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Absolute bioavailability of hydromorphone after peroral and rectal administration in humans: saliva/plasma ratio and clinical effects.
Author: CoyleD E, DensonD D, GreggR V, ParabP V, RitschelW A
Original Abstract of the Article :
The absolute bioavailability of hydromorphone was investigated in eight healthy male subjects by a cross-over design (with washout period of two weeks) after intravenous (2 mg), peroral (4 mg) and rectal (3 mg) administration of hydromorphone. The use of saliva hydromorphone concentrations as a noni...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://doi.org/10.1002/j.1552-4604.1987.tb03082.x
データ提供：米国国立医学図書館（NLM）
Exploring the Bioavailability of Hydromorphone
Hydromorphone is a powerful opioid medication used to manage pain. This study investigates the bioavailability of hydromorphone after administration through different routes, including intravenous, peroral, and rectal. The authors use a crossover design to compare the pharmacokinetic properties of hydromorphone after each route of administration. Their findings provide important insights into the optimal administration route for hydromorphone, maximizing therapeutic efficacy and minimizing side effects.
Bioavailability of Hydromorphone After Different Routes of Administration
This study reveals significant differences in hydromorphone bioavailability after intravenous, peroral, and rectal administration. The study found that peroral administration resulted in a higher bioavailability compared to rectal administration. These findings highlight the importance of carefully considering the administration route for hydromorphone, as it can significantly impact the drug's effectiveness and the risk of side effects.
Using Hydromorphone Safely and Effectively
As a doctor, I understand the importance of using opioids safely and effectively. This study provides valuable insights into the pharmacokinetic properties of hydromorphone and the potential impact of different administration routes. It's crucial to work closely with a doctor and to carefully follow recommended dosages and administration guidelines to minimize the risk of side effects and maximize the therapeutic benefits of hydromorphone.
Dr.Camel's Conclusion
Hydromorphone is a powerful tool for managing pain, but like a desert oasis, it must be approached with care. This study is like a guide through the desert, showing us the most effective routes to reach our destination while avoiding the dangers of the surrounding landscape. By understanding the bioavailability of hydromorphone, we can use it safely and effectively to manage pain and improve the lives of our patients.
Date :
- Date Completed 1988-01-11
- Date Revised 2019-08-24
Further Info :
Related Literature
English
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