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Addition of the calcium antagonist PN 200-110 to pindolol markedly augments the antihypertensive effect in essential hypertension.

Author: AndrénL, AurellM, DahlöfB, EggertsenR, HanssonL, JernS, SievertA, SvenssonA

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

PN 200-110, a new dihydropyridine calcium antagonist, was found to significantly reduce blood pressure in 20 patients with essential hypertension when added to pindolol. There was no significant increase in heart rate or changes in ionized calcium. Side effects were few and mild.
Paper Details　
Original Abstract of the Article :
Several large-scale studies have recently drawn attention to the fact that arterial hypertension frequently is inadequately controlled and that therapeutic alternatives other than the commonly employed stepped-care treatment may be needed in order to obtain normotension. For this reason PN 200-110, ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2455104

データ提供：米国国立医学図書館（NLM）

PN 200-110: A Powerful Adjunct to Pindolol for Hypertension

Hypertension is a prevalent health issue, much like a constant desert wind that can wear down a traveler's resilience. This study investigated the effects of adding PN 200-110, a calcium antagonist, to pindolol, a beta-blocker, in patients with essential hypertension. The researchers aimed to assess the combined antihypertensive effect of these medications.

A Synergistic Approach to Blood Pressure Control

The study found that adding PN 200-110 to pindolol significantly augmented the antihypertensive effect, leading to a greater reduction in blood pressure. These findings suggest that combining these medications could be an effective strategy for achieving better blood pressure control in patients with essential hypertension.

Optimizing Blood Pressure Management

Hypertension, like a desert mirage that can mislead travelers, requires a multifaceted approach to management. The study highlights the potential benefits of combining different classes of medications to optimize blood pressure control. The findings suggest that adding PN 200-110 to pindolol could offer a more effective and personalized approach to hypertension management.

Dr.Camel's Conclusion

This research explores the synergistic effects of combining PN 200-110 with pindolol for treating essential hypertension. The study suggests that this combination therapy can lead to greater reductions in blood pressure, offering a promising approach to managing this common health concern.

Date :
  1. Date Completed 1988-08-04
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2455104

DOI: Digital Object Identifier

2455104

Related Literature

Article Analysis
・Side Effects of pindolol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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