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An antiretroviral regimen containing 6 months of stavudine followed by long-term zidovudine for first-line HIV therapy is optimal in resource-limited settings: a prospective, multicenter study in China.

Author: BaiJinsong, GaoGuiju, GuoFuping, HanYang, HeYun, HuangAiqiong, LeiJunkang, LiTaisheng, LiYanling, LiYijia, LuHongzhou, LuoLing, LyeWei, SunYongtao, TangXiaoping, WangHuanling, WangHui, WuXinhua, XieJing, ZhangChengda, ZhangTong, ZhangXiaoying

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the efficacy and safety of an AZT-substitution regimen for HIV therapy, aiming for a regimen with better effectiveness, fewer adverse effects, and greater affordability in resource-limited settings.
Paper Details　
Original Abstract of the Article :
An zidovudine (AZT)-substitution regimen containing 24-week stavudine (d4T) followed by long-term AZT for HIV therapy is potential to trade off short-term AZT-related anemia and long-term risks associated with d4T in resource-limited settings. However, evidence is scarce. This study aims to assess t...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/24384425

データ提供：米国国立医学図書館（NLM）

Optimizing HIV Therapy in Resource-Limited Settings: A New Regimen for Effective Treatment

In the battle against HIV, access to effective and affordable treatment options is crucial. This study focuses on resource-limited settings, exploring the efficacy and safety of a novel zidovudine (AZT)-substitution regimen that incorporates stavudine (d4T) followed by long-term AZT therapy. By leveraging a prospective, multicenter study in China, researchers sought to identify a regimen that balances effectiveness, safety, and affordability.

A New Era for HIV Treatment in Resource-Limited Settings

The study's findings demonstrate the potential of the AZT-substitution regimen to offer an effective, safe, and cost-effective treatment option for HIV patients in resource-limited settings. By carefully balancing the short-term benefits of stavudine with the long-term efficacy of zidovudine, the regimen aims to provide a more comprehensive and sustainable solution for HIV management.

A New Hope for HIV Patients in Resource-Limited Settings

The research findings underscore the significance of tailoring treatment strategies to meet the unique needs of patients in different contexts. By focusing on finding a balance between effectiveness, safety, and affordability, this study provides a promising approach to HIV management in resource-limited settings. This research is a testament to the ongoing efforts to improve access to quality healthcare for those most in need.

Dr.Camel's Conclusion

This research is a beacon of hope for HIV patients in resource-limited settings. By introducing a new, effective, and affordable treatment regimen, the study highlights the importance of finding innovative solutions to tackle global health challenges. The careful balancing of short-term and long-term treatment strategies, combined with the consideration of affordability, makes this study a significant contribution to the field of HIV research.

Date :
  1. Date Completed 2014-06-27
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

24384425

DOI: Digital Object Identifier

24384425

Related Literature

Article Analysis
・Effects of d4t
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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