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Inhibitors of catechol-O-methyltransferase in the treatment of neurological disorders.

Author: ApoorvaN, JatanaNidhi, LathaNarayanan, MalikSonika, SharmaAditya

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This article reviews the current knowledge on Catechol-O-methyltransferase (COMT) and the role of COMT inhibitors in the treatment of neurological disorders. It discusses the history of COMT inhibitor development, including the challenges associated with first-generation inhibitors, and highlights the potential of second-generation inhibitors like tolcapone and entacapone. However, these inhibitors are associated with various dopaminergic and gastrointestinal side-effects. The article also discusses the need for further research to develop new generation COMT inhibitors with a good and safe therapeutic profile.
Paper Details　
Original Abstract of the Article :
Catechol-O-methyltransferase (COMT) is the enzyme which catalyzes the transfer of a methyl group from S-adenosylmethionine to catechols and catecholamines, like the neurotransmitters dopamine, epinephrine and norepinephrine. COMT has implications in many neurological and psychiatric disorders like s...See full text at original site
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引用元：
https://doi.org/10.2174/1871524913666140109113341

データ提供：米国国立医学図書館（NLM）

A New Approach to Neurological Disorders: Targeting the COMT Enzyme

Catechol-O-methyltransferase (COMT), an enzyme that plays a role in the brain's chemistry, is a key player in many neurological disorders, like Parkinson's disease and schizophrenia. Think of COMT as a desert oasis, vital for maintaining the balance of chemicals in the brain. This research delves into the development of COMT inhibitors, like a thirsty traveler searching for a reliable source of water, aiming to restore the balance in the brain's chemical desert.

Understanding the Potential of COMT Inhibitors

The researchers are exploring the potential of COMT inhibitors as a treatment for a variety of neurological disorders. They are studying how these inhibitors can help to restore balance to the brain's chemical desert, much like adding a new well to an oasis. This research is like finding a new path through a desert of neurological conditions, offering hope for those who are struggling.

Navigating the Desert of Neurological Disorders

This research is a step forward in our understanding of neurological disorders. The exploration of COMT inhibitors is like navigating a vast desert, searching for new oases of hope and effective treatments. It's crucial to remember that neurological conditions are complex, and this research is part of a continuous journey to find better ways to treat and manage these conditions.

Dr.Camel's Conclusion

This research shines a light on the complex chemical landscape of the brain. The exploration of COMT inhibitors is like finding a new oasis in the desert of neurological disorders, offering hope for those who are struggling. It's a reminder that even in the face of complex challenges, relentless research and innovation can lead to new solutions.

Date :
  1. Date Completed 2014-12-22
  2. Date Revised 2019-11-12
Further Info :

Pubmed ID

24450388

DOI: Digital Object Identifier

10.2174/1871524913666140109113341

SNS
PICO Info
in preparation
Languages

English

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