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Evaluation of (131)I-pentamidine for scintigraphy of experimentally Leishmania tropica-infected hamsters.

Author: BekişRecep, ErÖzge, ErenMine Şencan, GirginkardeşlerNogay, IncebozTonay, LambrechtFatma Yurt, YilmazOsman, ÖzbilginAhmet

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

(131)I-Pentamidine scintigraphy showed poor sensitivity in detecting Leishmania tropica infection. The target-to-non-target ratio decreased over time.
Paper Details　
Original Abstract of the Article :
We aimed to assess the ability of (131)I-Pentamidine scintigraphy to detect the lesions of Leishmania tropica infection. An experimental model of cutaneous leishmaniasis was developed. The presence of cutaneous leishmaniasis was confirmed. Pentamidine was radioiodinated with (131)I. The radiolabeled...See full text at original site
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引用元：
https://doi.org/10.3109/1061186X.2013.878943

データ提供：米国国立医学図書館（NLM）

Radioiodinated Pentamidine for Leishmaniasis Imaging: A Limited Diagnostic Tool

In the field of [infectious diseases], [Leishmaniasis] poses a significant health challenge, particularly in tropical and subtropical regions. This study investigates the potential of [(131)I-Pentamidine] scintigraphy for detecting [Leishmania tropica infection] in an experimental model of [cutaneous leishmaniasis]. The authors evaluated the ability of [(131)I-Pentamidine] to accumulate at sites of infection, providing insights into its diagnostic potential.

Limited Sensitivity of (131)I-Pentamidine Scintigraphy for Leishmaniasis Detection

The study's findings, much like a desert mirage shimmering in the distance, reveal the limited sensitivity of [(131)I-Pentamidine] scintigraphy for detecting [Leishmania tropica infection]. While some accumulation of [(131)I-Pentamidine] was observed at sites of infection, the [target to non-target (T/NT) ratio] decreased with time, suggesting a lack of reliable diagnostic accuracy. These results indicate that [(131)I-Pentamidine] scintigraphy may not be a suitable tool for routine diagnosis of Leishmaniasis.

The Search for Effective Diagnostic Tools for Leishmaniasis: Exploring Alternatives

This study, much like a desert traveler facing a challenging landscape, highlights the ongoing search for effective diagnostic tools for Leishmaniasis. The limited sensitivity of [(131)I-Pentamidine] scintigraphy underscores the need for further research and development of alternative diagnostic approaches to improve the early detection and management of this debilitating disease.

Dr. Camel's Conclusion

This study, much like a desert traveler facing a challenging landscape, highlights the ongoing search for effective diagnostic tools for Leishmaniasis. The limited sensitivity of [(131)I-Pentamidine] scintigraphy underscores the need for further research and development of alternative diagnostic approaches to improve the early detection and management of this debilitating disease.

Date :
  1. Date Completed 2014-12-23
  2. Date Revised 2016-11-25
Further Info :

Pubmed ID

24405123

DOI: Digital Object Identifier

10.3109/1061186X.2013.878943

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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