Psychomotor and subjective effects of bilastine, hydroxyzine, and cetirizine, in combination with alcohol: a randomized, double-blind, crossover, and positive-controlled and placebo-controlled Phase I clinical trials.

Author: AntonijoanRosa Maria, BallesterMaria Rosa, García-GeaConsuelo, GichIgnasi, MartínezJoan, ValienteRomán

Paper Details 
Original Abstract of the Article :
OBJECTIVE: The aim of this study was to compare the effects of concomitant administration of alcohol and bilastine versus alcohol alone on the central nervous system. METHODS: Twenty-four healthy young volunteers of both sexes participated in a randomized, double-blind, double-dummy, crossover, and...See full text at original site
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引用元:
https://doi.org/10.1002/hup.2378

データ提供:米国国立医学図書館(NLM)

Bilastine, Hydroxyzine, and Cetirizine: A Race to the Finish Line of Psychomotor Impairment

The interaction between alcohol and various medications is a complex area of study. This research focuses on the effects of combining alcohol with three antihistamine medications: bilastine, hydroxyzine, and cetirizine. The study aimed to compare the impact of these combinations on psychomotor performance and subjective feelings in healthy volunteers. The researchers used a randomized, double-blind, crossover design, allowing them to rigorously assess the effects of each drug combination.

Bilastine: A Potential Winner in the Psychomotor Race

The study's findings reveal a potential winner in the psychomotor performance race. While all active treatment combinations induced significant psychomotor impairment, bilastine (at a therapeutic dose) combined with alcohol exhibited less impairment compared to alcohol alone. The researchers observed a similar magnitude of impairment between bilastine and alcohol alone. This observation suggests that bilastine might be a more favorable choice than other antihistamines when combined with alcohol, potentially reducing the risk of significant psychomotor impairments.

A Journey Through the Desert of Psychomotor Impairment

This research offers valuable insights for individuals who enjoy an occasional drink while taking antihistamines. It sheds light on the potential impact of different antihistamines on psychomotor performance when combined with alcohol. The study, like a guide through a vast desert, provides insights into the potential consequences of specific drug combinations, helping us make informed choices about our health and well-being.

Dr. Camel's Conclusion

This research highlights the importance of understanding the potential interactions between medications and alcohol. It offers valuable information for individuals taking antihistamines, especially when considering alcohol consumption. Remember, like a wise traveler in a desert, it's crucial to be aware of the potential consequences of our choices.

Date :
  1. Date Completed 2014-11-21
  2. Date Revised 2014-03-04
Further Info :

Pubmed ID

24395298

DOI: Digital Object Identifier

10.1002/hup.2378

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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