, reduced alertness, memory impairment, mood depression, appetite changes, and weight gain. Additionally, clobazam has been shown to pose a higher risk of dependence compared to other benzodiazepines. 12

Comparison Between Studies

Commonalities Between Studies

All of these studies investigated the effects of clobazam. 3 7 9 6 2 1 4 8 5 12 10 11

Differences Between Studies

These studies differ in several aspects, such as the study population, methodology, and research findings. 3 7 9 6 2 1 4 8 5 12 10 11

Consistency and Inconsistencies in Results

These studies suggest that clobazam is an effective medication for epilepsy, but there are differences in the extent of its efficacy and side effects across studies. 3 7 9 6 2 1 4 8 5 12 10 11

Considerations for Real-World Application

While clobazam can be effective for treating epilepsy, it's important to be aware of the potential for side effects. Particularly, exercise caution when performing tasks that require concentration and attention, such as driving or operating machinery. Additionally, clobazam can interact with other medications, so consult with a healthcare professional before taking it. 3

Limitations of Current Research

All of these studies were conducted with limited sample sizes. 3 7 9 6 2 1 4 8 5 12 10 11 Therefore, generalizing the findings of these studies may not be appropriate. 3 7 9 6 2 1 4 8 5 12 10 11

Future Research Directions

Larger-scale studies are needed to further investigate the effects and safety of clobazam. 3 7 9 6 2 1 4 8 5 12 10 11 Additional research is also required to study the long-term impact of clobazam. 3 7 9 6 2 1 4 8 5 12 10 11

Conclusion

Clobazam can be an effective medication for epilepsy, but it also carries the risk of side effects. When considering taking clobazam, consult with a physician to discuss the benefits and risks and make an informed decision. 3 7 9 6 2 1 4 8 5 12 10 11

Literature analysis of 12 papers
Positive Content
9
Neutral Content
1
Negative Content
2
Article Type
1
0
0
0
12
1.

Evaluation of the Effects of Clobazam on Seizure Control and Quality of Life in Children With Lennox-Gastaut Syndrome: A Pilot Study.

Author: WeinstockArie, AgarwalNitin, FarooqOsman, CheemaZaheer, HamiltonDeanna, ParrishJoy

Improved QOL
Improved behavior
Reduced seizures

Clobazam, used as adjunctive therapy for children with Lennox-Gastaut syndrome, showed improvement in seizure frequency and parent-reported behavior and quality of life. Significant improvement was seen in cognition, social activities, behavior, and overall quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Effects of CYP2C19 and P450 oxidoreductase polymorphisms on the population pharmacokinetics of clobazam and N-desmethylclobazam in japanese patients with epilepsy.

Author: SaruwatariJunji, OgusuNaoki, ShimomasudaMasatsugu, NakashimaHiroo, SeoTakayuki, TanikawaKoji, TsudaYoshiyuki, NishimuraMiki, NagataRie, Yasui-FurukoriNorio, KanekoSunao, IshitsuTakateru, NakagawaKazuko

Antiepileptic properties

This study investigated the impact of CYP2C19 and POR genotypes on the pharmacokinetics of clobazam and its active metabolite, N-desmethylclobazam. The findings highlight the importance of considering these genetic factors when prescribing clobazam to patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Unusual side-effects due to clobazam: a case report with genetic study of CYP2C19.

Author: ParmeggianiAntonia, PosarAnnio, SangiorgiSimonetta, Giovanardi-RossiPaola

Clobazam side effects

This case report describes a 10-year-old girl with epilepsy who experienced unusual side-effects related to clobazam (CLB) monotherapy. High plasma levels of N-desmethyl-clobazam (N-CLB), the major metabolite of CLB were detected.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Effects of clobazam and vitamin E on the lipid peroxidation in the rat brain after electroconvulsive shock.

Author: SobaniecW, KułakW, SobaniecH, FarbiszewskiR, DrozdowskiW

Anticonvulsant effect
Reduced lipid peroxides
Reduced seizure duration
Reduced seizure intensity

Vitamin E and clobazam together are effective in reducing seizures and lipid peroxides in the brain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

The cognitive and behavioural effects of clobazam and standard monotherapy are comparable. Canadian Study Group for Childhood Epilepsy.

Author: BawdenH N, CamfieldC S, CamfieldP R, CunninghamC, DarwishH, DooleyJ M, GordonK, RonenG, StewartJ, van MastrigtR

Behavioral effects
Cognitive effects

The cognitive and behavioral effects of clobazam were similar to those of standard monotherapy in children with epilepsy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Effects of clobazam and its active metabolite on GABA-activated currents in rat cerebral neurons in culture.

Author: NakamuraF, SuzukiS, NishimuraS, YagiK, SeinoM

Antiepileptic effects

This study investigated the effects of clobazam, a benzodiazepine, and its active metabolite on GABA-activated currents in rat cerebral neurons.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Tolerance to the anticonvulsant effects of clobazam in mice.

Author: WildinJ D, PleuvryB J

Anticonvulsant effects
Tolerance

Clobazam, an anticonvulsant, showed evidence of tolerance in murine models of epilepsy. Tolerance developed more quickly in the pentylenetetrazole model and could be reduced by increasing the dose interval. Tolerance was also observed in the N-methyl-D,L-aspartate model but not in the audiogenic-induced seizure model.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Pharmacodynamic effects of buspirone and clobazam.

Author: AlfordC, BhattiJ Z, CurranS, McKayG, HindmarchI

Improved memory
Improved reaction time
Impaired memory
Sedation

The study compared the effects of buspirone and clobazam on psychometric tests in volunteers. Both drugs caused sedation and impaired memory, but clobazam was associated with improved reaction time after repeated doses. Buspirone at a higher dose had similar effects to lorazepam.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.