Paper Details

  1. Home
  2. Paper Details

Involvement of hypothalamic neuropeptide Y in pentazocine induced suppression of food intake in rats.

Author: HadolePravin N, KokareDadasaheb M, KotagaleNandkishor R, TaksandeBrijesh G, UpadhyaManoj

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Pentazocine, a sigma1 receptor agonist, reduced food intake in satiated rats, while neuropeptide Y (NPY) increased food intake. Pretreatment with NPY normalized the inhibitory effect of pentazocine on food intake, while pretreatment with pentazocine antagonized the orexigenic effect of NPY. Pentazocine decreased NPY immunoreactivity in the hypothalamus, suggesting that reduced NPY immunoreactivity may contribute to the anorectic effect of pentazocine.
Paper Details　
Original Abstract of the Article :
The potent orexigenic peptide neuropeptide Y (NPY) has been considered as a possible endogenous ligand for a subpopulation of sigma receptors (SigR). However, their mutual interaction with reference to feeding behavior remains poorly understood. In the present study, we explored the possible interac...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.npep.2014.02.003

データ提供：米国国立医学図書館（NLM）

Involvement of hypothalamic neuropeptide Y in pentazocine induced suppression of food intake in rats

This research delves into the intricate world of [neurobiology and feeding behavior], investigating the complex interplay between the neuropeptide Y (NPY) system and the sigma1 receptor (Sig1R) agonist, pentazocine, in regulating food intake. The study explored the interaction between these systems in the hypothalamus, a brain region crucial for regulating hunger and satiety. The researchers found that pentazocine suppressed food intake in rats, while NPY stimulated it. Notably, they discovered that NPY could counteract the anorectic effect of pentazocine, suggesting a potential interplay between these systems in regulating appetite.

NPY: A Key Player in the Hunger-Satiety Dance

The research sheds light on the crucial role of NPY in regulating food intake, demonstrating its ability to counteract the appetite-suppressing effects of pentazocine. This finding suggests that NPY might be a potential target for therapeutic interventions aimed at modulating appetite and managing conditions associated with altered feeding behavior. It's like a dance between two desert travelers: one seeking sustenance, the other seeking to quench thirst, each influencing the other's journey.

Understanding Appetite and Its Regulation

The study's findings contribute to our understanding of the complex mechanisms regulating appetite and food intake. It highlights the importance of the NPY system in this process, revealing its potential as a target for therapeutic intervention. This knowledge could be instrumental in developing strategies for addressing various conditions, such as obesity, anorexia, and other disorders involving altered feeding patterns.

Dr.Camel's Conclusion

This research takes us on a fascinating journey through the desert of the brain, revealing the intricate dance between NPY and pentazocine in regulating appetite. The study underscores the complexity of feeding behavior and highlights the importance of further research into the NPY system as a potential target for treating disorders associated with altered appetite.
Date :
  1. Date Completed 2014-12-24
  2. Date Revised 2023-12-13
Further Info :

Pubmed ID

24656792

DOI: Digital Object Identifier

10.1016/j.npep.2014.02.003

Related Literature

Article Analysis
・Side Effects of pentazocine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.